A nuclear polymorphism at the 8q24 region is associated with improved survival time and chemo‑response in high‑grade serous ovarian cancer

Abstract

The 8q24 chromosomal region is strongly associated with an increased risk of ovarian cancer. One single nucleotide polymorphism that is associated with ovarian cancer in this region is rs6983267, located within the long non-coding RNA colon cancer associated transcript 2 (CCAT2). The aim of the present study was to assess the association between rs6983267 and clinical outcomes in patients with high-grade serous ovarian cancer (HGSOC). The present retrospective genetic association study utilized Sanger sequencing to determine the genotype at the rs6983267 locus (GG, GT, TT) in 98 patients with HGSOC. Survival time and chemotherapy responses between patients were compared with the TT genotype and patients with a genotype containing a G allele (GT, GG). Survival analyses were performed using Cox proportional hazard ratio analysis. Association with chemo-response was performed using a logistic regression. The results revealed that patients with HGSOC and the TT genotype at the rs6983267 locus had improved survival time compared with patients with genotypes containing a G allele [hazard ratio=0.59; 95% confidence interval (CI), 0.36–0.97; P=0.039] and were significantly associated with International Federation of Gynecology and Obstetrics stage [odds ratio (OR)=5.34; 95% CI, 1.50–22.62; P=0.014] and positive chemo-response (OR=4.51; 95% CI, 1.40–18.00; P=0.018). In summary, patients with HGSOC and the TT genotype at the rs6983267 locus had improved survival time compared with those with a G allele, despite being associated with more advanced disease; this was possibly due to an improved response to chemotherapy.

Upregulation of the long noncoding RNA GJA9‐MYCBP and PVT1 is a potential diagnostic biomarker for acute lymphoblastic leukemia

“…51 As an important lncRNA, MYCBP2-AS1 is associated with improved survival time and chemoresponse in high-grade serous ovarian cancer. 52 Despite some research on how MYCBP-related lncRNAs may contribute to human diseases, the exact roles of GJA9-MYCBP in the pathophysiology of leukemia are still blanketed in mystery. Herein, we showed that in ALL samples, GJA9-MYCBP was upregulated in patients' samples compared to the healthy ones.…”

“…The upregulation of MYCBP promoted the invasion and migration of gastric cancer cells 51 . As an important lncRNA, MYCBP2‐AS1 is associated with improved survival time and chemo‐response in high‐grade serous ovarian cancer 52 . Despite some research on how MYCBP‐related lncRNAs may contribute to human diseases, the exact roles of GJA9‐MYCBP in the pathophysiology of leukemia are still blanketed in mystery.…”

Upregulation of the long noncoding RNA GJA9-MYCBP and PVT1 is a potential diagnostic biomarker for Acute Lymphoblastic Leukemia

“…The upregulation of MYCBP promoted the invasion and migration of gastric cancer cells [51]. As an important lncRNA, MYCBP2-AS1 is associated with improved survival time and chemoresponse in high-grade serous ovarian cancer [52]. Despite some research on how MYCBP-related lncRNAs may contribute to human diseases, the exact roles of GJA9-MYCBP in the pathophysiology of leukemia are still blanketed in mystery.…”

Correlation Between Long non-coding RNA SOX2OT rs9839776 C>T Polymorphism and Unexplained Recurrent Miscarriages

“…There are studies showed that the lncRNA CCAT2 rs6983267 polymorphism is significantly correlated with an increased possibility of ovarian cancer(J. Han et al, 2017) (Ikoma et al, 2021) and an increased risk of prostate cancer(M. Zhu et al, 2017). Further research discovered that rs6983267 had a slight connection with breast cancer (He et al, 2017).…”