A nutraceutical product based on Jerte Valley cherries improves sleep and augments the antioxidant status in humans

Garrido, María; Espino, Javier; González‐Gómez, David; Lozano, M.; Juánez, Javier Cubero; Toribio-Delgado, Antonio F.; Maynar-Mariño, Juan I.; Terrón, M. Pilar; Muñoz, Juan L.; Pariente, José A.; Barriga, C.; Paredes, Sergio D.; Rodríguez, Ana B.

doi:10.1016/j.eclnm.2009.09.003

Cited by 37 publications

(34 citation statements)

References 11 publications

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“…It is well-known that diet with high levels of antioxidants may enhance life quality (Reiter et al 2005;Rizwan et al 2011) In previous reports, we showed that tryptophan administration was able to reverse the age-related changes in the circulating levels of melatonin and serotonin in both mammals and ringdoves (Aparicio et al 2007;Paredes et al 2007;Sánchez et al 2008a, b). Also, we reported that diets enriched with tryptophan itself or with foodstuffs containing high levels of this amino acid were able to both consolidate sleep in newborns (Cubero et al 2005 and improve sleep and antioxidant capacity levels in young, middle-aged, and elderly individuals (Garrido et al 2009(Garrido et al , 2010. Thus, the aim of the present work was to evaluate the effect of tryptophan-enriched cereals on sleep, serotonin, melatonin, total antioxidant capacity levels, and mood in elderly humans.…”

Section: Introductionmentioning

confidence: 90%

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Bravo

Matito²,

Juánez

et al. 2012

AGE

138

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Melatonin and serotonin rhythms, which exhibit a close association with the endogenous circadian component of sleep, are attenuated with increasing age. This decrease seems to be linked to sleep alterations in the elderly. Chrononutrition is a field of chronobiology that establishes the principle of consuming foodstuffs at times of the day when they are more useful for health, improving, therefore, biorhythms and physical performance. Our aim was to analyze whether the consumption of cereals enriched with tryptophan, the precursor of both serotonin and melatonin, may help in the reconsolidation of the sleep/wake cycle and counteract depression and anxiety in 35 middle-aged/elderly (aged 55-75 year) volunteers in a simple blind assay. Data were collected for 3 weeks according to the following schedule: The control week participants consumed standard cereals (22.5 mg tryptophan in 30 g cereals per dose) at breakfast and dinner; for the treatment week, cereals enriched with a higher dose of tryptophan (60 mg tryptophan in 30 g cereals per dose) were eaten at both breakfast and dinner; the posttreatment week volunteers consumed their usual diet. Each participant wore a wrist actimeter that logged activity during the whole experiment. Urine was collected to analyze melatonin and serotonin urinary metabolites and to measure total antioxidant capacity. The consumption of cereals containing the higher dose in tryptophan increased sleep efficiency, actual sleep time, immobile time, and decreased total nocturnal activity, sleep fragmentation index, and sleep latency. Urinary 6-sulfatoxymelatonin, 5-hydroxyindoleacetic acid levels, and urinary total antioxidant capacity also increased respectively after tryptophan-enriched cereal ingestion as well as improving anxiety and depression symptoms. Cereals enriched

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Section: Introductionmentioning

confidence: 90%

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Bravo

Matito²,

Juánez

et al. 2012

AGE

138

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“…ES2342141B1) diluted in 250 ml of water. The product mix was freshly prepared every day and consisted of 18.85 g freeze‐dried cherries (equivalent to 141 g pitted fresh cherries) in equal parts of four Jerte Valley cherry cultivars (Bourlat, Navalinda, Pico Negro, and Pico Colorado), plus 7.5 g maltodextrin, and 1.5 g ascorbic acid (Garrido et al., 2009). The treatment with the nutraceutical product mix was administered for 10 consecutive days.…”

Section: Methodsmentioning

confidence: 99%

Diets enriched with a Jerte Valley cherry‐based nutraceutical product reinforce nocturnal behaviour in young and old animals of nocturnal (Rattus norvegicus) and diurnal (Streptopelia risoria) chronotypes

Delgado

Terrón

Garrido

et al. 2011

Animal Physiology Nutrition

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The decline in melatonin secretion with age seems to be one of the major reasons for increased sleep disruption in older animals. Previously, we showed that the administration with melatonin or its precursor, tryptophan, improved activity/rest rhythms in aged individuals. Here, it was evaluated the effect of a 10-day consumption of a Jerte Valley cherry-based nutraceutical product (patent no. ES2342141B1), which contains high levels of tryptophan, serotonin and melatonin, on the activity/rest rhythms of young and old rats (Rattus norvegicus) and ringdoves (Streptopelia risoria) as representatives of animals with nocturnal and diurnal habits, respectively, and its possible relationship with the serum levels of melatonin and glucose. Total diurnal and nocturnal activity pulses were logged at control, during, and up to 3 days after the treatment. Melatonin and glucose were measured with ELISA and testing kits respectively. In both young and old rats, the intake of the cherry nutraceutical decreased diurnal activity, whereas nocturnal activity increased. The opposite effect was observed for ringdoves. The treatment increased the circulating levels of melatonin in both species and restored the amplitude of the activity rhythm in the old animals to that of the non-treated young groups. The consumption of a Jerte Valley cherry-based nutraceutical product may help to counteract the impaired activity/rest rhythm found in aged animals.

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“…It is known that increased levels of circulating melatonin -produced directly by exogenous administration or indirectly by introducing it into the diet with vegetables rich in this compound -enhance the individual's antioxidant status. 15,52 As it was discovered in plants, there has been an ever-growing number of studies reporting the detection of melatonin in a variety of fruits, 29 including both tart and sweet cherry. 53,54 Cherry fruit also has a significant amount of important bioactive components such as anthocyanins, quercitin or carotenoids.…”

Section: Tryptophan and Melatonin Against Oxidative Stress In Agingmentioning

confidence: 99%

Tryptophan and Melatonin-Enriched Foodstuffs to Improve Antioxidant Status in Aging

Garrido

Rodríguez

Terrón

2014

Aging

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A nutraceutical product based on Jerte Valley cherries improves sleep and augments the antioxidant status in humans

Cited by 37 publications

References 11 publications

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans

Diets enriched with a Jerte Valley cherry‐based nutraceutical product reinforce nocturnal behaviour in young and old animals of nocturnal (Rattus norvegicus) and diurnal (Streptopelia risoria) chronotypes

Tryptophan and Melatonin-Enriched Foodstuffs to Improve Antioxidant Status in Aging

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