A Novel Tropoloisoquinoline Alkaloid, Neotatarine, from <i>Acorus calamus</i> L.

Li, Juan; Li, Zhao-Xing; Zhao, Jianping; Wang, Wei; Zhao, Xiaofang; Xu, Bo; Li, Lin; Zhang, Lan; Ren, Jie; Khan, Ikhlas A.; Li, Shunxiang

doi:10.1002/cbdv.201700201

Cited by 18 publications

(13 citation statements)

References 11 publications

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“…61 nelumbinis. 30 Compounds 93, 97, and 98 as well as asimilobine (109), isopiline (110), O-methylisopiline (111), glaucine (112), and norglaucine (113) were reported for the first time from Unonopsis floribunda 35,36 ( Figure 5). Compounds 97,98,109, and 112 were found in Unonopsis duckei, 59 and compounds 89, 96, 97, and 109 were reported from B. pleiosperma.…”

Section: F I G U R E 4 the Chemical Structures Of Compounds 57−84mentioning

confidence: 99%

“…Four "naphthalene-devoid" tetra-and dihydroisoquinolines, named ealaines A−D (18−21), were isolated from the Congolese plant Ancistrocladus ealaensis. 32 Akihisa et al 33 isolated noroxyhydrastinine Corydalis tomentella [28] 402 Oleracein E Portulaca oleracea [31] 403 Pipermullesine B Piper mullesua [108] 404 Pipermullesine C Piper mullesua [108] 405 Delavatine A Incarvillea delavayi [109] 406 Neotatarine Acorus calamus [110] Cryptocarya griffithiana, and Dehaasia longipedicellata, over the past 5 years. [34][35][36][37][38][39] (+)-N-Methylisococlaurine (24) also was found in Cryptocarya species and (−)-N-methylcoclaurine (25) was identified in the rhizomes of Sinomenium acutum in 2014.…”

Section: 4′-oo-didemethylancistrocladinium a (A/b)mentioning

confidence: 99%

“…It exhibited substantial cytotoxicity and anti‐inflammatory activities 158 . A novel tropoloisoquinoline alkaloid, neotatarine ( 406 ), was isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. in 2017 110 (Figure 23).…”

Section: Structure and Classification Of Isolated Isoquinoline Alkaloidsmentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

117

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Section: F I G U R E 4 the Chemical Structures Of Compounds 57−84mentioning

confidence: 99%

Section: 4′-oo-didemethylancistrocladinium a (A/b)mentioning

confidence: 99%

See 1 more Smart Citation

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

117

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“…The dehydro-derivative 15 of compound 13, known as -dolabrin, has also been obtained from the same source. 11 Stipitatic acid (16) 1b and its hydroxylated counterpart puberulic acid (17) are mold metabolites displaying pronounced antifungal effects. More recently the latter has been identified as a notable antimalarial agent 12,13 while its co-metabolite viticolin C ( 18) is much less active in this regard.…”

Section: Introductionmentioning

confidence: 99%

Troponoid Compounds as Therapeutic Agents and as Targets and Templates for Chemical Synthesis

Tan

Chen

Lan

et al. 2022

Synlett

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The renewed interest in troponoid compounds as potential therapeutic agents and the ongoing discovery of new, naturally-occurring and biologically active members of the class has resulted in an attendant focus on developing and deploying methods for their synthesis. This review highlights some of the significant recent developments in the area of troponoid chemistry that serve to contextualize our group’s longstanding and ongoing interest in the synthesis of such compounds through the cyclopropane-mediated ring-expansion of cyclohexanoid and benzenoid compounds. The various means by which such conversions can be accomplished and their application to the synthesis of both natural and non-natural troponoids are detailed.

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“…14,15 Probably, one reason A. calamus could treat these diseases was its neuroprotective bioactivities. Chemical investigation indicated it contains wide variety of sesquiterpenoids, [16][17][18][19] phenylpropanoids, lignans, alkaloids, 20 avonoids, steroids, triterpenoid saponins, and volatiles. [21][22][23] Among them, b-asarone, a phenylpropanoid, was reported mostly and regarded as the main neuroprotective constituent of A. calamus.…”

Section: Introductionmentioning

confidence: 99%