A Novel Treatment of Postherpetic Neuralgia Using Peppermint Oil

Davies, Simon; Harding, Louise; Baranowski, A.

doi:10.1097/00002508-200205000-00011

Cited by 68 publications

(38 citation statements)

References 15 publications

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“…This, combined with clinical reports that document the beneficial effects of menthol treatment in patients suffering from postherpetic neuralgia and irritable bowel syndrome (Pittler and Ernst, 1998;Davies et al, 2002), suggests that TRPM8 may also be an exciting new target for the development of novel analgesics and agents to treat a range of other conditions (Caterina et al, 1997;McKemy et al, 2002;Peier et al, 2002). To date, no selective TRPM8 antagonists have been reported; however, the recent article by Behrendt et al (2004), demonstrating that the TRPV1 antagonists BCTC (Valenzano et al, 2003) and capsazepine (Bevan et al, 1992;Valenzano et al, 2003) are also antagonists of mouse TRPM8, provides an exciting breakthrough in this field, providing the first (albeit nonselective) tools with which to study TRPM8 function.…”

Section: (2h)-carboxamide (Bctc) (2r)-4-(3-chloro-2-pyridinyl)-2-metmentioning

confidence: 96%

Conservation of Functional and Pharmacological Properties in the Distantly Related Temperature Sensors TRPV1 and TRPM8

Weil

Moore²,

Waite³

et al. 2005

Mol Pharmacol

146

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Members of the transient receptor potential (TRP) superfamily of ion channels have now been defined as molecular transducers capable of reproducing the spectrum of temperature sensation exhibited by mammals. Because of their pivotal role in sensory transduction, many of these channels represent good targets for drug discovery. With a view to gaining further insight into the functional and pharmacological properties of these channels, we have used the whole-cell patch-clamp technique to study the human cold-sensitive menthol receptor transient receptor potential melastatin 8 (TRPM8) and compared its behavior with that of its distant relative, the heat-sensitive capsaicin-gated transient receptor potential vanilloid 1 (TRPV1). It is remarkable to find that TRPM8, in addition to its behavior as an outwardly rectifying, nonselective cation channel, shares many functional and pharmacological properties with TRPV1. TRPM8 exhibits prominent time-and voltage-dependent behavior, a property that may underlie the conserved rectification or gating mechanisms exhibited by these channels. We also show that TRPM8 is modulated by ethanol but unlike TRPV1 is insensitive to extracellular acidification. There is also significant overlap in the antagonist pharmacology of these channels with many TRPV1 antagonists such as capsazepine, -{2-[ethyl(3-methylphenyl)amino]ethyl}-urea (SB-452533) exhibiting similar activity at TRPM8. Overall, the degree of pharmacological overlap between TRPV1 and TRPM8 has implications for the interpretation of studies conducted with these ligands to date and highlights a clear challenge for the design of selective TRP channel antagonists. Our finding that N-(3-methoxyphenyl)-4-chlorocinnamide (SB-366791), at least, represents an apparently selective antagonist for TRPV1 suggests that this goal is attainable.

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Section: (2h)-carboxamide (Bctc) (2r)-4-(3-chloro-2-pyridinyl)-2-metmentioning

confidence: 96%

Conservation of Functional and Pharmacological Properties in the Distantly Related Temperature Sensors TRPV1 and TRPM8

Weil

Moore²,

Waite³

et al. 2005

Mol Pharmacol

146

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“…He observed that topical ointment with peppermint oil (containing L-menthol) reduced pain in patients suffering from post-herpetic neuralgia and several studies have since substantiated the claim. 15,19,39,44,45,65 Today, L-menthol is widely used in ointments to counteract local inflammation, eczema and joint aches, in lozenges to relieve throat soreness and also in nasal sprays to decongest and de-inflame the upper airways in case of common colds and fl. Moreover, FDA has listed L-menthol as a local anesthetic, antipruritic and antitussive compound.…”

Section: Introductionmentioning

confidence: 99%

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Andersen

Gazerani

Arendt-Nielsen

2016

The Journal of Pain

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Drugs interacting with transient receptor potential channels are of great therapeutic potential. In the present study we established cutaneous pain and hyperalgesia using the TRPA1 agonist CA. Subsequently, we showed that the frequently used topical counterirritant and TRPM8 agonist, L-menthol, decreased evoked pain, hyperalgesia, and inflammation, indicating direct and indirect antinociceptive mechanisms.

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“…Furthermore, Davies et al [5] reported a case of a 76-yearold woman whose pain had been resistant to standard therapies. The application of peppermint oil to her skin resulted in a significant pain reduction, the duration of analgesia lasting 4 -6 hours post-application.…”

Section: Introductionmentioning

confidence: 99%

Effects of oral supplementation of mint extract on muscle pain and blood lactate

Sönmez

Çolak

Sönmez

et al. 2010

Biomedical Human Kinetics

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Study aim:To determine the effects of mint extract on muscle pain and blood lactate levels after a 400-m run. Material and methods: A group of 16 physical education students (mean age 21.81 ± 2.13 years) volunteered to participate in the study. The subjects were randomly assigned into 3 groups: mint, placebo or control. The mint group was given orally mint extract (5 ml/kg of body mass) and the placebo group was given unsweetened tea (5 ml/kg) in a double-blind fashion and cross-over design one hour before a 400-m running test. Subjects in the control group remained untreated. The effect of mint extract on muscle pain was recorded by an inquiry; blood lactate levels were measured after the running test. Results: Oral administration of mint extract significantly (p<0.01) decreased blood lactate concentrations but muscle pain levels remained unchanged in all groups. Conclusions: Oral administration of mint extract may have a beneficial effect on blood lactate clearance and therefore may increase athletic performance.

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A Novel Treatment of Postherpetic Neuralgia Using Peppermint Oil

Cited by 68 publications

References 15 publications

Conservation of Functional and Pharmacological Properties in the Distantly Related Temperature Sensors TRPV1 and TRPM8

Conservation of Functional and Pharmacological Properties in the Distantly Related Temperature Sensors TRPV1 and TRPM8

High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde

Effects of oral supplementation of mint extract on muscle pain and blood lactate

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