A novel Vancomycin‐Functionalized‐Magnetic Graphene Composite for Use as a Near‐Infrared‐Induced Synergistic Chemo‐Photothermal Antibacterial

Abstract

Antibiotic-resistant bacterial strains are a major cause of disease. They continue to remain a challenge in the clinic particularly in the vision system. For example, infectious endophthalmitis is a major blind-causing disease caused by bacteria. A highly efficient synergistic antibacterial treatment that uses a photothermal antibacterial therapeutic with a chemo-antibacterial therapeutic in a multifunctional nanocomposite is reported. It is prepared by immobilizing vancomycin onto the surface of a magnetic chitosan-graphene (VCM-MCG) composite. An antibacterial effect is achieved when VCM-MCG is applied. This effect is enhanced when the nanocomposites are irradiated with a near-infrared laser. Growth of gram-positive methicillin-resistant Staphylococcus aureus and gram-negative Escherichia coli bacteria are suppressed efficiently. Such a composite can help manage the control of pathogenic bacteria growth in the clinic.

Biomedical applications and prospects of temperature‐orchestrated photothermal therapy

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“…PTT was combined with traditional antibiotics to act on drug-resistant bacteria, hoping to find a way to reuse and prolong the working life of the old antibiotics. 201,202 In the study of Tan et al, red phosphorus (RP) is used as a PTA in combination with a variety of were eradicated The tumor size was significantly inhibited [182] Abbreviations: PTT, photothermal therapy; ROS, reactive oxygen species; RT, radiotherapy.…”