A novel TiZrNb medium entropy alloy (MEA) with appropriate elastic modulus for biocompatible materials

Hu, Shiwen; Li, Taojun; Su, Zhenqian; Meng, Shuaiju; Jia, Zhi; Liu, Dexue

doi:10.1016/j.mseb.2021.115226

Cited by 21 publications

(12 citation statements)

References 29 publications

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“…Let us now spend some time in discussing such literatures. Consistently with the predictions of C(x; 300K)/Q 0 (N spe ), all the members of the first group have been reported to grow as a single phase in either as-cast, homogenized or deposited conditions (46)(47)(48)(49)(50)(51). For instance, a comprehensive recent work from He et al (46) has shown that no phase transformation can be found for TiZrNb, Ti-HfNb, TiHfTa, TiZrHfNb and TiHfTaNb, even after a series of heat treatments, including firstly homogenization at 1150 • C for 24 hours, then heavily deformation by high-pressure torsion, and lastly annealing at various temperatures in the 750-1250 • C range.…”

Section: Dimensionless Entropy Descriptors To Catch the Heavy Entropy...supporting

confidence: 74%

Towards quantifying (meta-)stability of multi-principal element alloys: from configurational entropy to characteristic temperatures

Zhang,

Zhou,

Dong

et al. 2023

Preprint

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Understanding the thermodynamics of multi-principal-element alloys (MPEAs), although crucial for their design, remains an elusive task. The configurational entropy, Sconf, is a critical thermodynamic quantity determining stability, but its calculation for real materials poses a hard computational challenge. Strong of a highly efficient cluster expansion, constructed on density functional theory data,and of an advanced sampling technique, we are able to compute Sconf over the huge configurational and compositional space of the prototype bcc Ti-Zr-Hf-Nb-Ta system. In particular, we explore around 200,000 atomic arrangements across more than 200 compositions. The main features of the computed Sconf-vs-temperature curves can be captured by the definition of two characteristic temperatures, which are then used to define a dimensionless descriptor. This, together with Sconf, enable us to rank alloys according to their (meta- )stability across a broad composition range, going from equiatomic to nonequiatomic, and even to the regions covered by conventional alloys. Such classification is informed and validated against hundreds of experimental results. Our analysis allows us to revise the classification scheme of alloys into high-entropy, medium-entropy and low-entropy and, in general, sheds light into the thermodynamic origin of their metastability, ultimately helping in the design and development.

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Section: Dimensionless Entropy Descriptors To Catch the Heavy Entropy...supporting

confidence: 74%

Towards quantifying (meta-)stability of multi-principal element alloys: from configurational entropy to characteristic temperatures

Zhang,

Zhou,

Dong

et al. 2023

Preprint

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“…A high-priority goal in designing new metallic materials for load-bearing implant applications is to reduce Young’s modulus in the major loading direction approximating that of cortical bone. In recent years, some biological HEAs and MEAs have been developed ( Wang et al, 2017 ; Wang L. et al, 2018 ), and the elastic moduli of TiZrHf (HCP), TiZrNbHfTa (BCC), TiZrNbHf (BCC), and TiZrTaHf (BCC) alloys are 111, 103, 83, and 86GPa, respectively ( Hu et al, 2021 ). The elastic modulus of these alloys is relatively low, about half that of CoCr alloys and stainless steel, which is closer to human bone and can effectively reduce the effect of stress shielding.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…For Bio-HEAs with Ti and Ta elements, their lower E corr indicates that they will both readily form protective passivation layers (usually oxides) (Zheng et al, 2018). Most Bio-HEAs have no pitting reaction until 2V, which means promising applications in human environments around 0-0.2 V. No pitting and no localized corrosion due to the breakdown of the protective passivation films, dramatically increasing the lifetime of alloy implants (Hwang et al, 2019;Li T. et al, 2021). The corrosion current density indicates the corrosion rate of the material.…”

Section: Corrosion Resistancementioning

confidence: 99%

Bio-high entropy alloys: Progress, challenges, and opportunities

Feng

Tang

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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With the continuous progress and development in biomedicine, metallic biomedical materials have attracted significant attention from researchers. Due to the low compatibility of traditional metal implant materials with the human body, it is urgent to develop new biomaterials with excellent mechanical properties and appropriate biocompatibility to solve the adverse reactions caused by long-term implantation. High entropy alloys (HEAs) are nearly equimolar alloys of five or more elements, with huge compositional design space and excellent mechanical properties. In contrast, biological high-entropy alloys (Bio-HEAs) are expected to be a new bio-alloy for biomedicine due to their excellent biocompatibility and tunable mechanical properties. This review summarizes the composition system of Bio-HEAs in recent years, introduces their biocompatibility and mechanical properties of human bone adaptation, and finally puts forward the following suggestions for the development direction of Bio-HEAs: to improve the theory and simulation studies of Bio-HEAs composition design, to quantify the influence of composition, process, post-treatment on the performance of Bio-HEAs, to focus on the loss of Bio-HEAs under actual service conditions, and it is hoped that the clinical application of the new medical alloy Bio-HEAs can be realized as soon as possible.

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“…Figure 9a-c depict the relationships between the moduli and various thermodynamic parameters of published Bio-HEAs/MEAs [51,70,72,73,75,76,[78][79][80][81][82][83][84][85][86][87]. From Figure 9a, it can be seen that reducing the ∆S mix values of Bio-HEAs/MEAs effectively lowers the modulus, attributed to the design with non-equiatomic compositions resulting in a lower modulus (see "Section 4.2").…”

Section: Relationships Between Thermodynamic Parameters and Modulusmentioning

confidence: 97%

A Review: Design from Beta Titanium Alloys to Medium-Entropy Alloys for Biomedical Applications

Wong,

Hsu,

et al. 2023

Materials

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β-Ti alloys have long been investigated and applied in the biomedical field due to their exceptional mechanical properties, ductility, and corrosion resistance. Metastable β-Ti alloys have garnered interest in the realm of biomaterials owing to their notably low elastic modulus. Nevertheless, the inherent correlation between a low elastic modulus and relatively reduced strength persists, even in the case of metastable β-Ti alloys. Enhancing the strength of alloys contributes to improving their fatigue resistance, thereby preventing an implant material from failure in clinical usage. Recently, a series of biomedical high-entropy and medium-entropy alloys, composed of biocompatible elements such as Ti, Zr, Nb, Ta, and Mo, have been developed. Leveraging the contributions of the four core effects of high-entropy alloys, both biomedical high-entropy and medium-entropy alloys exhibit excellent mechanical strength, corrosion resistance, and biocompatibility, albeit accompanied by an elevated elastic modulus. To satisfy the demands of biomedical implants, researchers have sought to synthesize the strengths of high-entropy alloys and metastable β-Ti alloys, culminating in the development of metastable high-entropy/medium-entropy alloys that manifest both high strength and a low elastic modulus. Consequently, the design principles for new-generation biomedical medium-entropy alloys and conventional metastable β-Ti alloys can be converged. This review focuses on the design from β-Ti alloys to the novel metastable medium-entropy alloys for biomedical applications.

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A novel TiZrNb medium entropy alloy (MEA) with appropriate elastic modulus for biocompatible materials

Cited by 21 publications

References 29 publications

Towards quantifying (meta-)stability of multi-principal element alloys: from configurational entropy to characteristic temperatures

Towards quantifying (meta-)stability of multi-principal element alloys: from configurational entropy to characteristic temperatures

Bio-high entropy alloys: Progress, challenges, and opportunities

A Review: Design from Beta Titanium Alloys to Medium-Entropy Alloys for Biomedical Applications

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