A novel synthesis of flourinated pyrido [2,3-d] pyrimidine derivatives

Synthesis and herbicidal activities of fluorine-containing 3-pyridylmethyl-2-phenyliminothiazolidine derivatives

“…Base on the insight of synthesis of aryl isothiocyanates [20][21][22][23][24], aryl isothiocyanates with strong electron-withdrawing fluorine were prepared by a more straightforward and convenient synthetic route in one step and good yield (Scheme 1). Reaction of fluorophenyl amines with carbon disulfide in the presence of triethylamine gave triethylammonium dithiocarbamate salts.…”

Syntheses, structures and bioactivities of fluorine-containing phenylimino-thia(oxa)zolidine derivatives as agricultural bioregulators

“…Aryl isothiocyanates, which were frequently used for the preparation of medicine or pesticides, are usually synthesized from arylamines through treatment with carbon disulfide, aqueous ammonia and lead nitrate [26] or by treatment with thiophosgene [27], the other synthetic methods were from monoarylthioureas [27], phosphoramidates [28], aryliminodithiazoles [29] or amine (modified Kaluza method) [30]. However, the most of these methods are laborious and suffer from low yields, and its very difficult for us to follow the known synthetic methods for synthesis of fluoroaryl isothiocyanates, as the presence of too strong electronwithdrawing fluorine.…”

New pyridinecarbonitriles from fluoro arylpropenones

“…for C,,,H,,F,N,O (336.344): C 71.42,H 4.20,N 8.33;found: C 71.45,H 4.11,N 8.50%. 'H NMR (CDCI,): 6 1.5 ppm (t, 3H, ethoxy CH,, J 7 Hz); 4.66 (9,2H,ethoxy CH,,J 7 Hz);9H,. IR: Y 2221 cm-' (GN); 1602, 1589 (skeletal C=N & C=C).…”