A nutritional immunity blockade controls extracellular bacterial replication inLegionella pneumophilainfections
Ascención Torres-Escobar,
Ashley Wilkins,
María D Juárez-Rodríguez
et al.
Abstract:The accidental human pathogenLegionella pneumophila(Lp) is the etiological agent for a severe atypical pneumonia known as Legionnaires′ disease. In human infections and animal models of disease alveolar macrophages are the primary cellular niche that supports bacterial replication within a unique intracellular membrane–bound organelle. The Dot/Icm apparatus – a type IV secretion system that translocates ~300 bacterial proteins within the cytosol of the infected cell – is a central virulence factor required for… Show more
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