A novel transcranial photobiomodulation device to address motor signs of Parkinson's disease: a parallel randomised feasibility study

Herkes, Geoffrey; McGee, Claire; Liebert, Ann; Bicknell, Brian; Isaac, Vivian; Kiat, Hosen; McLachlan, Craig S.

doi:10.1016/j.eclinm.2023.102338

Cited by 6 publications

References 28 publications

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Overcoming challenges of clinical cell therapies for Parkinson's disease with photobiomodulation

Chamkouri,

Si,

Chen

et al. 2024

Interdisciplinary Medicine

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Photobiomodulation (PBM) has emerged as a rapidly growing and innovative therapeutic method for various illnesses in recent years. Due to the irreversible nature of Parkinson's disease (PD), it has proven challenging to impede or postpone the progression of the disease. Despite research on pharmacological approaches to halt neuronal degeneration, the viability of these techniques has been called into doubt due to apprehensions over potential side effects and the ethical implications associated with the utilization of embryonic cell transplantation. Hence, developing an innovative therapeutic approach to halting neuronal degeneration and safeguarding neurons from this neurodegenerative disorder is imperative. This review examines the pathogenesis, challenges, and limitations of conventional PD therapies, allowing a closer examination of PBM's distinctive approach within this medical context. Delving into PBM's therapeutic mechanisms in the cells, the effects of different wavelengths on cell therapies in PD patients, and considerations for patient care administration to overcome traditional challenges, this study offers insights into its potential as a promising avenue for PD management.

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Overcoming challenges of clinical cell therapies for Parkinson's disease with photobiomodulation

Chamkouri,

Si,

Chen

et al. 2024

Interdisciplinary Medicine

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Can photobiomodulation be studied in vitro? Investigation on the interaction between cell culture medium and short-wavelength blue LED light

Magni,

Banchelli,

Ciaccheri

et al. 2024

Optical Interactions With Tissue and Cells XXXV

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Photobiomodulation therapy is successfully applied in several medical fields, despite the fact that mechanisms underlying photobiomodulation are not yet fully clear. Cell cultures are one of the most exploited tools to study the processes that regulate photobiomodulation, even if they have some limitation. One of the main problem arising when studying the interaction of light with cell culture, is the interaction between the electromagnetic radiation and the cell culture medium. This interaction can limit the feasibility and reliability of the experimental results. In previous studies conducted on different cell types isolated from skin tissue, we have shown that low doses of blue LED light interact with cells, increasing the outward currents, viability, and proliferation, but without increasing the reactive oxygen species and damaging the mitochondria. These studies were performed following different experimental protocols, irradiating the cells both in the culture medium and without the medium. In order to further clarify our findings, we are now exploring the possible interactions between the medium for cell cultures (Dulbecco Modified Eagle's Medium (DMEM)) and the electromagnetic radiation, irradiating medium samples with different doses of blue LED light (410-430 nm). The directly irradiated samples were then analyzed with Near-Infrared and Raman spectroscopy. Our results point out that the irradiated DMEM shows a a different spectral beahviour at high fluences (>40 J/cm 2 ); moreover, these modifications are correlated to the riboflavin component currently used in the medium.

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Photobiomodulation therapy in neurodegenerative diseases: mechanisms, clinical applications, and future directions

Woo

2024

Medical Lasers

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A novel transcranial photobiomodulation device to address motor signs of Parkinson's disease: a parallel randomised feasibility study

Cited by 6 publications

References 28 publications

Overcoming challenges of clinical cell therapies for Parkinson's disease with photobiomodulation

Overcoming challenges of clinical cell therapies for Parkinson's disease with photobiomodulation

Can photobiomodulation be studied in vitro? Investigation on the interaction between cell culture medium and short-wavelength blue LED light

Photobiomodulation therapy in neurodegenerative diseases: mechanisms, clinical applications, and future directions

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