A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality via Regulating Brain Electrochemical Activity

Dasdelen, Muhammed Furkan; Er, Sezgin; Kaplan, Berkan; Çelik, Süleyman Utku; Beker, Mustafa Çağlar; Orhan, Cemal; Tuzcu, Mehmet; Şahin, Nurhan; Mamedova, Havakhanum; Sylla, Sarah; Komorowski, James; Ojalvo, Sara Perez; Şahin, Kazım; Kılıç, Ertuğrul

doi:10.3389/fnut.2022.874254

Cited by 7 publications

(6 citation statements)

References 60 publications

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“…Conversely, both 100 and 300 mg/kg doses of VA increased the serotonin, dopamine, and melatonin levels in serum compared to the caffeine group. Similarly to these results, our earlier study showed that L-theanine could affect accordingly in terms of these hormone level changes [26].…”

Section: Discussionsupporting

confidence: 84%

“…Caffeine, at a dose of 7.5 mg/kg administered through intraperitoneal injection, serves as a sleep disruption agent in mice [ 26 ]. The impact of caffeine on brain function is tracked using electrocorticography (ECoG).…”

Section: Methodsmentioning

confidence: 99%

“…Following the protocols established in previous research [ 26 ], brain tissue samples were collected for analyzing GABAergic receptors GABAA R2 (Cat. No.…”

Section: Methodsmentioning

confidence: 99%

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Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model

Sahin,

Gencoglu,

Korkusuz

et al. 2024

Antioxidants

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Insomnia is a major global health issue, highlighting the need for treatments that are both effective and safe. Valerian extract, a traditional remedy for sleep problems, offers potential therapeutic options. This research examined the potential sleep-enhancing effects of VA (Valerian Pdr%2) in mice. The study evaluated sleep quality by comparing the impact of the VA extract against melatonin on brain activity, using electrocorticography (ECoG) to assess changes in brain waves. For this purpose, the study utilized two experimental models on BALB/c mice to explore the effects of caffeine-induced insomnia and pentobarbital-induced sleep. In the first model, 25 mice were assigned to five groups to test the effects of caffeine (caffeine, 7.5 mg/kg i.p) alone, caffeine with melatonin (2 mg/kg), or caffeine with different doses of valerian extract (100 or 300 mg/kg) given orally on brain activity, assessed via electrocorticography (ECoG) and further analyses on the receptor proteins and neurotransmitters. In the second model, a different set of 25 mice were divided into five groups to examine the impact of pentobarbital (42 mg/kg) alone, with melatonin, or with the valerian extract on sleep induction, observing the effects 45 min after administration. The study found that ECoG frequencies were lower in groups treated with melatonin and two doses of valerian extract (100 and 300 mg/kg), with 300 mg/kg showing the most significant effect in reducing frequencies compared to the caffeine control group, indicating enhanced sleep quality (p < 0.05). This was supported by increased levels of serotonin, melatonin, and dopamine and higher levels of certain brain receptors in the melatonin and valerian extract groups (p < 0.05). Modulatory efficacy for the apoptotic markers in the brain was also noted (p < 0.05). Additionally, melatonin and both doses of VA increased sleep duration and reduced sleep onset time compared to the pentobarbital control, which was particularly notable with high doses. In conclusion, the findings suggest that high doses (300 mg/kg) of valerian extract enhance both the quantity and quality of sleep through the GABAergic pathway and effectively increase sleep duration while reducing the time to fall asleep in a pentobarbital-induced sleep model in mice.

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Section: Discussionsupporting

confidence: 84%

Section: Methodsmentioning

confidence: 99%

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Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model

Sahin,

Gencoglu,

Korkusuz

et al. 2024

Antioxidants

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“…Therefore, L-theanine can be advised to ameliorate sleep duration in individuals consuming excessive amounts of coffeine. A study performed on animals by Dasdelen et al (2022) depicted L-theanine as well as Mg-Ltheanine (a novel complex of L-theanine with magnesium) induced slow-brain waves, regulated brain electrical activity and increased GABA neurotransmitter and receptor level. It was concluded that L-theanine reverses the impact of caffeine on sleep disturbance [30].…”

Section: Sleep Disordersmentioning

confidence: 99%

The application of L-theanine for patients with mental health conditions - a review

Łata,

Getka,

Kwiecień

et al. 2024

J Educ Health Sport

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L-theanine is an amino-acid found in green tea (Camellia sinensis), a beverage consumed by people all around the world. Its chemical structure is similar to L-glutamic acid. L-theanine acts as an antagonist of AMPA and kainate receptors as well as partial co-agonist of the NMDA receptors. The application may be associated with several health benefits, such as improvements in cognition, reduction of stress and anxiety-like symptoms. Although the dosage of L-theanine in green tea, which is around 20 mg per tea, is not very likely to have meaningful impact on mental health, supplementation of doses 200-400 mg/day has shown some promising advantages.Despite some evidence towards beneficial impact of L-theanine on mental health, longer-term and larger cohort clinical studies are required in order to justify its application for patients suffering from such diseases as anxiety, depression, bipolar disorder, schizophrenia and sleep disorders. What is more, it is more possible to act as a therapy augmentation in particular cases, rather than conventional therapy replacement.

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“…L-theanine also acts as a relaxant by increasing GABA release, which in turn increases dopamine expression in the brain [13]. Widely used for sleep disorders and stress mitigation, L-theanine is able to counteract caffeine with its calming effect [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress (CUMS) in mice

Yu,

Zhu,

Jiang

et al. 2024

Food Science and Human Wellness

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Depression is a prevalent mental disorder with limited effective treatments, posing a significant global issue. This study explored L-theanine and geniposide, key components in "food-medicine homology" materials, to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6J mice were divided into control, CUMS model, and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors, including reduced activity and sucrose preference. TG treatment partially reversed these changes, significantly increasing antioxidant enzyme activities, decreasing pro-inflammatory cytokine levels, and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene, upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group, including increased Firmicutes, reduced Bacteroidetes and Prevotella, and variable changes in Bifidobacterium abundance. In conclusion, our study indicates that CUMS exposure upregulates stress hormones and TTR expression, associated with neuroinflammation, oxidative stress, monoamine depletion, depression-like behaviors, and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota, suggesting L-theanine and geniposide's potential as a novel depression therapy.

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A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality via Regulating Brain Electrochemical Activity

Cited by 7 publications

References 60 publications

Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model

Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model

The application of L-theanine for patients with mental health conditions - a review

Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress (CUMS) in mice

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