A novel technique to apply a Seprafilm (hyaluronate–carboxymethylcellulose) barrier following laparoscopic surgeries

Chuang, Yung Chun; Fan, Chun-Nan; Cho, Fu-Nan; Kan, Yuan-Yee; Chang, Yu-Hsiang; Kang, Hong-Yo

doi:10.1016/j.fertnstert.2007.10.003

Cited by 45 publications

(31 citation statements)

References 10 publications

(10 reference statements)

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“…Some authors have reported that HA/CMC is difficult to use under moist conditions as it is vulnerable to tearing and undesired sticking [11,12,13,14]. An antiadhesive membrane that is resistant to tearing under moist conditions and does not stick to moist surfaces during movement to the target organ would thus be easier to use.…”

Section: Discussionmentioning

confidence: 99%

“…However, HA/CMC is difficult to apply in the moist environment of intra-abdominal organs [11,12] as it is vulnerable to tears and to sticking to wounds in the abdominal wall or gloves, in addition to target organs [13]. Takeuchi et al [14 ]reported that up to 20% of this agent was discarded during a laparoscopic abdominal procedure owing to handling difficulties.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Novel, Nearly Insoluble Antiadhesive Membrane

Mukai

Kamitani²,

Shimizu³

et al. 2011

Eur Surg Res

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Background: Sodium hyaluronate/carboxymethylcellulose (HA/CMC) is difficult to use in a moist environment because of its susceptibility to moisture. Methods: We developed the three-layered nDM-14R membrane. The surface layers are composed of 1-lactide, glycolide and e-caprolactone copolymers. HA/CMC and nDM-14R were used in all these studies. (1) The central region of 1 × 10 cm specimens (n = 5) was moistened for 0, 5, 10, 20, 30 or 60 s, after which the tensile strength was determined; (2) one side of specimens of 1 × 10 cm (n = 5) was moistened with agar gel for 5, 10, 15 or 30 s, after which the adhesion strength was determined, and (3) Rat cecum (n = 10) was scratched, 3 × 3 cm specimens were placed on the scratched area, and adhesions were evaluated on postoperative day 14. Results and Conclusion: (1) The tensile strength of nDM-14R after contact for 10–30 s was greater than that of HA/CMC. (2) The adhesive strength of HA/CMC after contact for 5–10 s was greater than that of nDM-14R. (3) Adhesion scores in treatment groups were significantly lower than in the control group. The results suggest that nDM-14R has the same antiadhesive effect and allows easier placement under moist conditions than HA/CMC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a Novel, Nearly Insoluble Antiadhesive Membrane

Mukai

Kamitani²,

Shimizu³

et al. 2011

Eur Surg Res

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“…Presumably, such product is partially derivatized, partially crosslinked (Young et al, 2004). It is indicated for use in patients undergoing abdominal or pelvical laparotomy to reduce the incidence, the extent and the severity of postoperative adhesions (Chuang et al, 2008). A similar application is proposed for Incert by Anika Therapeutics, Inc. (Woburn, MA) (Haney & Doty, 1998) (table 5).…”

Section: Crosslinked Ha Applicationsmentioning

confidence: 99%

Biotechnological Production and Application of Hyaluronan

Schiraldi¹,

Gatta²,

Rosa³

2010

Biopolymers

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“…Several techniques for laparoscopic placement of Seprafilm have been reported [4,5]. However, those methods are not easy-to-use approaches and, in reality, are not widely used.…”

Section: Discussionmentioning

confidence: 99%

Simple and Easy Technique for the Placement of Seprafilm During Laparoscopic Surgery

et al. 2015

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Laparoscopic surgery is a minimally invasive surgery, and the incidence of postoperative small bowel obstruction (SBO) is not high. However, SBO is a disease that detracts from the benefits of laparoscopic surgery due to the need for additional therapies or prolongation of hospital stay. Seprafilm is effective in reducing adhesions and preventing the occurrence of SBO. However, it is very difficult to place the Seprafilm during laparoscopic surgery compared to open surgery. Herein, we report a simple and easy method. The Seprafilm including the holder paper is divided into six pieces; each piece is wound around the end of the forceps and the reduction sleeve is slid over it. The forceps with the reduction sleeve is inserted through a 12-mm trocar and moved closer to the target place. Then, the reduction sleeve is slid down the forceps to expose the Seprafilm. This method does not require any special preparation or training. Based on our experience, this method can easily overcome the problems that the Seprafilm is vulnerable to tear and is difficult to spread out in the abdominal cavity.

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A novel technique to apply a Seprafilm (hyaluronate–carboxymethylcellulose) barrier following laparoscopic surgeries

Cited by 45 publications

References 10 publications

Development of a Novel, Nearly Insoluble Antiadhesive Membrane

Development of a Novel, Nearly Insoluble Antiadhesive Membrane

Biotechnological Production and Application of Hyaluronan

Simple and Easy Technique for the Placement of Seprafilm During Laparoscopic Surgery

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