A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats

Kitase, Yuma; Sato, Yoshiaki; Ueda, Kazuto; Suzuki, Toshihiko; Mikrogeorgiou, Alkisti; Sugiyama, Yasuo; Matsubara, Kazuki; Okabe, Yuka Tsukagoshi; Shimizu, Shinobu; Hirata, Hitoshi; Yukawa, Hiroshi; Baba, Yoshinobu; Tsuji, Masahiro; Takahashi, Yoshiyuki; Yamamoto, Akihito; Hayakawa, Masahiro

doi:10.1089/scd.2019.0221

Cited by 12 publications

(8 citation statements)

References 51 publications

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“…Controlling or altering microglial polarity is one of the targets for treating CNS injuries, including HIE. 38,39 We evaluated activated microglia (M1) after intraperitoneal administration of hUCB-MNCs. Our study revealed that hUCBCs reduced the number of ED1-(an M1 microglia marker) positive cells significantly 24 h after HI insult.…”

Section: Activated Microgliamentioning

confidence: 99%

“…Microglia can be divided into two distinct types depending on their pro‐inflammatory (M1) and anti‐inflammatory (M2) status. Controlling or altering microglial polarity is one of the targets for treating CNS injuries, including HIE 38,39 . We evaluated activated microglia (M1) after intraperitoneal administration of hUCB‐MNCs.…”

Section: Mechanism Of Ucbc Treatments For Hiementioning

confidence: 99%

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Diverse actions of cord blood cell therapy for hypoxic‐ischemic encephalopathy

Sato

Tsuji

2021

Pediatrics International

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Perinatal hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal death and permanent neurological deficits. However, effective treatments have not yet been established, except therapeutic hypothermia, which is not effective for severe HIE; therefore, developing a novel therapy for HIE is of the utmost importance. Stem cell therapy has recently been identified as a novel therapy for HIE. Among the various stem cell sources, ethical hurdles can be avoided by using stem cells that originate from non-embryonic or non-neural tissues, such as umbilical cord blood cells (UCBCs), which are readily available and can be exploited for autologous transplantations. Human UCBs are a rich source of stem and progenitor cells. Many recent studies have reported the treatment effect of UCBCs. Additionally, phase I clinical trials have already been conducted, showing this therapy's safety and feasibility. One advantage of stem cell therapies, including UCBC administration, is that they exert treatment effects through multifaceted mechanisms. According to the findings of several publications, replacement of lost cells, namely, engraftment and differentiation into neuronal cells, is not likely to be the main mechanism. However, the association between UCBCs and various mechanism of action, such as neurogenesis, angiogenesis, and anti-inflammation, has been suggested in many studies, and most mechanisms are due to growth factors secreted from UCBCs. These diverse actions of UCBC treatment are expected to exert a substantial effect on HIE, which has a complex injury mechanism.

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Section: Activated Microgliamentioning

confidence: 99%

Section: Mechanism Of Ucbc Treatments For Hiementioning

confidence: 99%

Diverse actions of cord blood cell therapy for hypoxic‐ischemic encephalopathy

Sato

Tsuji

2021

Pediatrics International

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“…In addition, BMSCs promoted the M2 microglial polarization in a rat middle cerebral artery occlusion (MCAO) model and suppressed neuroinflammation ( Yang et al, 2020 ). According to some recent studies, MSCs from human exfoliated deciduous teeth reduced neuroinflammation by shifting microglial polarization (M1 to M2) through exosome secretion and paracrine effects ( Li et al, 2017 ; Kitase et al, 2020 ). In addition to MSCs, transplantation of NSCs showed the function of promoting microglial phenotypic transition from M1 toward M2 phenotype in a study of traumatic brain injury.…”

Section: Immunomodulatory Effects Of Stem Cell Therapy Targeting Microgliamentioning

confidence: 99%

Shaping the Microglia in Retinal Degenerative Diseases Using Stem Cell Therapy: Practice and Prospects

Jin

Sha

Gao

2021

Front. Cell Dev. Biol.

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Retinal degenerative disease (RDD) refers to a group of diseases with retinal degeneration that cause vision loss and affect people’s daily lives. Various therapies have been proposed, among which stem cell therapy (SCT) holds great promise for the treatment of RDDs. Microglia are immune cells in the retina that have two activation phenotypes, namely, pro-inflammatory M1 and anti-inflammatory M2 phenotypes. These cells play an important role in the pathological progression of RDDs, especially in terms of retinal inflammation. Recent studies have extensively investigated the therapeutic potential of stem cell therapy in treating RDDs, including the immunomodulatory effects targeting microglia. In this review, we substantially summarized the characteristics of RDDs and microglia, discussed the microglial changes and phenotypic transformation of M1 microglia to M2 microglia after SCT, and proposed future directions for SCT in treating RDDs.

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“…SHED was injected into the right external jugular vein in HIE neonatal rats to find out the usefulness of these cells for HIE in a study by Kitase et al There was a significant improvement with elongation of the endurance time in a treadmill test. 19…”

Section: Hypoxic-ischemic Encephalopathy (Hie)mentioning

confidence: 99%

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

Baweja¹

2020

Int J Res Med Sci

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Dental stem cells have been found to have the ability to differentiate into nerve cells, adipose cells, chondrocytes, osteoblasts, myocytes, hepatocytes, and odontoblasts. They can be derived from permanent teeth or deciduous teeth. Stem cells from human exfoliated deciduous teeth (SHED) have a higher proliferation rate and higher osteogenic and neurogenic potential than dental pulp stem cells (DPSC). Therefore, SHEDs are an attractive cell source for tissue regeneration. A large plethora of in vitro and animal studies have been conducted in the last few decades that has demonstrated the potential uses of these cells for the treatment of oral and non-oral diseases. The aim of this article was to review the potential therapeutic applications of stem cells derived from human exfoliated deciduous teeth. A Medline search was done, including international literature, published in English between 2003 and 2020. In this area, further research is needed to ensure the applicability of SHED in the treatment of diseases in humans.

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A Novel Treatment with Stem Cells from Human Exfoliated Deciduous Teeth for Hypoxic-Ischemic Encephalopathy in Neonatal Rats

Cited by 12 publications

References 51 publications

Diverse actions of cord blood cell therapy for hypoxic‐ischemic encephalopathy

Diverse actions of cord blood cell therapy for hypoxic‐ischemic encephalopathy

Shaping the Microglia in Retinal Degenerative Diseases Using Stem Cell Therapy: Practice and Prospects

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

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