A nutrient drink test to assess maximum tolerated volume and postprandial symptoms: effects of gender, body mass index and age in health

Chial, Heather J.; Camilleri, Christopher E; Delgado-Aros, Sílvia; Burton, Duane D.; Thomforde, George M.; Ferber, Irene; Camilleri, Michael

doi:10.1046/j.1365-2982.2002.00326.x

Cited by 115 publications

(118 citation statements)

References 3 publications

(10 reference statements)

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“…A standardized nutrient drink test to measure satiation and postprandial symptoms was used (13). The method has been used extensively in previous studies, and a liquid nutrient drink, Ensure (1 Kcal/ml, 11% fat, 73% carbohydrate, and 16% protein), was used to identify maximum tolerated volume at full satiation, as well as postprandial fullness, nausea, bloating, and pain 30 min after the meal.…”

Section: Satiation By the Nutrient Drink Testmentioning

confidence: 99%

“…The following measurements were obtained: 1) the sensory thresholds for first sensation, gas, urgency, and pain during ascending method of limits, 2) the three individual sensation scores (gas, urgency, and pain) in response to the three random phasic distensions (13,25,32, and 36 mmHg above BOP), and 3) rectal compliance.…”

Section: Rectal Compliance and Sensation By Barostatmentioning

confidence: 99%

See 1 more Smart Citation

Candidate genes and sensory functions in health and irritable bowel syndrome

Camilleri

Busciglio

Carlson

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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Zinsmeister AR. Candidate genes and sensory functions in health and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 295: 219 -225, 2008. First published May 29, 2008 doi:10.1152/ajpgi.90202.2008.-Adrenergic and serotonergic (ADR-SER) mechanisms alter gut (GI) function; these effects are mediated through G protein transduction. Candidate genetic variations in ADR-SER were significantly associated with somatic scores in irritable bowel syndrome (IBS) and gastric emptying but not small bowel or colonic transit. Our aim was to assess whether candidate ADR-SER genes are associated with motor and sensory GI functions in IBS and subgroups on the basis of bowel dysfunction. In 122 patients with IBS and 39 healthy controls, we assessed gastrointestinal somatic symptoms and affect by validated questionnaires. We measured: gastric volume (GV), maximum tolerated volume, rectal compliance, sensation thresholds and ratings, and genetic variations including ␣2A (C-1291G), ␣2C (Del 332-325), GN␤3 (C825T), and 5-HTTLPR. Demographics and genotype distributions were similar in the patients with IBS subgrouped on bowel function. There were significant associations between 5-HTTLPR SS genotype and absence of IBS symptoms and between 5-HTTLPR LS/SS genotype and increased rectal compliance and increased pain ratings, particularly at 12 and 24 mmHg distensions. GN␤3 was associated only with fasting GV; we did not detect associations between ␣2A genotype and the gastrointestinal sensory or motor functions tested. We concluded that 5-HTTLPR LS/SS genotype is associated with both increased pain sensation and increased rectal compliance though the latter effect is unlikely to contribute to increased pain sensation ratings with LS/SS genotype. The data suggest the hypotheses that the endophenotype of visceral hypersensitivity in IBS may be partly related to genetic factors, and the association of GN␤3 with fasting GV may explain, in part, the reported association of GN␤3 with dyspepsia. adrenergic; serotonergic; GN␤3; SLC6A4; G protein; receptor ADRENERGIC MECHANISMS alter gastrointestinal reflexes involved in intestinal propulsion, coordinated motor activity in the small bowel and colon, and gastrointestinal tone and fluid secretion (12,46). Norepinephrine is also involved in control of pain including supraspinal inhibition of pain, e.g., due to a change in the behavioral state (37) including stress, which contributes to gut motility disorders (10).Among ␣2 receptors, the ␣2A subtype appears to be critically important for control of motor functions, such as gastrointestinal transit in mice (40) and colonic circular smooth muscle in canine colon (47). The ␣2 receptor agonist, clonidine, inhibits gastric and colonic tone, phasic contractility, and sensation in the rectum and colon in response to balloon distension in healthy humans (4, 43).Serotonergic (5-HT) mechanisms also alter gut absorptive, motor, and sensory functions via actions in the gut, spinal cord, and brain stem (27). Ligand-receptor interaction results in c...

