A Novel Three‐Component Reaction for the Diastereoselective Synthesis of 2H‐Pyrimido[2,1‐a]isoquinolines via 1,4‐Dipolar Cycloaddition.

Nair, Vijay; Sreekanth, A. R.; Abhilash, N.; Bhadbhade, Mohan; Gonnade, Rajesh

doi:10.1002/chin.200310159

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Studies With Isoquinoline As the Nucleophile1

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2003

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“…40 Analogous three-component condensation of isoquinoline, DMAD, and N-tosylimine resulted in the diastereoselective synthesis of 2H-pyrimido[2,1-a]isoquinoline derivatives in good yields (Scheme 30). 41…”

Section: Studies With Isoquinoline As the Nucleophilementioning

confidence: 99%

Strategies for Heterocyclic Construction via Novel Multicomponent Reactions Based on Isocyanides and Nucleophilic Carbenes

et al. 2003

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This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.

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Section: Studies With Isoquinoline As the Nucleophilementioning

confidence: 99%