A novel use of methylene blue as a pharmacological tool

Shah, Dhvanit I.; Santani, D. D.; Goswami, Sunita

doi:10.1016/j.vascn.2005.12.003

Cited by 13 publications

(11 citation statements)

References 16 publications

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“…, a synthetic drug is known to uncouple ATPases [28] and generate superoxide radical ions. MB has been used as an ulcerogenic agent to study antiulcer agents and their mechanisms of action.…”

Section: Methylene Blue-induced Ulcer Methylene Blue (Mb)mentioning

confidence: 99%

In VivoModels Used for Evaluation of Potential Antigastroduodenal Ulcer Agents

Adinortey

Ansah

Galyuon

et al. 2013

Ulcers

174

138

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Peptic ulcer is among the most serious gastrointestinal diseases in the world. Several orthodox drugs are employed for the treatment of the disease. Although these drugs are effective, they produce many adverse effects thus limiting their use. In recent years, there has been a growing interest in alternative therapies, especially those from plants due to their perceived relative lower side effects, ease of accessibility, and affordability. Plant medicines with ethnomedicinal use in peptic ulcer management need to be screened for their effectiveness and possible isolation of lead compounds. This requires use of appropriate animal models of various ulcers. The limited number of antiulcer models for drug development against gastric and duodenal ulcer studies has hindered the progress of targeted therapy in this field. It is, therefore, necessary to review the literature on experimental models used to screen agents with potential antigastroduodenal ulcer activity and explain their biochemical basis in order to facilitate their use in the development of new preventive and curative antiulcer drugs. Clinical trials can then be carried out on agents/drugs that show promise. In this paper, currentin vivoanimal models of ulcers and the pathophysiological mechanisms underlying their induction, their limitations, as well as the challenges associated with their use have been discussed.

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Section: Methylene Blue-induced Ulcer Methylene Blue (Mb)mentioning

confidence: 99%

In VivoModels Used for Evaluation of Potential Antigastroduodenal Ulcer Agents

Adinortey

Ansah

Galyuon

et al. 2013

Ulcers

174

138

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“…At the cellular level, MB modulates the functions of various integral membrane proteins involved in transports of solutes such as glucose (Louters et al, 2006; Scott et al, 2009) and ions such as Na + , K + , and H + (Puppi et al, 1986; Sanders et al, 1989; Visarius et al, 1997; Shah et al, 2006; Furian et al, 2007). In addition, the functions of voltage-sensitive Na + (Oxford, 1977; Starkus et al, 1984; 1993; Kress et al, 1997), Ca 2+ (Thuneberg, 1990) and Ca 2+ -activated K + channels (Nemeth et al, 1985; Stockand and Samson, 1996; Saitow and Nakaoka, 1997) are also modulated by MB.…”

Section: Molecular Targets Of Methylene Bluementioning

confidence: 99%

Cellular and molecular actions of Methylene Blue in the nervous system

Öz

Lorke

Al‐Hasan

et al. 2010

Medicinal Research Reviews

349

249

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Methylene Blue (MB), following its introduction to biology in the 19 th century by Ehrlich, has found uses in various areas of medicine and biology. At present, MB is the first line of treatment in methemoglobinemias, is used frequently in the treatment of ifosfamide-induced encephalopathy, and is routinely employed as a diagnostic tool in surgical procedures. Furthermore, recent studies suggest that MB has beneficial effects in Alzheimer's disease and memory improvement. Although the modulation of the cGMP pathway is considered the most significant effect of MB, mediating its pharmacological actions, recent studies indicate that it has multiple cellular and molecular targets. In the majority of cases, biological effects and clinical applications of MB are dictated by its unique physicochemical properties including its planar structure, redox chemistry, ionic charges, and light spectrum characteristics. In this review article, these physicochemical features and the actions of MB on multiple cellular and molecular targets are discussed with regard to their relevance to the nervous system.

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“…In a study which investigated substrate binding to muscarinic receptors, as well as esterase activity of human and bovine plasma, MB was found to inhibit specific binding of radiolabeled substrate to muscarinic receptors and to inhibit esterase activity [35]. At even higher concentrations (10-25 mM), MB can increase ATPase activity in vitro [36]. In addition, recent in vitro studies using high MB concentrations indicate that it can prevent the aggregation of tau filaments and amyloid deposition characteristic of Alzheimer's brains [37][38][39].…”

Section: Mb's Hormetic Dose-response Effects On Various Biochemical Vmentioning

confidence: 99%

Behavioral, Physiological and Biochemical Hormetic Responses to the Autoxidizable Dye Methylene Blue

Bruchey¹,

González-Lima²

2008

American J. of Pharmacology and Toxicology

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The goals of this review were to identify methylene blue (MB) as a compound that follows hormetic behavior for a wide range of effects and to address the question of what is unique about MB that could account for its wide applicability and hormetic behavior as a drug. The MB hormetic doseresponse relationship is exemplified by an increase in various behavioral, physiological and biochemical responses with increasing dose, followed by a decrease in the same responses with an even higher dose, until the responses are equal to control responses. With MB doses increasing beyond the hormetic zone, the responses decrease even further, until they are below the control responses. At doses spanning its hormetic zone, MB can increase select responses until they are 130-160% of control. For example, low doses of MB produce maximum behavioral and biochemical responses with averages of approximately 140% of control. As MB dose is raised outside the hormetic zone the response decreases below the control response, as exemplified by MB's ability to increase cytochrome oxidase activity at intermediate doses, while decreasing cytochrome oxidase activity at higher doses. It is proposed that MB's autoxidizable chemical property may be responsible for its unique biological action as both a metabolic energy enhancer and antioxidant that is frequently characterized by hormetic dose-response relationships.

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A novel use of methylene blue as a pharmacological tool

Cited by 13 publications

References 16 publications

In VivoModels Used for Evaluation of Potential Antigastroduodenal Ulcer Agents

In VivoModels Used for Evaluation of Potential Antigastroduodenal Ulcer Agents

Cellular and molecular actions of Methylene Blue in the nervous system

Behavioral, Physiological and Biochemical Hormetic Responses to the Autoxidizable Dye Methylene Blue

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