A nutraceutical a day may keep the doctor away

Brower, Vicki

doi:10.1038/sj.embor.7400498

Cited by 37 publications

(15 citation statements)

References 5 publications

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“…With the availability of a larger selection of synthetic drugs, people are more aware of the side effects of taking drugs on a regular basis. Nutraceuticals or phytoceuticals are a class of compounds that are derived from plants with fewer or no side effects compared to synthetic drugs [ 157 ] but with similar and sometimes even better beneficial biological effects [ 158 ]. Hyperforin obtained from the herb Hypericum perforatum has been reported to inhibit COX-1 3–18-fold higher when compared to aspirin [ 158 ].…”

Section: Possible Alternatives To Nsaids For Reduced Cardiovasculmentioning

confidence: 99%

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Ghosh

Alajbegovic

Gomes

2015

Oxidative Medicine and Cellular Longevity

139

106

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide. NSAIDs are used for a variety of conditions including pain, rheumatoid arthritis, and musculoskeletal disorders. The beneficial effects of NSAIDs in reducing or relieving pain are well established, and other benefits such as reducing inflammation and anticancer effects are also documented. The undesirable side effects of NSAIDs include ulcers, internal bleeding, kidney failure, and increased risk of heart attack and stroke. Some of these side effects may be due to the oxidative stress induced by NSAIDs in different tissues. NSAIDs have been shown to induce reactive oxygen species (ROS) in different cell types including cardiac and cardiovascular related cells. Increases in ROS result in increased levels of oxidized proteins which alters key intracellular signaling pathways. One of these key pathways is apoptosis which causes cell death when significantly activated. This review discusses the relationship between NSAIDs and cardiovascular diseases (CVD) and the role of NSAID-induced ROS in CVD.

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Section: Possible Alternatives To Nsaids For Reduced Cardiovasculmentioning

confidence: 99%

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Ghosh

Alajbegovic

Gomes

2015

Oxidative Medicine and Cellular Longevity

139

106

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“…Notably, an interesting study by Smith et al describes the ability of microbial metabolites short-chain fatty acids, to directly enhance colonic T reg frequency via GPCR43 expressed by the immune cells (70). Overall, the idea of nutraceuticals (products that have both nutritional and pharmaceutical qualities), a term coined by Stephen DeFelice in 1989 (71), is becoming ever more interesting as we acquire information on how to direct immune response toward tolerance or inflammation, as appropriate. It’s not surprising that the major apparatus involved in food derived immunomodulation is the one that is the most exposed to food derived products.…”

Section: Evolution Of the Digestive Systemmentioning

confidence: 99%

Messages from the Inside. The Dynamic Environment that Favors Intestinal Homeostasis

Eri

Chieppa

2013

Front. Immunol.

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An organism is defined as “an individual living thing capable of responding to stimuli, growing, reproducing, and maintaining homeostasis.” Early during evolution multicellular organisms explored the advantages of a symbiotic life. Mammals harbor a complex aggregate of microorganisms (called microbiota) that includes bacteria, fungi, and archaea. Some of these bacteria have already defined beneficial roles for the human host that include the ability to break down nutrients that could not otherwise be digested, preventing the growth of harmful species, as well as the ability to produce vitamins or hormones. It is intuitive that along the evolutionary path several mechanisms favored bacteria that provided advantages to the host which, in return, avoided launching an aggressive immunological response against them. The intestinal immunological response does not ignore the lumenal content, on the contrary, immune surveillance is favored by continuous antigen sampling. Some intestinal epithelial cells (ECs) are crucial during the sampling process, others actively participate in the defense mechanism. In essence the epithelium acts as a traffic light, communicating to the inside world whether conditions are safe or dangerous, and thus influencing immunological response. In this review we will discuss the dynamic factors that act on the intestinal ECs and how they directly or indirectly influence immune cells during states of health and disease.

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“…Commonly used nutraceuticals in male infertility are: Treatment with nutraceuticals is widespread for a variety of conditions like atherosclerosis. The efficacy of nutraceuticals in the treatment of these conditions has not been proved 11 . Folic acid seems to have an apparent benefit in reducing aneuploidy in spermatozoa 5 .…”

Section: Nutraceuticals In Male Infertilitymentioning

confidence: 99%

Nutraceuticals in Sperm Abnormalities

2013

CHCMJ

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A nutraceutical a day may keep the doctor away

Cited by 37 publications

References 5 publications

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Messages from the Inside. The Dynamic Environment that Favors Intestinal Homeostasis

Nutraceuticals in Sperm Abnormalities

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