A nursing metaparadigm perspective of diabetic foot ulcer care

Subrata, Sumarno Adi; Phuphaibul, Rutja

doi:10.12968/bjon.2019.28.6.s38

Cited by 9 publications

(4 citation statements)

References 110 publications

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“…DFU is one of the most common complications of diabetes, causing not only burdens for patients but also posing challenges for overall health, nursing practices, and the social environment. 32 Patients with diabetes often experience weakened immune systems, and when coupled with the vulnerability of the feet as one of the body's vital organs, infections can exacerbate inflammation and ultimately play a role in the onset of DFU. 33 This study, from an immunological perspective, identified GSTM5 as a potential key target for DFU using machine learning and Based on the conclusions of this study, GSTM5 is significantly underexpressed in DFU tissues, suggesting that it may be a potential protective factor in DFU patients.…”

Section: Discussionmentioning

confidence: 99%

Identifying and Validating GSTM5 as an Immunogenic Gene in Diabetic Foot Ulcer Using Bioinformatics and Machine Learning

Shi,

Yuan,

Liu

et al. 2023

JIR

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Background: A diabetic foot ulcer (DFU) is a serious, long-term condition associated with a significant risk of disability and mortality. However, research on its biomarkers is still limited. This study utilizes bioinformatics and machine learning methods to identify immune-related biomarkers for DFU and validates them through external datasets and animal experiments. Methods: This study used bioinformatics and machine learning to analyze microarray data from the Gene Expression Omnibus (GEO) database to identify key genes associated with DFU. Animal experiments were conducted to validate these findings. This research employs the datasets GSE68183 and GSE80178 retrieved from the GEO database as the training dataset for building a gene machine learning model, and after conducting differential analysis on the data, this study used package glmnet and package e1071 to construct LASSO and SVM-RFE machine learning models, respectively. Subsequently, we validated the model using the training set and validation set (GSE134431). We conducted enrichment analysis, including GSEA and GSVA, on the model genes. We also performed immune functional analysis and immune-related analysis on the model genes. Finally, we conducted immunohistochemistry (IHC) validation on the model genes.Results: This study identifies GSTM5 as a potential immune-related key target in DFU using machine learning and bioinformatics methods. Subsequent validation through external datasets and IHC experiments also confirms GSTM5 as a critical biomarker for DFU. The gene may be associated with T cells regulatory (Tregs) and T cells follicular helper, and it influences the NF-κB, GnRH, and MAPK signaling pathway. Conclusion:This study identified and validated GSTM5 as a biomarker for DFU. This finding may potentially provide a target for immune therapy for DFU.

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Section: Discussionmentioning

confidence: 99%

Identifying and Validating GSTM5 as an Immunogenic Gene in Diabetic Foot Ulcer Using Bioinformatics and Machine Learning

Shi,

Yuan,

Liu

et al. 2023

JIR

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“…This is done with the participation of health system staff consisting of physicians and nurses. [ 19 ] Bentley and colleagues acknowledged that diabetic foot ulcers require specific management and. Diabetic foot ulcers require accurate and rapid assessment, diagnosis, treatment, and long-term follow-up in order to maintain the foot.…”

Section: Discussionmentioning

confidence: 99%

Experiences of nurses within a nurse-led multidisciplinary approach in providing care for patients with diabetic foot ulcer

Nayeri

Samadi

Mehrnoush

et al. 2020

J Family Med Prim Care

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Background and Aims: Diabetic foot ulcers require special attention due to their complex and chronic nature and special care and the Nurse-led approach has emerged in the current situation in response to the increasing need for health care as a way to treat chronic patients and provide them with ongoing care. Providing this specialized duty in nursing can be promoted and enhanced the professional independence of nurses and presents challenges. This study has been conducted to make an understanding of the nurses’ experiences about their participation in a nurse-led multidisciplinary team to providing care for patients with Diabetic Foot Ulcer. Methods: This was a qualitative, phenomenological research, carried out with the participation of 8 nurses of Shariaty Hospital of Tehran. Data collection was done through in-depth and semi structured interview. Dieklemann method was used for data analysis. Results: 2 themes and 4 categories emerged during data analysis: antecedents (background and nursing skills) and manifestation of multidisciplinary function (from despair to tranquility, professional worthiness, promotion of self-confidence, preference of multidisciplinary approach). Conclusion: The findings of this study, which were the lived experiences of the participants, indicated that most of them had experienced positive effect of nurse-led multidisciplinary team care, training and development, appropriate skill mix, quality and outcome of care. Therefore, despite working on a multidisciplinary team is complex and demanding, management attributions and communication strategies is well situated to meet the challenge.

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“…Embora esse estudo não tenha apresentado um grupo controle, os resultados demonstraram efeitos positivos quanto à redução da área da úlcera no grupo agudo (15) . paciente tomar decisões sobre seu próprio tratamento (16) .…”

Section: Em Estudo Descritivo Realizado Nounclassified

Cuidados De Enfermagem Na Prevenção E Tratamento De Úlceras Do Pé Diabético: Revisão De Escopo

Fontes

Oliveira

et al. 2023

Rev. Enferm. Atual In Derme

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Objetivo: mapear os cuidados de enfermagem para o tratamento e prevenção de úlceras do pé diabético. Métodos: revisão de escopo, produzido através das recomendações do Joanna Briggs Institute.Resultados: foram encontrados, inicialmente, 115 artigos e após a remoção de duplicatas, análise de títulos, resumos e leitura completa dos textos foram obtidos 13 resultados finais. A partir dessa busca, foi mencionado as seguintes abordagens terapêuticas: o desbridamento, a prevenção associada ao plano de cuidados de enfermagem (Como por exemplo, cuidados domiciliares com a alimentação e higiene), o uso de pele de peixe, metaparadigma para intervenção de enfermagem, a teleconsulta e o custo benefício das terapias utilizadas. Considerações finais: esta revisão apresentou diferentes manejos de promover a prevenção e aplicar intervenções sobre os pacientes com úlceras do pé diabético, inclusive ressalta acerca da necessidade de mais pesquisas relacionadas a tal temática.

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A nursing metaparadigm perspective of diabetic foot ulcer care

Cited by 9 publications

References 110 publications

Identifying and Validating GSTM5 as an Immunogenic Gene in Diabetic Foot Ulcer Using Bioinformatics and Machine Learning

Identifying and Validating GSTM5 as an Immunogenic Gene in Diabetic Foot Ulcer Using Bioinformatics and Machine Learning

Experiences of nurses within a nurse-led multidisciplinary approach in providing care for patients with diabetic foot ulcer

Cuidados De Enfermagem Na Prevenção E Tratamento De Úlceras Do Pé Diabético: Revisão De Escopo

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