A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film

Hu, Wenyuan; Chen, Shean-Jen; Huang, Kun‐Tsai; Hsu, Jin–Cherng; Chen, W. Y.; Chang, Guan‐Liang; Lai, Kuo-An

doi:10.1016/j.bios.2003.12.001

Cited by 78 publications

(41 citation statements)

References 22 publications

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“…6. LSPR sensor substrate with gold nanoparticles embedded in a dielectric layer on a thin gold film [35]. A 47.5-nm thick gold layer was initially deposited on a slide glass using a dc magnetron sputter.…”

Section: Colloidal Nanoparticle-enhanced Lspr Biosensorsmentioning

confidence: 99%

“…However, due to the difficulties in controlling and quantifying the volume fraction of the nanoparticles actually deposited on the film, alternative fabrication methods were developed in which gold nanoclusters were embedded in the dielectric film via an RF magnetron co-sputtering process. Using an SPR substrate with embedded gold nanostructures, DNA hybridization experiments presented an improved detection performance of approximately 0.1 pg/mm 2 [35]. This technique provides a feasible and reliable method to control the optimal size and volume fraction of the gold nanoclusters embedded in the dielectric film without the need for complex strategies to amplify the SPR angle shift.…”

Section: Nanoparticle-embedded Lspr Biosensorsmentioning

confidence: 99%

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Development of Nanostructured Plasmonic Substrates for Enhanced Optical Biosensing

Byun¹

2010

Journal of the Optical Society of Korea

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Plasmonic-based biosensing technologies have been successfully commercialized and applied for monitoring various biomolecular interactions occurring at a sensor surface. In particular, the recent advances in nanofabrication methods and nanoparticle syntheses provide a new route to overcome the limitations of a conventional surface plasmon resonance biosensor, such as detection limit, sensitivity, selectivity, and throughput. In this paper, optical and physical properties of plasmonic nanostructures and their contributions to a realization of enhanced optical detection platforms are reviewed. Following vast surveys of the exploitation of metallic nanostructures supporting localized field enhancement, we will propose an outlook for future directions associated with a development of new types of plasmonic sensing substrates.

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Section: Colloidal Nanoparticle-enhanced Lspr Biosensorsmentioning

confidence: 99%

Section: Nanoparticle-embedded Lspr Biosensorsmentioning

confidence: 99%

Development of Nanostructured Plasmonic Substrates for Enhanced Optical Biosensing

Byun¹

2010

Journal of the Optical Society of Korea

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“…To improve the performance of SPR sensors, sensitivity enhancement has been of tremendous interest in the development of these sensors. In recent years, modified SPR sensing systems, such as gold nanoparticles immobilized on a gold film [5], gold nanoparticleembedded dielectric layer on a gold film [6], and metallic nanowires regularly patterned on a metal film [7], have been proposed theoretically and experimentally. Enhanced sensing characteristics are mainly associated with shift or bending in dispersion relation of propagating surface plasmon, induced by its strong coupling with localized plasmon resonance modes in metallic nanostructures [8].…”

Section: Introductionmentioning

confidence: 99%

Nanopatterning Au chips for SPR refractometer by using interference lithography and chalcogenide photoresist

Dan’ko¹

2015

Semicond. Phys. Quantum Electron. Optoelectron.

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Abstract. This study reports on development of the interference lithography (IL) technique applying the resist based on chalcogenide glass films for fabrication of gold chips in the form of periodic surface nanostructures for surface plasmon resonance (SPR) refractometers. The IL technique was optimized for patterning the Au layers and formation of one-dimensional (grating) structures with the spatial frequency close to 3300 mm −1. The spatial frequency and depth of grating grooves were selected with account of the condition for Bragg reflection of plasmons at the operation wavelength of SPR refractometer and given environment (which is a condition for enhancing biosensor sensitivity as compared to that of a flat Au chip surface). It has experimentally been demonstrated that the use of diffraction patterns in SPR sensor increases its response by 17%. Keywords

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“…Unfortunately, when sensing biomolecules of low molecular weight or in low concentration, the variation in SPR angle is very small and this causes difficulties in detecting the acquired signal [6]. Hence, several researchers have focused on enhancement of sensitivity of biomolecular sensor.…”

Section: Introductionmentioning

confidence: 99%

Application of Surface Plasmon Resonance Based on a Metal Nanoparticle

Sadrolhosseini¹,

Noor²,

Moksin³

2012

Plasmonics - Principles and Applications

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A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film

Cited by 78 publications

References 22 publications

Development of Nanostructured Plasmonic Substrates for Enhanced Optical Biosensing

Development of Nanostructured Plasmonic Substrates for Enhanced Optical Biosensing

Nanopatterning Au chips for SPR refractometer by using interference lithography and chalcogenide photoresist

Application of Surface Plasmon Resonance Based on a Metal Nanoparticle

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