A numerical study on pulsatile non-Newtonian hemodynamics in double-fusiform abdominal aortic aneurysms

Panchal, Pratik M.; Hathi, Dev S.; Shah, Niraj; Lakdawala, Absar

doi:10.1063/5.0084600

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…The Newtonian models had a constant viscosity of 0.0035 pa.s while the non-Newtonian models had effective viscosity calculated via the Carreau–Yasuda model 49 expressed as: where =0.0022 Pa.s, =0.022 Pa.s, =0.11 s, =0.644, n = 0.392 according to Gijsen et al 50 and is the local instantaneous shear rate magnitude.…”

Section: Methods: High Resolution Large Eddy Simulationmentioning

confidence: 99%

On non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation

Saqr

Zidane

2022

Sci Rep

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The study of turbulence in physiologic blood flow is important due to its strong relevance to endothelial mechanobiology and vascular disease. Recently, Saqr et al. (Sci Rep 10, 15,492, 2020) discovered non-Kolmogorov turbulence in physiologic blood flow in vivo, traced its origins to the Navier–Stokes equation and demonstrated some of its properties using chaos and hydrodynamic-stability theories. The present work extends these findings and investigates some inherent characteristics of non-Kolmogorov turbulence in monoharmonic and multiharmonic pulsatile flow under ideal physiologic conditions. The purpose of this work is to propose a conjecture for the origins for picoNewton forces that are known to regulate endothelial cells’ functions. The new conjecture relates these forces to physiologic momentum-viscous interactions in the near-wall region of the flow. Here, we used high-resolution large eddy simulation (HRLES) to study pulsatile incompressible flow in a straight pipe of $$L/D=20$$ L / D = 20 . The simulations presented Newtonian and Carreau–Yasuda fluid flows, at $$R{e}_{m}\approx 250$$ R e m ≈ 250 , each represented by one, two and three boundary harmonics. Comparison was established based on maintaining constant time-averaged mass flow rate in all simulations. First, we report the effect of primary harmonics on the global power budget using primitive variables in phase space. Second, we describe the non-Kolmogorov turbulence in frequency domain. Third, we investigate the near-wall coherent structures in time and space domains. Finally, we propose a new conjecture for the role of turbulence in endothelial cells’ mechanobiology. The proposed conjecture correlates near-wall turbulence to a force field of picoNewton scale, suggesting possible relevance to endothelial cells mechanobiology.

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Section: Methods: High Resolution Large Eddy Simulationmentioning

confidence: 99%

On non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation

Saqr

Zidane

2022

Sci Rep

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show abstract

“…The Newtonian models had a constant viscosity of 0.0035 pa.s while the non-Newtonian models had effective viscosity calculated via the Carreau-Yasuda model 49 expressed as: where μ ∞ =0.0022 Pa.s, μ 0 =0.022 Pa.s, λ =0.11 s, a =0.644, n=0.392 according to Gijsen et al 50 and is the local instantaneous shear rate magnitude.…”

Section: Methods: High Resolution Large Eddy Simulationmentioning

confidence: 99%

“…The Newtonian models had a constant viscosity of 0.0035 pa.s while the non-Newtonian models had effective viscosity calculated via the Carreau-Yasuda model 49 expressed as:…”

Section: Governing Equationsmentioning

confidence: 99%

On Non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation

Saqr

Zidane

2022

Preprint

View full text Add to dashboard Cite

The study of turbulence in physiologic blood flow is important due to its strong relevance to endothelial mechanobiology and vascular disease. Recently, Saqr et al (Sci. Rep. 10, 15492, 2020) discovered non-Kolmogorov turbulence in physiologic blood flow in vivo, traced its origins to the Navier-Stokes equation and demonstrated some of its properties using chaos and hydrodynamic-stability theories. The present work extends these findings and investigates some inherent characteristics of non-Kolmogorov turbulence in monoharmonic and multiharmonic pulsatile flow under ideal physiologic conditions. The purpose of this work is to propose a conjecture for the origins for picoNewton forces that are known to regulate endothelial cells' functions. The new conjecture relates these forces to physiologic momentum-viscous interactions in the near-wall region of the flow. Here, we used high-resolution large eddy simulation (HRLES) to study pulsatile incompressible flow in a straight pipe of L/D=20. The simulations presented Newtonian and Carreau-Yasuda fluid flows, at Reynolds number of 256 and 228, respectively, each represented by one, two and three boundary harmonics. Comparison was established based on maintaining constant time-averaged mass flow rate in all simulations. First, we report the effect of primary harmonics on the global power budget using primitive variables in phase space. Second, we describe the non-Kolmogorov turbulence in frequency domain. Third, we investigate the near-wall coherent structures in time, space and frequency domains. Finally, we propose a new conjecture for the role of turbulence in endothelial cells' mechanobiology. The proposed conjecture correlates near-wall turbulence to a force field of picoNewton scale, suggesting possible relevance to endothelial cells mechanobiology.

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Hemodynamics of different configurations of the left subclavian artery parallel stent graft for thoracic endovascular aortic repair

Che,

Zhao,

Zhang

et al. 2023

Computer Methods and Programs in Biomedicine

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A numerical study on pulsatile non-Newtonian hemodynamics in double-fusiform abdominal aortic aneurysms

Cited by 5 publications

References 35 publications

On non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation

On non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation

On Non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation

Hemodynamics of different configurations of the left subclavian artery parallel stent graft for thoracic endovascular aortic repair

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