2022
DOI: 10.1016/j.bbamcr.2022.119263
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A novel therapeutic combination of sitagliptin and melatonin regenerates pancreatic β-cells in mouse and human islets

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Cited by 11 publications
(15 citation statements)
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“…In a preclinical study of the effects of melatonin alone or combined with the dipeptidyl peptidase IV, sitagliptin, combination therapy induced mouse pancreatic β-cell regeneration under glucotoxic stress, which was replicated in the human islet transplant mouse model. Combination therapy also induced pancreatic β-cell proliferation, reduced fasting blood glucose levels, and enhanced plasma insulin levels and glucose tolerance [ 109 ]. When used alone, melatonin reduced pancreatic β-cell apoptosis [ 109 ].…”
Section: Melatonergic Pathway and T1dmmentioning
confidence: 99%
See 1 more Smart Citation
“…In a preclinical study of the effects of melatonin alone or combined with the dipeptidyl peptidase IV, sitagliptin, combination therapy induced mouse pancreatic β-cell regeneration under glucotoxic stress, which was replicated in the human islet transplant mouse model. Combination therapy also induced pancreatic β-cell proliferation, reduced fasting blood glucose levels, and enhanced plasma insulin levels and glucose tolerance [ 109 ]. When used alone, melatonin reduced pancreatic β-cell apoptosis [ 109 ].…”
Section: Melatonergic Pathway and T1dmmentioning
confidence: 99%
“…Combination therapy also induced pancreatic β-cell proliferation, reduced fasting blood glucose levels, and enhanced plasma insulin levels and glucose tolerance [ 109 ]. When used alone, melatonin reduced pancreatic β-cell apoptosis [ 109 ]. Melatonin also prevents kidney disorders, bone loss, retinal dysfunction, and cognitive dysfunction evident in streptozotocin-induced T1DM in preclinical models [ 110 ].…”
Section: Melatonergic Pathway and T1dmmentioning
confidence: 99%
“…After 21-days of GC flattening, mice were sacrificed, and the pancreas was harvested. To study b-cell proliferation [Insulin/Ki67], immunofluorescence staining was carried out as previously described (Patel et al, 2022). Briefly, the pancreas was fixed in 4% paraformaldehyde for histological processing and paraffin embedding.…”
Section: Immunohistochemistrymentioning
confidence: 99%
“…Interestingly, many recent studies have investigated the antioxidant and anti-inflammatory effects of these inhibitors. 6 - 13 …”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, many recent studies have investigated the antioxidant and antiinflammatory effects of these inhibitors. [6][7][8][9][10][11][12][13] Further, many antioxidants, anti-inflammatory, and antiinfective bioactive compounds have been studied to be effective biocontrols against animal and human diseases including zoonotic conditions of intestine. 3,[14][15][16][17][18] Nevertheless, antioxidants are mostly present in fruits and vegetable and possess great potential against oxidative damage.…”
Section: Introductionmentioning
confidence: 99%