A nutrigenetic precision approach for the management of non-alcoholic fatty liver disease

Perez-Diaz-del-Campo, Nuria; Dileo, Eleonora; Castelnuovo, Gabriele; Nicolosi, Aurora; Guariglia, Marta; Caviglia, Gian Paolo; Rosso, Chiara; Armandi, Angelo; Bugianesi, Elisabetta

doi:10.1016/j.clnu.2023.09.022

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…genes are examples of the most studied genes in this context. 92 The most important is to recognize the functional role of any detected genetic variant and the mechanistic pathogenic pathway. The PNPLA3 p.I148M variant is a good example, being the most This article is protected by copyright.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Tailored Model of Care for Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

El-Kassas,

Awad,

Elbadry

et al. 2024

Semin Liver Dis

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Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is increasing globally, creating a growing public health concern. However, this disease is often not diagnosed, and accurate data on its epidemiology are limited in many geographical regions, making it challenging to provide proper care and implement effective national plans. To combat the increasing disease burden, screening and diagnosis must reach a significant number of high-risk subjects. Addressing MASLD as a healthcare challenge requires a multidisciplinary approach involving prevention, diagnosis, treatment, and care, with collaboration between multiple stakeholders in the healthcare system. This approach must be guided by national and global strategies, to be combined with efficient models of care developed through a bottom-up process. This review article highlights the pillars of the MASLD model of care, including screening, risk stratification, and establishing a clinical care pathway for management, in addition to discussing the impact of nomenclature change on the proposed model of care.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Tailored Model of Care for Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

El-Kassas,

Awad,

Elbadry

et al. 2024

Semin Liver Dis

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“…The management of MASLD primarily involves caloric restriction through lifestyle modifications and increased physical activity [76]. The MD has been shown to be the most effective approach, but other dietary strategies, such as low-fat, low-carbohydrate, and ketogenic diets, have also shown positive effects on metabolic disease outcomes [12,19].…”

Section: Implementation Of a Plant-based Diet In Masld Managementmentioning

confidence: 99%

A Healthful Plant-Based Diet as an Alternative Dietary Approach in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease

Castelnuovo,

Perez-Diaz-del-Campo,

Rosso

et al. 2024

Nutrients

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Plant-based diets (PBDs) are gaining attention as a sustainable and health-conscious alternative for managing various chronic conditions, including metabolic dysfunction-associated steatotic liver disease (MASLD). In the absence of pharmacological treatments, exploring the potential of lifestyle modifications to improve biochemical and pathological outcomes becomes crucial. The adoption of PBDs has demonstrated beneficial effects such as weight control, increased metabolic health and improved coexisting diseases. Nonetheless, challenges persist, including adherence difficulties, ensuring nutritional adequacy, and addressing potential deficiencies. The aim of this review is to provide a comprehensive overview of the impact of PBDs on MASLD, emphasizing the need for tailored dietary interventions with professional support to optimize their effectiveness in preventing and treating metabolic diseases.

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The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene–diet study from the UK Biobank

Liu,

Huang,

Ruan

et al. 2024

The American Journal of Clinical Nutrition

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A nutrigenetic precision approach for the management of non-alcoholic fatty liver disease

Cited by 5 publications

References 24 publications

Tailored Model of Care for Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

Tailored Model of Care for Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease

A Healthful Plant-Based Diet as an Alternative Dietary Approach in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease

The sulfur microbial diet and risk of nonalcoholic fatty liver disease: a prospective gene–diet study from the UK Biobank

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