A novel technique using spectral-domain optical coherence tomography (Spectralis, SD-OCT+HRA) to image supine non-anaesthetized infants: utility demonstrated in aggressive posterior retinopathy of prematurity

Vinekar, Anand; Sivakumar, Muthusamy; Shetty, Rohit; Mahendradas, Padmamalini; Krishnan, Narasimha; Mallipatna, Ashwin; Shetty, K Bhujang

doi:10.1038/eye.2009.313

Cited by 50 publications

(31 citation statements)

References 6 publications

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“…Furthermore, previous studies reporting the SD-OCT findings of premature infants did not document this phenomenon. [4][5][6][7][8][9][10]21 Infants with bilateral subretinal fluid did not significantly differ from infants without bilateral subretinal fluid in the prevalence of persistent inner retinal layers at the foveal center, an important sign of premature retinal development [26][27][28] .…”

Section: Discussionmentioning

confidence: 99%

“…1 Hand-held OCT is well tolerated by children and infants, and is more sensitive than clinical examination in detecting macular pathology. 2,3 OCT has been used to identify clinically important retinal pathologies in premature infants, including retinoschisis, [4][5][6] foveal hypoplasia, 6,7 intraretinal cysts, 6,8 preretinal neovascularization, 5,9 and retinal detachment. 5,10 Macular holes, 11 hemorrhagic retinoschisis, 12,13 vitreoretinal traction and epiretinal membranes 11,12 were identified in Shaken Baby Syndrome using OCT, and in some cases influenced surgical management.…”

Section: Introductionmentioning

confidence: 99%

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Subfoveal fluid in healthy full-term newborns observed by handheld spectral domain optical coherence tomography

Cabrera¹,

O’Connell²,

Toth³

et al. 2012

Journal of American Association for Pediatric Ophthalmology and

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Purpose-To report retinal findings for healthy newborn infants imaged with hand held Spectral Domain Optical Coherence Tomography (SD-OCT). Design-Prospective observational case series.Methods-Thirty-nine full term newborn infants had dilated retinal examinations by indirect ophthalmoscopy and retinal imaging by handheld SD-OCT, without sedation, at the Duke Birthing Center.Results-Of the 39 infants imaged, 44% (17/39) were male. Race/ethnicity composition was 56% white, 38% black, 3% Asian, and 3% Hispanic. Median gestational age was 39 weeks (range 36 to 41). Six of the 39 infants (15%) had bilateral subfoveal fluid on SD-OCT not seen by indirect ophthalmoscopy. Eight infants (21%) had retinal hemorrhages noted on dilated retinal examination, 1 of which had subretinal fluid on SD-OCT. Subretinal fluid was noted on follow up examination to have resolved on SD-OCT 1 to 4 months later. Infants with bilateral subretinal fluid had an older gestational age compared to infants without subretinal fluid (median 40.4 vs. 39.1 weeks, respectively, P=0.03) and were more likely to have had mothers with diabetes (2/6 vs. 0/33, respectively, P=0.02). Vaginal versus C-section delivery was not significantly different between the two groups.Conclusions-Some healthy full term infants have bilateral subfoveal fluid not obvious on dilated retinal examination. This fluid resolves within several months. The visual significance of this finding is unknown, but clinicians should be aware it is common when evaluating newborn infants for retinal pathology using SD-OCT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Subfoveal fluid in healthy full-term newborns observed by handheld spectral domain optical coherence tomography

Cabrera¹,

O’Connell²,

Toth³

et al. 2012

Journal of American Association for Pediatric Ophthalmology and

View full text Add to dashboard Cite

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“…In the future, the use of a hand-held anterior segment SD-OCT will be of great help during performing anterior segment surgeries including pterygium excision through giving a real-time in vivo imaging to ensure total removal of this lesion (Maldonado et al 2010;Vinekar et al 2010). .…”

Section: Discussionmentioning

confidence: 99%

Spectral domain anterior segment optical coherence tomography assessment of pterygium and pinguecula

Soliman

Mohamed

2010

Acta Ophthalmologica

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ABSTRACT.Purpose: To study the morphological patterns of pterygia and pingueculae using high-resolution anterior segment spectral domain optical coherence tomography (SD-OCT). Methods: Prospective cross-sectional study of 25 eyes presented with pterygia and pingueculae was conducted, and the eyes were examined by anterior segment SD-OCT. Results: We examined 25 eyes, including 13 eyes with primary pterygia, six eyes with recurrent pterygia, one case with a pseudopterygium and five eyes with pingueculae. Primary pterygia revealed elevation of the corneal epithelium by a wedge-shaped mass of tissue separating the corneal epithelium from the underlying Bowman's membrane, which became wavy and interrupted. We found satellite masses of pterygium tissue advanced under the epithelium beyond the clinically seen pterygium margins. In recurrent pterygia, we detected that the central tip of the pterygium was more advanced and creeping beneath the basal corneal epithelium than the primary pterygium. In pseudopterygium, the SD-OCT images showed that the overgrowing membrane was not really attached to the underlying cornea. In cases of pingueculae, SD-OCT revealed a wedge-shaped mass that was nearly similar in pattern to that of the pterygia but stopped at the limbal region. Immediately after removal of pterygia, we noticed many remnants of the pterygia masses over the corneal stroma in spite of the clinically clear appearance of cornea. Conclusions: SD-OCT provided us with high-resolution images of the pterygium and the pinguecula and showed clearly the anatomical relationship between the corneal tissues and these lesions. The use of this new modality of imaging may help to decrease the current recurrence rates after pterygium excision through using the anterior segment SD-OCT in the evaluation of these lesions.

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“…In early stages, AP-ROP is characterized by the presence of plus disease out of proportion to the perceived severity of disease at the vascular-avascular border. However, close observation, spectral domain optical coherence tomography [29], or wide-field fluorescein angiography will reveal the presence of often broad areas of neovascularization anterior to the termination of illdefined immature intrinsic retinal vascularization, growing flatly just above and parallel to the retinal surface (FIGURE 1). This is in contrast to classic ROP in which neovascularization originates from the posterior margin of a well-defined ridge and grows anteriorly off the retinal surface toward the mid-vitreous cavity and can occur in any zone.…”

Section: Aggressive Posterior Retinopathy Of Prematuritymentioning

confidence: 98%

Review of the latest treatments for retinopathy of prematurity: laser photo-ablation versus intravitreal anti-VEGF agents in the management of high-risk pre-threshold (type 1) disease

Robinson

Capone

2015

Expert Review of Ophthalmology

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A novel technique using spectral-domain optical coherence tomography (Spectralis, SD-OCT+HRA) to image supine non-anaesthetized infants: utility demonstrated in aggressive posterior retinopathy of prematurity

Cited by 50 publications

References 6 publications

Subfoveal fluid in healthy full-term newborns observed by handheld spectral domain optical coherence tomography

Subfoveal fluid in healthy full-term newborns observed by handheld spectral domain optical coherence tomography

Spectral domain anterior segment optical coherence tomography assessment of pterygium and pinguecula

Review of the latest treatments for retinopathy of prematurity: laser photo-ablation versus intravitreal anti-VEGF agents in the management of high-risk pre-threshold (type 1) disease

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