A Novel TNM Classification for Colorectal Cancers based on the Metro-ticket Paradigm

Pei, Jun‐Peng; Zhang, Chun‐Dong; Fu, Xiang; Ba, Yi; Yue, Shuai; Zhao, Zhe‐Ming; Dai, Dong‐Qiu

doi:10.7150/jca.55097

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Finally, the M factor pertains to the presence of distant metastasis (M1a, spread to 1 other part of the body beyond the colon or rectum; M1b, spread to more than 1 part of the body other than the colon or rectum; and M1c, spread to the peritoneal surface). The three parameters are combined for the final staging [36] as shown in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

Tumor Progression from a Fibroblast Activation Protein Perspective: Novel Diagnostic and Therapeutic Scenarios for Colorectal Cancer

Rossetti,

Stanca,

Del Frate

et al. 2023

Diagnostics

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In 2020, the Global Cancer Observatory estimated the incidence of colorectal cancer (CRC) at around 10.7% coupled with a mortality rate of 9.5%. The explanation for these values lies in the tumor microenvironment consisting of the extracellular matrix and cancer-associated fibroblasts (CAFs). Fibroblast activation protein (FAP) offers a promising target for cancer therapy since its functions contribute to tumor progression. Immunohistochemistry examination of FAP, fibronectin ED-B, and CXCR4 in primary tumors and their respective synchronous and/or metachronous metastases along with semiquantitative analysis have been carried out on histological samples of 50 patients diagnosed with metastatic CRC. The intensity of FAP, articulated by both “Intensity %” and “Intensity score”, is lower in the first metastasis compared to the primary tumor with a statistically significant correlation. No significant correlations have been observed regarding fibronectin ED-B and CXCR4. Tumors that produce FAP have an ambivalent relationship with this protein. At first, they exploit FAP, but later they reduce its expressiveness. Although our study has not directly included FAP-Inhibitor (FAPI) PET/CT, the considerable expression of FAP reveals its potential as a diagnostic and therapeutic tool worthy of further investigation. This dynamic relationship between cancer and FAP has substantial diagnostic and therapeutic implications.

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Section: Methodsmentioning

confidence: 99%

Tumor Progression from a Fibroblast Activation Protein Perspective: Novel Diagnostic and Therapeutic Scenarios for Colorectal Cancer

Rossetti,

Stanca,

Del Frate

et al. 2023

Diagnostics

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Synchronous biliary gallstones and colorectal cancer: A single center analysis

Zarnescu

Dumitrascu

et al. 2021

Exp Ther Med

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Gallstones and colorectal cancer (CRC) are two common disorders that may develop simultaneously. In such situations, there is a significant chance of missing one of the conditions due to the primary clinical presentation. Late detection, diagnosis and treatment can be especially problematic in the case of unrecognized CRC. In the present study, the medical charts were retrospectively reviewed for all consecutive patients who were treated in the Second Department of Surgery, University Emergency Hospital Bucharest (Romania) between February 2015 and December 2017 following a diagnosis of CRC and/or biliary stones. There were 203 patients with CRC, 433 with biliary gallstones and 19 patients with both conditions. There were 125 men (61.6%) in the CRC group and 138 men (31.9%) in the gallstone group. The average age was 54.1±15.9 years in the gallstone group and 66.1±11.6 years in the CRC group. Obesity was observed in 96 patients (22.2%) with gallstones and in 14 (6.9%) patients in the CRC group. In the CRC group, 80 patients had medical comorbidities (39.4%), while in the gallstone group 126 patients (29.1%) had medical comorbidities. Bivariate analysis comparing gallstone only vs. gallstone and CRC identified age (P=0.001), male sex (P=0.001) and thyroid disease (P=0.001) as significant factors associated with synchronous diagnosis. The multivariable logistic regression of factors predicting CRC in patients with gallstones identified age (OR, 1.06; 95% CI, 1.023-1.105; P=0.002) and thyroid diseases (OR, 11.15; 95% CI, 2.532-49.06; P=0.001) as independent factors. There were significant differences regarding the location of the tumor between the CRC-only group and the gallstone and CRC group (P=0.001): Rectum (39.7 vs. 5.3%), left colon (26.6 vs. 21.1%), transverse colon (13 vs. 26.3%) and right colon (20.7 vs. 47.4%). The study concluded that, in patients with gallstones, age and thyroid conditions were significantly associated with CRC. Patients with a synchronous diagnosis of gallstones and CRC had significantly more right-sided CRC compared with regular CRC.

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The Metastatic Lymph Node Ratio is a Crucial Criterion in Colorectal Cancer Therapy Management and Prognosis

Kamali¹,

Kamali²

2022

eamr

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A Novel TNM Classification for Colorectal Cancers based on the Metro-ticket Paradigm

Cited by 3 publications

References 21 publications

Tumor Progression from a Fibroblast Activation Protein Perspective: Novel Diagnostic and Therapeutic Scenarios for Colorectal Cancer

Tumor Progression from a Fibroblast Activation Protein Perspective: Novel Diagnostic and Therapeutic Scenarios for Colorectal Cancer

Synchronous biliary gallstones and colorectal cancer: A single center analysis

The Metastatic Lymph Node Ratio is a Crucial Criterion in Colorectal Cancer Therapy Management and Prognosis

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