A novel ultrasmall composite optical fiberscope

Oka, Kiyoshi; Seki, Takahiro; Naganawa, Akihiro; Kim, Keri; Chiba, Tadatoshi

doi:10.1007/s00464-010-1540-x

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…The second difficulty is that the charge-coupled device (CCD) camera-equipped cholangioscope typically used for treatment has a large diameter and cannot be advanced into intrahepatic bile ducts. To overcome this, a parallel-type ultra-small composite optical fiberscope (COF) was developed, through which transpapillary PDT was able to be applied to peripheral intrahepatic bile duct cancer (11,12). The COF used in the present study was equipped with a camera for observation with ordinary light and a laser irradiation hole, with a diameter <1 mm.…”

Section: Introductionmentioning

confidence: 99%

“…COF (OK Fiber Technology Co., Ltd., Kyoto, Japan) was used for laser radiation to miniature swine. This COF was independently developed as an endoscope by co-author Dr. Oka for this study as previously described (11,12), but with a smaller outer diameter. The outer diameter of the COF is <1 mm, and the scope has a light guide, holes for observation (10,000 pixels) and a photodynamic laser with a diameter of 0.4 mm (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Photodynamic therapy for biliary tract organ via a novel ultra‑small composite optical fiberscope

Kasuya

Oka²,

Soya

et al. 2017

Exp Ther Med

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Abstract. Photodynamic therapy (PDT) is a method used treat tumors via utilizing photodynamic reactions between photosensitive substances with tumor affinity and lasers. For overall bile duct cancers, PDT has been demonstrated to resolve stenosis and improve prognosis; however, when limited to intrahepatic bile duct cancers, modifications to the laser irradiation are necessary as surrounding hepatocytes incorporate a large amount of photosensitive substances. Furthermore, the intrahepatic bile duct is thin, and a guide sheath and thin fiber are necessary to transport laser irradiation probes to the target region. In the present study, a parallel-type ultra-small composite optical fiberscope (COF) with an outer diameter of 1 mm or smaller was developed to target a thin intrahepatic bile duct. PDT was performed using an animal model and talaporfin sodium (Laserphyrin), which is rapidly excreted by hepatocytes and is suitable for use with a long-wavelength laser due to its high tissue penetrating ability. The results demonstrated that Laserphyrin does not cause necrotic changes in the normal biliary tract mucosa. In addition, COF images of sufficient quality were acquired. The present results suggest that COF may be used for the treatment of deep bile duct lesions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%