A Novel Synthesis of Fluorine‐Containing Quaternary Amino Acid Derivatives via Palladium‐Catalyzed Allylation Reaction.

Abstract

A Novel Synthesis of Fluorine-Containing Quaternary Amino Acid Derivatives via Palladium-Catalyzed Allylation Reaction. -Optimal reaction conditions for the selective C-monoallylation reaction of protected amino acids (I) are found. Derivative (IIId) is used as starting compound in the synthesis of α-trifluoromethylleucine (V). -(KONNO*, T.; KANDA, M.; ISHIHARA, T.; YAMANAKA, H.; J. Fluorine Chem. 126 (2005) 11-12, 1517-1523; Dep. Chem. Mater. Technol., Kyoto Inst. Technol., Sakyo, Kyoto 606, Japan; Eng.) -R. Staver 14-195