A Novel Use of Complete Denture Prosthesis as Mandibular Advancement Device in the Treatment of Obstructive Sleep Apnea in Edentulous Subjects

Abstract

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Incidence of Obstructive Sleep Apnea in Elderly Edentulous Patients and the Possible Correlation of Serum Serotonin and Apnea‐Hypopnea Index

“…In accordance with the limitations of this study, the following conclusions were drawn: The overall incidence of OSA in elderly edentulous patients was found to be 40.94% (32.03% male, 8.91% female). An inverse correlation between OSA severity (as estimated by AHI, RERA, and RDI scores) and serum serotonin level was validated in this study. Use of complete dentures modified to function as MAD led to a reduction in AHI, RERA, and RDI scores and an elevation in serum serotonin levels. A previous proposal to consider estimation of serum Serotonin (5‐Hydroxytryptamine‐5HT) as a viable tool to diagnose OSA was reaffirmed from the results of this study. …”

“…The modified MAD positions the mandible forward during sleep, effects pharyngeal expansion, and thereby helps reduce the severity of OSA. OSA cannot be completely cured by using this device . The results of the present study revealed that the number of patients with mild OSA increased with time, whereas the number of patients with moderate and severe OSA significantly decreased.…”

“…Variable results have been reported on the effect of complete dentures on OSA . The potential utility of a complete denture prosthesis modified as a mandibular advancement device (MAD) and worn during sleep at night has been demonstrated . Mandibular protrusion within the comforts of physiologic limits has shown to effectively control mild‐to‐moderate OSA in edentulous patients.…”

Obstructive Sleep Apnea and Neurocognitive Dysfunction in Edentulous Patients

“…Relating this to this study, it can be stated that this damage causes perinatal brain injury and leads to neurological dysfunction which, in turn, alters the homeostasis of the body and brings about reduced ventilatory control during sleep and subsequent collapse of the pharyngeal airway. Thus, the relation between OSA and neurocognitive dysfunction found in the present study has strong support from previous research based on the findings of earlier studies . All patients of this study cohort were rehabilitated with complete dentures, which were used as MAD during sleep at night, and the reduction in severity of OSA and cognitive dysfunction was demonstrated.…”

“…The utility of a complete denture prosthesis modified for nocturnal use as a mandibular advancement device (MAD) has already been demonstrated . An increase in pharyngeal volume effected by this device has also been shown to effectively ameliorate OSA in edentulous patients …”