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Section: Satiation By the Nutrient Drink Testmentioning

confidence: 99%

Section: Rectal Compliance and Sensation By Barostatmentioning

confidence: 99%

Candidate genes and sensory functions in health and irritable bowel syndrome

Camilleri

Busciglio

Carlson

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…On days 8-10, gastrointestinal and colonic transit were measured by scintigraphy (4,5). Evaluation of the maximum tolerated volume and postprandial symptoms using the nutrient drink test (6) and gastric emptying of the nutrient liquid by scintigraphy was completed on day 10. Change in gastric volume after a standardized meal was assessed by single-photon emission-computed tomography (SPECT) on day 11 (16).…”

Section: Experimental Design and Participantsmentioning

confidence: 99%

“…The aim of our study was to compare the effects of buspirone, paroxetine, and venlafaxine-XR vs. placebo on 1) gastrointestinal and colonic transit, 2) the maximum tolerated volume of a nutrient drink, 3) postprandial symptoms, and 4) changes in gastric volume after a standardized meal in healthy adults. Validated noninvasive techniques have been developed in our laboratory to measure these functions (4)(5)(6)16).…”

mentioning

confidence: 99%

Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health

Chial

Camilleri

Burton

et al. 2003

American Journal of Physiology-Gastrointestinal and Liver Physi

110

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This study evaluated the effects of serotonergic psychoactive agents on gastrointestinal functions in healthy human subjects. Participants received one of four regimens in a randomized, double-blind manner: buspirone, a 5-HT1Areceptor agonist (10 mg twice daily); paroxetine, a selective serotonin reuptake inhibitor (20 mg daily); venlafaxine-XR, a selective serotonin and norepinephrine reuptake inhibitor (75 mg daily); or placebo for 11 days. Physiological testing performed on days 8–11included scintigraphic assessment of gastrointestinal and colonic transit, the nutrient drink test, and assessment of the postprandial change in gastric volume. Fifty-one healthy adults (40 females, 11 males) participated in this study. No effects on gastric emptying or colonic transit were identified with any agent. Small bowel transit of a solid meal was accelerated by paroxetine. Buspirone decreased postprandial aggregate symptom and nausea scores. Venlafaxine-XR increased the postprandial change in gastric volume. Buspirone, paroxetine, and venlafaxine-XR affect upper gastrointestinal functions in healthy humans. These data support the need for clinical and physiological studies of these agents in functional gastrointestinal disorders.

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“…The the four 100-mm VAS scales for each symptoms. 8,9 total ingested volume that the test had to be stopped because the FD patients or healthy controls could not tolerate more volume.…”

Section: Methodsmentioning

confidence: 99%

Maximum Tolerated Volume and Plasma Acylated Ghrelin Levels after Drink Tests in Patients with Functional Dyspepsia

Cahyono

Ratnasari

Bayupurnama

et al. 2015

InaJGHE

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Background: Impaired gastric accommodation and visceral hypersensitivity are major pathophysiological mechanism in functional dyspepsia (FD). Ghrelin, as gut hormone, may play a pathophysiological role in functional dyspepsia. Nutrient drink test was developed to assess impaired gastric accommodation in FD patients. The aims of this study are to compare maximum tolerated volume, postprandial symptoms and acylated ghrelin levels between dyspepsia functional patients and healthy subjects as controls.Method: A cross sectional study was conducted from July 2014 to November 2014, at Sardjito General Hospital, Yogyakarta. Twenties functional dyspepsia patients and 20 healthy subjects ingested nutrient drink tests (Ultra Milk contain 0.6 kcal/mL). The maximum tolerated volume was recorded. After ingested maximal tolerated volume, nausea, bloating and pain were rated using visual analogue scales (VAS) with 100 mm lines. The levels of acylated ghrelin was recorded before and 30 minutes after maximal drinking.Results: The demographic characteristics (age, sex, and body mass index) between dyspepsia patients and healthy subjects were compared. Patients with functional dyspepsia ingested 600 (350–1000) mL and healthy subjects ingested 1375 (1000–1900) mL (p 0.001). The total symptom scores were higher in dyspepsia patients compared healthy subjects; 215 (110–350) vs. 75 (50–120) (p 0,001). The fasting plasma levels of acylated ghrelin (20.65 : 2 – 31.37 pg/mL) in FD patients were significantly lower than healthy subjects (30.61 : 2 – 251.19 pg/mL) ( p = 0.012). Conclusion: Patients with functional dyspepsia ingested significantly lower volume and significantly have higher score symptoms than healthy subjects. The fasting plasma levels of acylated ghrelin in functional dyspepsia patients were significantly lower than healthy subjects.

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A nutrient drink test to assess maximum tolerated volume and postprandial symptoms: effects of gender, body mass index and age in health

Cited by 115 publications

References 3 publications

Candidate genes and sensory functions in health and irritable bowel syndrome

Candidate genes and sensory functions in health and irritable bowel syndrome

Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health

Maximum Tolerated Volume and Plasma Acylated Ghrelin Levels after Drink Tests in Patients with Functional Dyspepsia

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