A Novel Translational Animal Model of Trigeminal Autonomic Cephalalgias

Akerman, Simon; Goadsby, Peter J.

doi:10.1111/head.12471

Cited by 11 publications

(12 citation statements)

References 61 publications

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“…Tear production, as well as pain, can be evoked by corneal stimulation. The reflex for tear production involves motor neurons within the superior salivatory nucleus (SSN), 8 which send projections to parasympathetic cholinergic motor neurons in the pterygopalatine ganglion (PPG) that innervate the lacrimal gland and evoke tear production through stimulation of the acini within the gland (Fig. 1, dotted lines).…”

mentioning

confidence: 99%

Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease

Aicher

Hermes

Hegarty

2015

Invest. Ophthalmol. Vis. Sci.

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Because only menthol responses were impaired, cold-sensitive corneal afferents appear to be selectively altered in our saporin DED model. Hypoalgesia is not due to reduced tear production, since we did not observe hypoalgesia in an atropine DED model. Corneal fiber density is unaltered in saporin DED animals, suggesting that molecular mechanisms of nociceptive signaling may be impaired. The saporin DED model will be useful for exploring the mechanism underlying corneal hypoalgesia.

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mentioning

confidence: 99%

Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease

Aicher

Hermes

Hegarty

2015

Invest. Ophthalmol. Vis. Sci.

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“…6,7 In TACs, hypothalamic activation and its influence through descending projections on the trigemino-cervical complex and the superior salivatory nucleus have been invoked to explain attacks occurrence. 8 In HH, previously defined as "alarm clock headache syndrome," the hypothalamic involvement might explain its strong chronobiological regularity. Further overlaps between SUNCT and HH involve the clinical pattern, in particular the circadian rhythmicity and cranial autonomic symptoms.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Coexistence of SUNCT and Hypnic Headache in the Same Patient

et al. 2016

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“…Knowledge about physiological aspects of the trigeminal system today is largely based on animal models (Akerman and Goadsby, 2015;Herta et al, 2017), cadaver studies (Ezure et al, 2001;Williams et al, 2003) or extrapolations from peripheral nerve functioning. Human studies are frequently limited to pathophysiology and lack proper study designs (Tanaka and Zhao, 2016;Goadsby et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Neurophysiological aspects of the trigeminal sensory system: an update

Cruyssen

Politis

2018

Reviews in the Neurosciences

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AbstractThe trigeminal system is one of the most complex cranial nerve systems of the human body. Research on it has vastly grown in recent years and concentrated more and more on molecular mechanisms and pathophysiology, but thorough reviews on this topic are lacking, certainly on the normal physiology of the trigeminal sensory system. Here we review the current literature on neurophysiology of the trigeminal nerve from peripheral receptors up to its central projections toward the somatosensory cortex. We focus on the most recent scientific discoveries and describe historical relevant research to substantiate further. One chapter on new insights of the pathophysiology of pain at the level of the trigeminal system is added. A database search of Medline, Embase and Cochrane was conducted with the search terms ‘animal study’, ‘neurophysiology’, ‘trigeminal’, ‘oral’ and ‘sensory’. Articles were manually selected after reading the abstract and where needed the article. Reference lists also served to include relevant research articles. Fifty-six articles were included after critical appraisal. Physiological aspects on mechanoreceptors, trigeminal afferents, trigeminal ganglion and central projections are reviewed in light of reference works. Embryologic and anatomic insights are cited where needed. A brief description of pathophysiology of pain pathways in the trigeminal area and recent advances in dental stem cell research are also discussed. Neurophysiology at the level of the central nervous system is not reviewed. The current body of knowledge is mainly based on animal and cadaveric studies, but recent advancements in functional imaging and molecular neuroscience are elucidating the pathways and functioning of this mixed nerve system. Extrapolation of animal studies or functioning of peripheral nerves should be warranted.

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A Novel Translational Animal Model of Trigeminal Autonomic Cephalalgias

Cited by 11 publications

References 61 publications

Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease

Denervation of the Lacrimal Gland Leads to Corneal Hypoalgesia in a Novel Rat Model of Aqueous Dry Eye Disease

Case Report: Coexistence of SUNCT and Hypnic Headache in the Same Patient

Neurophysiological aspects of the trigeminal sensory system: an update

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