A novel urea sensitive biosensor with extended dynamic range based on recombinant urease and ISFETs

Солдаткин, А. П.; Montoriol, Jean; Sant, W.; Martelet, C.; Jaffrézic‐Renault, Nicole

doi:10.1016/s0956-5663(03)00175-1

Cited by 88 publications

(45 citation statements)

References 11 publications

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“…[452,453] The latter figure represents a sensitivity limit 10 4 -10 9 times below that afforded by state-of-the-art ion sensitive planar FETs. [454][455][456] Given the exquisite sensitivity of NW devices and the data provided in the section above on traditional FETs, [457][458][459][460][461][462] it would be logical to test NW FETs for detection of neural activity. Significantly, NW FETs can be used for measurements from extremely small areas of neurons, for instance at or below the level of a single axon or dendrite.…”

Section: Nanowire Field Effect Transistors For Neural Interfacementioning

confidence: 99%

Nanomaterials for Neural Interfaces

et al. 2009

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This review focuses on the application of nanomaterials for neural interfacing. The junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long‐term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems. This confluence of need, accumulated expertise, and potential impact on the well‐being of people suggests the potential of nanomaterials to revolutionize the field of neural interfacing. In this review, we begin with foundational topics, such as the current status of neural electrode (NE) technology, the key challenges facing the practical utilization of NEs, and the potential advantages of nanostructures as components of chronic implants. After that the detailed account of toxicology and biocompatibility of nanomaterials in respect to neural tissues is given. Next, we cover a variety of specific applications of nanoengineered devices, including drug delivery, imaging, topographic patterning, electrode design, nanoscale transistors for high‐resolution neural interfacing, and photoactivated interfaces. We also critically evaluate the specific properties of particular nanomaterials—including nanoparticles, nanowires, and carbon nanotubes—that can be taken advantage of in neuroprosthetic devices. The most promising future areas of research and practical device engineering are discussed as a conclusion to the review.

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Section: Nanowire Field Effect Transistors For Neural Interfacementioning

confidence: 99%

Nanomaterials for Neural Interfaces

et al. 2009

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“…Determination of blood urea nitrogen is an important routine test widely used in clinical laboratories. Several types of biosensors [2][3][4][5] are used for the detection and estimation of urea based on urease. Urease is an important part in most enzymatic sensors evolution to fulfil the growing requirement for the urea determination.…”

Section: Introductionmentioning

confidence: 99%

Selective determination of urea using urease immobilized on ZnO nanowires

Ali

Ibupoto

Salman³

et al. 2011

Sensors and Actuators B: Chemical

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Well-aligned zinc oxide (ZnO) nanowire arrays were fabricated on gold-coated plastic substrates using a low-temperature aqueous chemical growth (ACG) method. The ZnO nanowire arrays with 50-130 nm diameters and ~1 µm in lengths were used in an enzymebased urea sensor through immobilization of the enzyme urease that was found to be sensitive to urea concentrations from 0.1 mM to 100 mM. Two linear sensitivity regions were observed when the electrochemical responses (EMF) of the sensors were plotted vs. the logarithmic concentration range of urea from 0.1 mM to 100 mM. The proposed sensor showed a sensitivity of 52.8 mV/decade for 0.1-40 mM urea and a fast response time less than 4 s was achieved with good selectivity, reproducibility and negligible response to common interferents such as ascorbic acid and uric acid, glucose, K + and Na + ions.Index Terms: ZnO-nanowire arrays, electrochemical nanodevices, urease enzyme and urea determination.

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“…In 2004, reversible binding and unbinding events of single virus particles to antibody-modified NW-FETs was reported [22], showing the first time viruses could be detected at the single-particle level in real time and without the use of fluorescent labels. In 2005 [23] and 2007 [71], antibodies-conjugated NWs were also used to detect their specific antigen proteins at concentrations as low as 3 fM, which represents a sensitivity limit >10 4 times below that afforded by state-of-the-art ion planar FETs [72,73]. The NW-enabled nanotechnology truly represents a powerful and general platform for building functional interfaces between nanoelectronic systems and biological systems from proteins, viruses, to cells and tissues, opening up a number of opportunities in the merging field of integrated nanobiotechnology.…”

Section: Functional Nw Nanoelectronic-biological Interfacesmentioning

confidence: 99%

Assembly and integration of semiconductor nanowires for functional nanosystems

Lieber

2010

Pure and Applied Chemistry

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Central to the bottom-up paradigm of nanoscience, which could lead to entirely new and highly integrated functional nanosystems, is the development of effective assembly methods that enable hierarchical organization of nanoscale building blocks over large areas. Semiconductor nanowires (NWs) represent one of the most powerful and versatile classes of synthetically tunable nanoscale building blocks for studies of the fundamental physical properties of nanostructures and the assembly of a wide range of functional nanoscale systems. In this article, we review several key advances in the recent development of general assembly approaches for organizing semiconductor NW building blocks into designed architectures, and the further integration of ordered structures to construct functional NW device arrays. We first introduce a series of rational assembly strategies to organize NWs into hierarchically ordered structures, with a focus on the blown bubble film (BBF) technique and chemically driven assembly. Next, we discuss significant advances in building integrated nano electronic systems based on the reproducible assembly of scalable NW crossbar arrays, such as high-density memory arrays and logic structures. Lastly, we describe unique applications of assembled NW device arrays for studying functional nanoelectronic-biological inter faces by building well-defined NW-cell/tissue hybrid junctions, including the highly integrated NW-neuron interface and the multiplexed, flexible NW-heart tissue interface.

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A novel urea sensitive biosensor with extended dynamic range based on recombinant urease and ISFETs

Cited by 88 publications

References 11 publications

Nanomaterials for Neural Interfaces

Nanomaterials for Neural Interfaces

Selective determination of urea using urease immobilized on ZnO nanowires

Assembly and integration of semiconductor nanowires for functional nanosystems

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