A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux

Guo, Haiyun; Wei, Dongmei; Li, Rui; Zhang, Chao; Jiang, Song; Wang, Weijia; Hu, Hongzhe; Shen, Lijuan; Liang, Xiaofei

doi:10.1007/s13105-021-00870-5

Cited by 8 publications

(2 citation statements)

References 111 publications

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“…Studies have shown that autophagy can regulate cholesterol efflux from macrophages and prevent the formation of FCs. [ 35 ] Furthermore, a recent study has demonstrated that a modest elevation in macrophage autophagy could lead to a reduction in intracellular lipid accumulation and the suppression of oxidative stress responses, which contributes to the stability of vulnerable plaques in AS. [ 36 ] Beclin‐1, LC3 and p62 are important proteins that are involved in autophagy.…”

Section: Resultsmentioning

confidence: 99%

Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability

Lv,

Fang,

Huang

et al. 2024

Advanced Science

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Atherosclerotic cardiovascular disease (ASCVD) has become the leading cause of death worldwide, and early diagnosis and treatment of atherosclerosis (AS) are crucial for reducing the occurrence of acute cardiovascular events. However, early diagnosis of AS is challenging, and oral anti‐AS drugs suffer from limitations like imprecise targeting and low bioavailability. To overcome the aforementioned shortcomings, Cur/MOF@DS is developed, a nanoplatform integrating diagnosis and treatment by loading curcumin (Cur) into metal−organic frameworks with nanozymes and magnetic resonance imaging (MRI) properties. In addition, the surface‐modification of dextran sulfate (DS) enables PCN‐222(Mn) effectively target scavenger receptor class A in macrophages or foam cells within the plaque region. This nanoplatform employs mechanisms that effectively scavenge excessive reactive oxygen species in the plaque microenvironment, promote macrophage autophagy and regulate macrophage polarization to realize lipid regulation. In vivo and in vitro experiments confirm that this nanoplatform has outstanding MRI performance and anti‐AS effects, which may provide a new option for early diagnosis and treatment of AS.

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Section: Resultsmentioning

confidence: 99%

Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability

Lv,

Fang,

Huang

et al. 2024

Advanced Science

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“…Besides the direct effect of photodynamic therapy on proliferating cells, in vitro , it was observed that silica upconversion nanoparticles encapsulating photosensitiser chlorin e6 (Ce6) in combination with a 980 nm laser also increased ABCA1-mediated cholesterol efflux in THP-1-derived foam cells. This effect was probably mediated by the induction of autophagy through the ROS/PI3K/Akt/mTOR signalling pathway [ 608 , 609 ]. A positive effect of different formulas of Ce6 photosensitiser on atheroma plaques, which may be partially explained by increased cholesterol efflux, was observed also in vivo in mice [ 610 ] and rabbits [ 611 ].…”

Section: Currently Available Hdl-targeted Therapiesmentioning

confidence: 99%

Alterations of HDL’s to piHDL’s Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies

2022

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Chronic inflammatory diseases, such as rheumatoid arthritis, steatohepatitis, periodontitis, chronic kidney disease, and others are associated with an increased risk of atherosclerotic cardiovascular disease, which persists even after accounting for traditional cardiac risk factors. The common factor linking these diseases to accelerated atherosclerosis is chronic systemic low-grade inflammation triggering changes in lipoprotein structure and metabolism. HDL, an independent marker of cardiovascular risk, is a lipoprotein particle with numerous important anti-atherogenic properties. Besides the essential role in reverse cholesterol transport, HDL possesses antioxidative, anti-inflammatory, antiapoptotic, and antithrombotic properties. Inflammation and inflammation-associated pathologies can cause modifications in HDL’s proteome and lipidome, transforming HDL from atheroprotective into a pro-atherosclerotic lipoprotein. Therefore, a simple increase in HDL concentration in patients with inflammatory diseases has not led to the desired anti-atherogenic outcome. In this review, the functions of individual protein components of HDL, rendering them either anti-inflammatory or pro-inflammatory are described in detail. Alterations of HDL proteome (such as replacing atheroprotective proteins by pro-inflammatory proteins, or posttranslational modifications) in patients with chronic inflammatory diseases and their impact on cardiovascular health are discussed. Finally, molecular, and clinical aspects of HDL-targeted therapies, including those used in therapeutical practice, drugs in clinical trials, and experimental drugs are comprehensively summarised.

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Blocking H1R signal aggravates atherosclerosis by promoting inflammation and foam cell formation

Zhu,

Yang,

Wang

et al. 2024

J Mol Med

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A novel therapeutic strategy for atherosclerosis: autophagy-dependent cholesterol efflux

Cited by 8 publications

References 111 publications

Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability

Curcumin Equipped Nanozyme‐Like Metal−Organic Framework Platform for the Targeted Atherosclerosis Treatment with Lipid Regulation and Enhanced Magnetic Resonance Imaging Capability

Alterations of HDL’s to piHDL’s Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies

Blocking H1R signal aggravates atherosclerosis by promoting inflammation and foam cell formation

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