A novel trimodal system on a paper-based microfluidic device for on-site detection of the date rape drug “ketamine”

Yehia, Ali M.; Farag, Mohamed A.; Tantawy, Mahmoud A.

doi:10.1016/j.aca.2020.01.002

Cited by 64 publications

(48 citation statements)

References 52 publications

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“…Musile et al used this reagent in their microfluidic paper-based analytical devices (μPADs) for the multiplexed determination of different illicit drugs, including ketamine . Moreover, Yehia et al recently reported on a trimodal paper-based system including colorimetric, fluorometric, and potentiometric detection zones for the determination of ketamine in beverages …”

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confidence: 99%

Identifying Electrochemical Fingerprints of Ketamine with Voltammetry and Liquid Chromatography–Mass Spectrometry for Its Detection in Seized Samples

et al. 2020

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Herein, a straightforward electrochemical approach for the determination of ketamine in street samples and seizures is presented by employing screen-printed electrodes (SPE). Square wave voltammetry (SWV) is used to study the electrochemical behavior of the illicit drug, thus profiling the different oxidation states of the substance at different pHs. Besides, the oxidation pathway of ketamine on SPE is investigated for the first time with liquid chromatography−high-resolution mass spectrometry. Under the optimized conditions, the calibration curve of ketamine at buffer solution (pH 12) exhibits a sensitivity of 8.2 μA μM −1 , a linear relationship between 50 and 2500 μM with excellent reproducibility (RSD = 2.2%, at 500 μM, n = 7), and a limit of detection (LOD) of 11.7 μM. Subsequently, binary mixtures of ketamine with adulterants and illicit drugs are analyzed with SWV to investigate the electrochemical fingerprint. Moreover, the profile overlapping between different substances is addressed by the introduction of an electrode pretreatment and the integration of a tailor-made script for data treatment. Finally, the approach is tested on street samples from forensic seizures. Overall, this system allows for the on-site identification of ketamine by law enforcement agents in an easy-to-use and rapid manner on cargos and seizures, thereby disrupting the distribution channel and avoiding the illicit drug reaching the end-user.

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confidence: 99%

Identifying Electrochemical Fingerprints of Ketamine with Voltammetry and Liquid Chromatography–Mass Spectrometry for Its Detection in Seized Samples

et al. 2020

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“…A paper-based microfluidic device using C-dots-gold nanoparticles was applied for on-site detection of ketamine in beverages. 48 The PL intensities at 453 nm, when excited at 350 nm, remain almost constant over the pH range of 3.0-7.0. Upon addition of ketamine to C-dots-gold nanoparticles, aggregation of gold nanoparticles occurs, leading to PL restoration of C-dots.…”

Section: C-dots Based Pl Assaysmentioning

confidence: 93%

Photoluminescent carbon nanomaterials for sensing of illicit drugs: focus

Wei

Liang

et al. 2022

ANAL. SCI.

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The growth of illicit drugs is a serious social problem, putting great pressure on law enforcement officers to screen numerous suspicious samples at crime scenes. Although commercial colorimetric kits are available, they are limited to common illicit drugs. With increasing numbers of new psychoactive substances in the market, accurate and rapid screening assays are highly demanded. Carbon dots (C-dots) are photoluminescent (PL) carbon nanomaterials with unique properties of excellent stability against salt and photo-irradiation, low blinking, and biocompatibility. They can be prepared easily through various routes from numerous precursors.This Focus provides examples of C-dots based PL assays for screening illicit drugs. The drugs induce PL changes of C-dots mostly through electron transfer and energy transfer. Liquid-and solid-phase PL assays of C-dots can be applied for in-field screening, with advantages of rapidity, low cost, selectivity, and minimum color interference showing their great commercial potential.

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“…Colorimetric detection 49,50,60,70,76,77,80,84,92,95,99,[116][117][118][119][120][121][122][123][124][125][126] is the most commonly used detection method in paper chip analysis. This involves a chromogenic reaction when the sample solution in the area of measurement, the target material and reagent reaction cause the components to be detected as a colored material using the contrast color depth and relevance of the component concentration under test, quantitative or semi-quantitative analysis, and exploiting the specicity of the reaction to the guarantee system of higher selectivity.…”

Section: Colorimetric Test Methodsmentioning

confidence: 99%

“…9.3.1 Fluorescence detection method. The uorescence detection method 13,18,46,63,77,82,85,86,94,95,98,112,113,129 is mainly used in combination with microuidic systems. It is mainly used to determine the uorescence samples and uorescent markers by using the uorescence of some substances emitted by light irradiation.…”

Section: Optical Detection Methodsmentioning

confidence: 99%