A novel wound dressing based on epigallocatechin-3-gallate self-assemble hydrogels promotes effects on wound healing

A novel wound dressing based on a gold nanoparticle self-assembled hydrogel to promote wound healing

“…Based on the existing work base of our laboratory, under the method of solid-state synthesis, Fmoc-Tyr ( t Bu)-OH was connected to 2-trichloroyl chloride resin with multiple active sites by dehydration condensation. 18 Then, the unreacted active sites on the resin were sealed with methanol, and two fmoc-fe-OH and 2-naphthoacetic acid were connected to obtain NapFFY resin. Additionally, 300 mL DCM containing 1% TFA was added to separate NapFFY from the resin.…”

“…16,17 Many of these gels collectively form a supramolecular gel. 18 In the past 20 years, these gels with supramolecular biological functions have been widely used in wound healing, drug delivery, and functional material design. [19][20][21] For example, the high-strength and injectable supramolecular hydrogel designed and prepared by Wang's research team has unique therapeutic effects on wound healing after tooth extraction.…”

Recent advances in targeted nanoparticle drug delivery systems for ischaemic stroke

“…Such NPs can release therapeutic components in response to a specific stimulus in the environment. 53,54 Things like magnetism, light, sound, a certain range of pH, oxidative stress, enzymes. The clinical application of nanotechnology is mainly reflected in diagnosis and treatment.…”

A review of past promises, present realities and a vibrant future for wound dressing from naturally occurring to sustainable materials

“…The 1 : 2 EGCG–NapFFY helped in decreasing the wound area, which was made by making an incision of 1 cm in mice that were anesthetized by intraperitoneal injection of 0.5% pentobarbital sodium and proved that this hydrogel can be used for wound healing. 120 Fiber matrices of HA/PLGA-E core/shell prepared by electrospinning hyaluronic acid (HA), poly(lactic- co -glycolic acid (PLGA) and EGCG were used to explore wound healing in streptozotocin-induced diabetic rats and normal rats and the rate was accelerated with the HA/PLGA-E matrices and can be considered as a novel scaffold for diabetic wound healing. 121 3-Acrylamido phenylboronic acid (APBA) with EGCG formed boronic esters as crosslinkers to form the E–A complex and this was further used to prepare the EACPA E–A complex-based polyacrylamide hydrogel by a one-pot radical copolymerization with acrylamide (AM) in the presence of N , N , N , N -tetramethyl ethylene-1,2-diamine (TEMED) and ammonium persulfate (APS) (as depicted in Fig.…”