A novel technique of detecting<scp>MRI</scp>‐negative lesion in focal symptomatic epilepsy: Intraoperative<scp>S</scp>hear<scp>W</scp>ave<scp>E</scp>lastography

Chan, Huan Wee; Pressler, Ronit; Uff, Chris; Gunny, R; Piers, Kelly St; Cross, Helen; Bamber, Jeffrey C.; Dorward, Neil; Harkness, William; Chakraborty, Aabir

doi:10.1111/epi.12562

Cited by 44 publications

(34 citation statements)

References 14 publications

(16 reference statements)

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“…Using SWE, Chan et al (2014) revealed a focal area of increased stiffness approximately 1.5 cm from the brain surface (Fig. 1E) on a 7 year old boy presented with a 5 year history of medication-resistant frontal lobe epilepsy.…”

Section: Ex Vivo Brainmentioning

confidence: 99%

Biomechanical characterization of ex vivo human brain using ultrasound shear wave spectroscopy

et al. 2018

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The characterization of brain tissue is crucial to better understand neurological disorders. Mechanical characterization is an emerging tool in that field. The purpose of this work was to validate a transient ultrasound technique aimed at measuring dispersion of mechanical parameters of the brain tissue. The first part of this work was dedicated to the validation of that technique by comparing it with two proven rheology methods: a rotating plate rheometer, and a viscoelastic spectroscopy apparatus. Experiments were done on tissue mimicking gels. Results were compared on storage and loss modulus in the 20-100 Hz band. Our method was validated for the measurement of storage modulus dispersion, with some reserves on the measurement of loss modulus. The second part of this work was the measurement of the mechanical characteristics of ex vivo human white matter. We were able to measure the dispersion of the storage and loss modulus in the 20-100 Hz band, fitting the data with a custom power law model.

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Section: Ex Vivo Brainmentioning

confidence: 99%

Biomechanical characterization of ex vivo human brain using ultrasound shear wave spectroscopy

et al. 2018

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“…7,32 In addition to traditional intraoperative CT and MRI, further technologies such as advanced intraoperative ultrasonography and intraoperative elasticity imaging may better aid in real-time identification of dysplastic lesions and in more accurate depiction of margins. 5,18 Furthermore, intraoperative ultrasonography has been shown to successfully integrate with functional MRI and DTI to provide an intraoperative update to neuronavigation accounting for brain shift. 26 While we found iMRI to be a powerful addition to preexisting epilepsy protocol techniques, its resolution is limited to approximately 1 mm.…”

Section: Discussionmentioning

confidence: 99%

The role of intraoperative MRI in resective epilepsy surgery for peri-eloquent cortex cortical dysplasias and heterotopias in pediatric patients

Sacino¹,

Murnick

et al. 2016

FOC

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OBJECTIVE Previous studies have demonstrated that an important factor in seizure freedom following surgery for lesional epilepsy in the peri-eloquent cortex is completeness of resection. However, aggressive resection of epileptic tissue localized to this region must be balanced with the competing objective of retaining postoperative neurological functioning. The objective of this study was to investigate the role of intraoperative MRI (iMRI) as a complement to existing epilepsy protocol techniques and to compare rates of seizure freedom and neurological deficit in pediatric patients undergoing resection of perieloquent lesions. METHODS The authors retrospectively reviewed the medical records of pediatric patients who underwent resection of focal cortical dysplasia (FCD) or heterotopia localized to eloquent cortex regions at the Children's National Health System between March 2005 and August 2015. Patients were grouped into two categories depending on whether they underwent conventional resection (n = 18) or iMRI-assisted resection (n = 11). Patient records were reviewed for factors including demographics, length of hospitalization, postoperative seizure freedom, postoperative neurological deficit, and need for reoperation. Postsurgical seizure outcome was assessed at the last postoperative follow-up evaluation using the Engel Epilepsy Surgery Outcome Scale. RESULTS At the time of the last postoperative follow-up examination, 9 (82%) of the 11 patients in the iMRI resection group were seizure free (Engel Class I), compared with 7 (39%) of the 18 patients in the control resection group (p = 0.05). Ten (91%) of the 11 patients in the iMRI cohort achieved gross-total resection (GTR), compared with 8 (44%) of 18 patients in the conventional resection cohort (p = 0.02). One patient in the iMRI-assisted resection group underwent successful reoperation at a later date for residual dysplasia, compared with 7 patients in the conventional resection cohort (with 2/7 achieving complete resection). Four (36%) of the patients in the iMRI cohort developed postoperative neurological deficits, compared with 15 patients (83%) in the conventional resection cohort (p = 0.02). CONCLUSIONS These results suggest that in comparison with a conventional surgical protocol and technique for resection of epileptic lesions in peri-eloquent cortex, the incorporation of iMRI led to elevated rates of GTR and postoperative seizure freedom. Furthermore, this study suggests that iMRI-assisted surgeries are associated with a reduction in neurological deficits due to intraoperative damage of eloquent cortex.

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“…The adult thyroid has been extensively examined by US techniques [9,[67][68][69][70][71][72] but little is known for the use of US elastography in pediatric patients [73].…”

Section: Spleenmentioning

confidence: 99%

General advice in ultrasound based elastography of pediatric patients

et al. 2019

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Ultrasound elastography including transient elastography (TE), point shear wave elastography, (pSWE) and two (three)- dimensional shear wave elastography (2D-SWE) have been introduced mainly for the evaluation of the liver. All the techniques are also feasible for the examination of spleen, whereas pSWE and 2D-SWE can be used for the assessment of the pancreas, kidney, gastrointestinal tract and other organs. Strain elastography also plays a role for non-liver applications. The aim of the current report is to highlight unique features and techniques for the elastographic examinations in children and to report initial results in non-liver applications

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A novel technique of detectingMRI‐negative lesion in focal symptomatic epilepsy: IntraoperativeShearWaveElastography

Cited by 44 publications

References 14 publications

Biomechanical characterization of ex vivo human brain using ultrasound shear wave spectroscopy

Biomechanical characterization of ex vivo human brain using ultrasound shear wave spectroscopy

The role of intraoperative MRI in resective epilepsy surgery for peri-eloquent cortex cortical dysplasias and heterotopias in pediatric patients

General advice in ultrasound based elastography of pediatric patients

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