A numerical investigation of microwave ablation on porous liver tissue

Abstract

The understanding of heat transport in biological tissues is important for enhanced insight on the physiological mechanisms and thermoregulatory mechanisms. This article presents a numerical simulation of microwave (MW) ablation using a single-slot MW antenna on two layers of porous liver tissue. The two layers are of tumor and normal tissue. A porous media approach is proposed for mathematical model of MW ablation. Three coupled models which include transient momentum equations and a transient energy equation coupled with an electromagnetic wave propagation (EWP) equation are analyzed. This article focuses on the influences of the tumor diameter, tumor porosity, and input MW power on the specific absorption rate (SAR) profile, temperature profile, and blood velocity profile within the porous liver tissue. The results obtained from the calculation of porous media model are examined and compared with the one of bioheat model along with the experimental results from previous work. The results indicated that all parameters have a significant effect on the SAR profile, temperature profile, and blood velocity profile in the porous liver tissue. The advanced results in this research can be used in applications such as it provides guidance on the practical treatment and can be developed medically for therapeutic.

Coupled thermo-electro-mechanical models for thermal ablation of biological tissues and heat relaxation time effects

“…Existing experimental studies available in literature have highlighted that the exposure of biological tissue to elevated temperatures (> 50 o C) during thermal ablative procedures can result in varying degree of mechanical deformation (including both expansion and contraction) within the tissue [24][25][26][27][28][29][30][31][32][33][34][35][36]. Several computational studies have also been reported to capture such mechanical deformations, but mainly limited to only thermal expansion [37][38][39][40][41][42][43]. Importantly, ignorance of the impact of tissue contraction/shrinkage during thermal ablative procedures has resulted in significant underestimation of the predicted ablation volume (see, e.g.…”

“…where ωb = 0.016 s -1 [12] is the baseline blood perfusion rate of the tissue. for hygienic and guidance purpose [37][38]. A continuous MWA procedure has been performed with the input MW power of 10-60 W for a duration of 10 minutes at the microwave antenna frequency of 2.45 GHz [38,44].…”

“…for hygienic and guidance purpose [37][38]. A continuous MWA procedure has been performed with the input MW power of 10-60 W for a duration of 10 minutes at the microwave antenna frequency of 2.45 GHz [38,44]. The outer surface of the computational domain for the MWA model has been subjected to scattering boundary conditions, i.e., the electromagnetic wave can pass through the boundary without reflection.…”

“…Thermal insulation boundary condition has been applied at the antenna-tissue interface and outer boundaries of the biological tissue during the MWA procedure and presented in Fig. 1(a) [see e.g., [17,[37][38] for relevant motivation].…”

Modelling of combination therapy using implantable anticancer drug delivery with thermal ablation in solid tumor

“…Darcy law is derived for incompressible Newtonian fluid with neglecting the following factors: the divergence of the velocity, the inertial force, and the friction within the fluid and between the fluid and solid phases. Similar to other works in the literature 35,36 , the fluid flow in the tumor tissue with thermal ablation can be modelled using Darcy law.…”