A Numerical Study on Mechanical Performance and Hemolysis for Different Types of Centrifugal Blood Pumps

Chang, Minwook; Hur, Nahmkeon; Moshfeghi, Mohammad; Kang, Seongwon; Kim, Wonjung; Kang, Shin-Hyung

doi:10.1115/imece2015-53568

Cited by 4 publications

(6 citation statements)

References 21 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The area near the impeller inlet has the lowest pressure. Figure 7 shows the scalar shear stress distribution at ECMO condition, which is an important factor in analysis of hemolysis by Equations (8)(9)(10). The high scalar shear stresses area are located inside volute and outside of impeller walls.…”

Section: Resultsmentioning

confidence: 99%

“…So Lagrangian approaches can't accurately measure [7]. In this research a baseline model via designed by investigating the existing commercial blood pumps [8], by considering the results of CFD simulations, performance curves and bio-mechanical factor analyses such as hemolysis. Furthermore, the baseline model is modified according to its hemolysis performance in ECMO condition, and two more geometries are designed and simulated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of a Centrifugal Blood Pump for Ecmo and Vad Operations

Choi¹,

Hur²,

Moshfeghi³

et al. 2016

Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016)

Self Cite

View full text Add to dashboard Cite

Using cardiopulmonary circulatory assist devices has been increased in the recent years as more models are available in the market. These devices can be employed in the situation during which both cardiac and respiratory support to a patient's heart and lungs have to be provided, either during or after surgeries, for short time or even in the case of severe disease, for a period of weeks. Hence, it is critical to know the details of the phenomena happen inside a blood pump from both mechanical performances (such as pressure head and mechanical efficiency) and biomedical factors (such as hemolysis and thrombosis) and to design an optimum pump from both aspects. This paper investigates development of centrifugal blood pump impeller, specifically with focusing on the performances during ECMO condition. The baseline model is designed by investigating existing commercial pumps and considering results of recirculation, pressure heads and mechanical efficiencies together with their biomechanical performance via Modified Indices of Hemolysis (MIH). Afterword, two more modified models are designed and simulated. Overall, a comprehensive comparison between the results of all three case demonstrate that when impeller radius and prime volume is smaller, recirculation is reduced at impeller and MIH value becomes lower. Additionally, high scalar shear stress is observed near the volute and impeller walls and inside the top cavity gap.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a Centrifugal Blood Pump for Ecmo and Vad Operations

Choi¹,

Hur²,

Moshfeghi³

et al. 2016

Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016)

Self Cite

View full text Add to dashboard Cite

show abstract

“…29 MIH calculation is of great importance in the estimation of potential blood damage. 30 MIH was calculated using a Euler scalar transport approach using the equation 31 :…”

Section: Blood Damage Estimationmentioning

confidence: 99%

Hemodynamic investigation of a novel rotary displacement blood pump for extracorporeal membrane oxygenation

Xue

Ren

Gao

et al. 2023

Numer Methods Biomed Eng

View full text Add to dashboard Cite

Extracorporeal membrane oxygenation (ECMO) is a life support system used in the treatment of severe respiratory and circulatory failure. High shear stress caused by the high rotational speed of centrifugal blood pumps can cause hemolysis and platelet activation, which are among the major factors leading to the complications of the ECMO system. In this study, a novel blood pump named rotary displacement blood pump (RDBP), which can considerably reduce rotational speed and shear stress while ensuring the normal pressure flow relationship, was proposed. We employed computational fluid dynamics (CFD) analysis to investigate the performance of RDBP under adult ECMO support operating conditions (5 L/min with 350 mmHg). The efficiency and H‐Q curves of the RDBP were calculated to evaluate its hydraulic performance, and pressure, flow patterns, and shear stress distribution were analyzed to estimate the hemodynamic characteristics in the pump. In addition, the modified index of hemolysis (MIH) was calculated for the RDBP based on a Eulerian approach. The hydraulic efficiency of the RDBP was 47.28%. The velocity distribution of flow field in the pump was relatively uniform. Most of the liquid (more than 75%) in the pump was exposed to low scale shear stress (<1 Pa), which was close to normal physiological conditions. The gap area was the main distribution location of high scale shear stress. The high wall shear stress (>9 Pa) volume fraction of the RDBP was small and located in the boundary areas between the rotor's edge and the housing. The MIH value of the RDBP was 9.87 ± 0.93 (mean ± SD). The RDBP can achieve better hydraulic efficiency and hemodynamic performance at lower rotational speed. The design of this novel pump is expected to provide a new direction for developing a blood pump for ECMO.

show abstract

“…Thamsen et al combined the CFD method with particle image velocimetry to study the flow field of the HeartMate 3 (9). Chang et al used CFD to study the mechanical and hemolytic performance of four different commercial centrifugal pumps (10).…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic evaluation and in vitro hemolysis evaluation of a novel centrifugal pump for extracorporeal membrane oxygenation

Fu¹,

Liu²,

Wu³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: The STM CP-24 I centrifugal pump is a newly developed centrifugal pump for extracorporeal membrane oxygenation equipment. This study aimed to combine hydraulic experiments, hemodynamic numerical simulations, and standard in vitro hemolysis experiments to investigate the comprehensive performance of this centrifugal pump. Methods:In vitro experiments were first done to obtain the pressure-flow data of the centrifugal pump in its working range to evaluate its hydraulic performance. Next, the commonly used clinical working points were selected as boundary conditions, and a computational fluid dynamics method was applied to evaluate its hemodynamic performance. The blood pressure distribution, blood flow fields, and high-wall-shear-stress zones in the centrifugal pump were determined as indicators for hemodynamic evaluation. Finally, standard in vitro hemolysis experiments were performed to test the blood compatibility of this centrifugal pump (n=3 blood samples). In addition, its blood compatibility was evaluated in the form of the normalized index of hemolysis (NIH).Results: The pressure-flow curve of the centrifugal pump showed that the head pressure and flow of the centrifugal pump showed a mostly linear relationship within the whole working range. When the rotation speed of the centrifugal pump was 5,500 rpm, it achieved a hydraulic performance of 550 mmHg head pressure and 8 L/min output flow, which could meet the clinical needs of extracorporeal membrane oxygenation. Analysis of computational fluid dynamics data indicated that the centrifugal pump had excellent hemodynamic performance: even distribution of blood pressure in the pump, no blood flow stagnation zone or dead zone in the overall flow field, and secondary flows in the gap between the rotor and the volute that significantly reduced the volume of the low-blood-flow zone close to the impeller. There was no obvious high-shear-stress zone on the surface of the volute or the impeller, which will effectively reduce the risk of thrombosis. In vitro hemolysis experiments indicated that the centrifugal pump had excellent blood biocompatibility, with a NIH =0.0125±0.0022 g/100 L. Conclusions:The STM CP-24 I centrifugal pump has excellent hydraulic performance, a reasonable design of the hemodynamic structure of the blood pump, and excellent blood compatibility. Therefore, it can meet clinical needs.

show abstract

A Numerical Study on Mechanical Performance and Hemolysis for Different Types of Centrifugal Blood Pumps

Cited by 4 publications

References 21 publications

Development of a Centrifugal Blood Pump for Ecmo and Vad Operations

Development of a Centrifugal Blood Pump for Ecmo and Vad Operations

Hemodynamic investigation of a novel rotary displacement blood pump for extracorporeal membrane oxygenation

Hemodynamic evaluation and in vitro hemolysis evaluation of a novel centrifugal pump for extracorporeal membrane oxygenation

Contact Info

Product

Resources

About