A Novel Synthetic Approach Towards 2‐Guanidinomethyl‐4(5)‐sulfamoylimidazoles.

Abstract

A Novel Synthetic Approach Towards 2-Guanidinomethyl-4(5)-sulfamoylimidazoles. -Key step to the preparation of title compounds (VII) is the controlled lithiation of the 2-guanidinomethylimidazole (IV). Thus, blockage of the methylene carbon with Tms allows the selective formation of a trianion and regioselective introduction of sulfur electrophiles. -(PRICE*, S.; BULL, R.; CRAMP, S.; GARDAN, S.; VAN DEN HEUVEL, M.; NEIGHBOUR, D.; OSBOURN, S. E.; DE ESCH, I. J. P.; BUENEMANN, C. L.; Tetrahedron Lett. 45 (2004) 29, 5581-5583; Argenta Discovery Ltd., Harlow, Essex CM19 5TR, UK; Eng.) -Mais 44-133