A NSQIP Review of Major Morbidity and Mortality of Synchronous Liver Resection for Colorectal Metastasis Stratified by Extent of Liver Resection and Type of Colorectal Resection

Shubert, Christopher R.; Habermann, Elizabeth B.; Bergquist, John R.; Thiels, Cornelius A.; Thomsen, Kristine M.; Kremers, Walter K.; Kendrick, Michael L.; Cima, Robert R.; Nagorney, David M.

doi:10.1007/s11605-015-2895-z

Cited by 78 publications

(36 citation statements)

References 39 publications

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“…In a study using the ACS-NSQIP database, the overall rate of severe morbidity was 29% in all patients who underwent simultaneous resection (48). This figure is comparable to the morbidity rate (major and minor) in the current study.…”

Section: Resultssupporting

confidence: 76%

Simultaneous resection for colorectal cancer with synchronous liver metastases is a safe procedure: Outcomes at a single center in Turkey

Dulundu

Attaallah

Tilki

et al. 2017

BST

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Section: Resultssupporting

confidence: 76%

Simultaneous resection for colorectal cancer with synchronous liver metastases is a safe procedure: Outcomes at a single center in Turkey

Dulundu

Attaallah

Tilki

et al. 2017

BST

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“…A similar concern about bias applies to collaborative reports from hospitals willing to participate in a programme like the monitored survey of a selected group of US hospitals collaborating in the National Surgical Quality Improvement Program database. Analysis of the years 2005–2007 showed a mortality rate of between 0·9 and 2·2 per cent for liver resections, and 5 per cent in simultaneous colorectal and hepatic resections.…”

Section: Discussionmentioning

confidence: 99%

Mortality after liver surgery in Germany

Filmann

Walter

Schadde

et al. 2019

British Journal of Surgery

113

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Background: Mortality rates after liver surgery are not well documented in Germany. More than 1000 hospitals offer liver resection, but there is no central regulation of infrastructure requirements or outcome quality.Methods: Hospital mortality rates after liver resection were analysed using the standardized hospital discharge data (Diagnosis-Related Groups, ICD-10 and German operations and procedure key codes) provided by the Research Data Centre of the Federal Statistical Office and Statistical Offices of the Länder in Wiesbaden, Germany.Results: A total of 110 332 liver procedures carried out between 2010 and 2015 were identified. The overall hospital mortality rate for all resections was 5⋅8 per cent. The mortality rate among 17 574 major hepatic procedures was 10⋅4 per cent. Patients who had surgery for colorectal liver metastases (CRLMs) had the lowest mortality rate among those with malignancy (5⋅5 per cent), followed by patients with gallbladder cancer (7⋅1 per cent), hepatocellular carcinoma (9⋅3 per cent) and intrahepatic cholangiocarcinoma (11⋅0 per cent). Patients with extrahepatic cholangiocarcinoma had the highest mortality rate (14⋅6 per cent). The mortality rate for extended hepatectomy was 16⋅2 per cent and the need for a biliodigestive anastomosis increased this to 25⋅5 per cent. Failure to rescue after complications led to mortality rates of more than 30 per cent in some subgroups. There was a significant volume-outcome relationship for CRLM surgery in very high-volume centres (mean 26-60 major resections for CRLMs per year). The mortality rate was 4⋅6 per cent in very high-volume centres compared with 7⋅5 per cent in very low-volume hospitals (odds ratio 0⋅60, 95 per cent c.i. 0⋅42 to 0⋅77; P < 0⋅001).Conclusion: This analysis of outcome data after liver resection in Germany suggests that hospital mortality remains high. There should be more focused research to understand, improve or justify factors leading to this result, and consideration of centralization of liver surgery.

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“…Synchronous resection increases the complexity of the surgical procedure, and it is therefore notable that patients selected for a simultaneous approach tended to be older and have a higher ASA grade than patients undergoing alternative approaches. The safety of simultaneous resection when involving a minor resection in combination with high‐ or low‐risk CRC resection has been demonstrated and it may be considered clinically appropriate to offer this strategy to higher‐risk patients with low‐volume liver disease to avoid the cumulative morbidity and mortality of separate interventions. Differences in the extent of liver metastases, age and comorbidities between patients undergoing each surgical strategy may act to cancel each other out, resulting in similar survival between the unmatched groups.…”

Section: Discussionmentioning

confidence: 99%

The timing of liver resection in patients with colorectal cancer and synchronous liver metastases: a population‐based study of current practice and survival

et al. 2018

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A NSQIP Review of Major Morbidity and Mortality of Synchronous Liver Resection for Colorectal Metastasis Stratified by Extent of Liver Resection and Type of Colorectal Resection

Cited by 78 publications

References 39 publications

Simultaneous resection for colorectal cancer with synchronous liver metastases is a safe procedure: Outcomes at a single center in Turkey

Simultaneous resection for colorectal cancer with synchronous liver metastases is a safe procedure: Outcomes at a single center in Turkey

Mortality after liver surgery in Germany

The timing of liver resection in patients with colorectal cancer and synchronous liver metastases: a population‐based study of current practice and survival

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