A Novel Synthesis of Flavones from 2‐Methoxybenzoic Acids.

Lee, Jae-In; Son, Hwa Soo; Jung, Mi Gung

doi:10.1002/chin.200607144

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Scheme 3: Preparation Of Flavones Via Cyclodehydration Pathway1

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“…Since then, many different acidic and basic conditions have been tried and reported. The use of hydrochloric acid in acetic acid 23 , hydrobromic acid in acetic acid 24 , para-toluene sulfonic acid in xylene 25 and Lewis acids 26 has been reported to yield flavones from 6. Some more important cyclodehydration pathways are discussed in Scheme 2.…”

Section: Scheme 3: Preparation Of Flavones Via Cyclodehydration Pathwaymentioning

confidence: 99%

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2014

IJPSR

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Flavones are an important class of flavonoids having a wide range of biological activities like antioxidant, anti-inflammatory, anti-oestrogenic, antimicrobial, anti-allergic, antioxidant, vascular, antitumor, and cytotoxic activities. First cyclin-dependent kinase inhibitor, flavopiridol, which is a flavone is approved as an orphan drug in Europe for the treatment of relapsed chronic lymphocytic leukemia. So, these structural motifs may show potential activity to wide therapeutic conditions. Thereby synthesis of flavone is an important aspect in medicinal chemistry. This article covers the synthetic strategies available in the literature and their usefulness in terms of yield and reaction condition and the biological activity exerted by the natural and synthetic flavone derivatives and their probable mechanism of action. It is expected that this review may be helpful for medicinal chemist in research regarding flavones with new therapeutic applications.

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Section: Scheme 3: Preparation Of Flavones Via Cyclodehydration Pathwaymentioning

confidence: 99%