A novel triphenylamine-based bis-Schiff bases fluorophores with AIE-Activity as the hydrazine fluorescence turn-off probes and cell imaging in live cells

Wang, Xinchao; Ding, Ge; Duan, Yuanke; Zhu, Yinjun; Zhu, Guangshi; Wang, Min; Li, Xiujuan; Zhang, Yanfen; Qin, Xiaozhuan; Hung, Cheung-Hin

doi:10.1016/j.talanta.2020.121029

Cited by 53 publications

(25 citation statements)

References 49 publications

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“…Hung and coworkers developed a series of fluorescent probes 35-38 based on a triphenylamine Schiff-base derivative to accurately detection of endogenous hydrazine in living systems. [113] In vitro experimental results demonstrated that probes 35 and 37 displayed brilliant AIE yellow fluorescence in DMF/H 2 O solution. In the presence of hydrazine, a chemical reaction occurred such that -CH = Nmoiety of probe transformed into a -CH 2 -NH-segment, resulting in weak fluorescence in aqueous solution due to the more highly hydrophilic reaction product.…”

Section: Aiegens For Hydrazinementioning

confidence: 97%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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Activity‐based approaches for designing AIEgens possess prominent advantages including high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention in recent years. Excellent activatable AIE probes have been reported for detecting toxic substances, imaging intracellular active molecules/biomolecules, as well as monitoring the activity of overexpressed enzymes in cancers. Moreover, the majority of activatable theranostic AIEgens can be specifically triggered in cancer cells and can kill these cells under light irradiation, while they have no distinct effect on normal cells, demonstrating satisfactory therapeutic selectivity that is superior to that of traditional chemotherapy. Thus, in this review, we systematically summarized the development of activatable AIE bioprobes in recent years from molecular design principles to biological applications. The challenges of activatable AIE probes and the corresponding solutions are described. We hope that the information provided in this review will facilitate the design of more activatable AIE probes to promote practical application of corresponding AIEgens.

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Section: Aiegens For Hydrazinementioning

confidence: 97%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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“…20) to recognize hydrazine. 113 Probes 89 and 90 in an aqueous solution of DMF exhibited fluorescence quenching at 560 nm upon the addition of hydrazine. Both had the same low detection limit of 55.1 nM.…”

Section: Fluorescent Probes Based On a Triphenylamine Platform For Ne...mentioning

confidence: 99%

Triphenylamine-based small-molecule fluorescent probes

2022

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“…The HeLa cells were incubated with probes C1 and C2. The results indicated that upon incubation with hydrazine there was the disappearance of fluorescence under a fluorescence microscope, suggesting that the presence of hydrazine makes the probe C1 and C2 applicable for the detection of hydrazine in live cells [ 101 ].…”

Section: Aie Active Molecules For Biological Cell Imagingmentioning

confidence: 99%

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

et al. 2021

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The emergence and development of aggregation induced emission (AIE) have attracted worldwide attention due to its unique photophysical phenomenon and for removing the obstacle of aggregation-caused quenching (ACQ) which is the most detrimental process thereby making AIE an important and promising aspect in various fields of fluorescent material, sensing, bioimaging, optoelectronics, drug delivery system, and theranostics. In this review, we have discussed insights and explored recent advances that are being made in AIE active materials and their application in sensing, biological cell imaging, and drug delivery systems, and, furthermore, we explored AIE active fluorescent material as a building block in supramolecular chemistry. Herein, we focus on various AIE active molecules such as tetraphenylethylene, AIE-active polymer, quantum dots, AIE active metal-organic framework and triphenylamine, not only in terms of their synthetic routes but also we outline their applications. Finally, we summarize our view of the construction and application of AIE-active molecules, which thus inspiring young researchers to explore new ideas, innovations, and develop the field of supramolecular chemistry in years to come.

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A novel triphenylamine-based bis-Schiff bases fluorophores with AIE-Activity as the hydrazine fluorescence turn-off probes and cell imaging in live cells

Cited by 53 publications

References 49 publications

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Triphenylamine-based small-molecule fluorescent probes

Recent Advances in Aggregation-Induced Emission Active Materials for Sensing of Biologically Important Molecules and Drug Delivery System

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