A novel triterpenoid saponin from Polygala tenuifolia Willd.

Abstract

A new triterpenoid saponin, tenuifoside A, was isolated together with three known triterpenoid saponins 2, 3, and 4 from the roots of Polygala tenuifolia Willd. With the help of chemical and spectral analyses (IR, MS, 1D-NMR, and 2D-NMR), the structure of the new saponin was elucidated as 3-O-beta-d-glucopyranosyl presenegenin 28-O-beta-d-xylopyranosyl-(1 --> 3)-beta-d-xylopyranosyl-(1 --> 4)-[beta-D-apiofuranosyl-(1 --> 3)]-alpha-L-rhamnopyranosyl-(1 --> 2)-[4-O-p-methoxycinnamoyl]-[alpha-l-rhamnopyranosyl-(1 --> 3)]-beta-d-fucopyranosyl ester (1). Three known triterpenoid saponins (2-4) were identified on the basis of spectroscopic data.

Efficacy and Safety of a Formulated Herbal Granula, Jiu Wei Zhen Xin, for Generalized Anxiety Disorder: A Meta‐Analysis

“…JWZXG contains nine herbs: Panax Ginseng (ginseng), Spina Date Seed (seed of wild jujube), Schisandra chinensis (the fruit of Chinese magnolia-vine), Poria cocos (hoelen), Radix Polygalae (root of Polygala tenuifolia Willd), Rhizoma Corydalis (corydalis tuber), Radix Asparagi (Cochinchinese Asparagus Root), Rehmannia glutinosa (prepared Rehmannia root), and Cinnamon (cassia bark). Furthermore, ginsenosides [ 18 ], saponins, flavones, alkaloids [ 19 , 20 ], dibenzocyclooctadiene lignans [ 21 ], polysaccharides [ 22 ], triterpenoid saponin [ 23 ], oligosaccharide ester [ 24 ], and 5-hydroxymethyl furfural [ 25 ] are the most active ingredients of these Chinese herbs mentioned above, and these ingredients are the markers for quality control.…”