A Novel Synergistic Galactomannan-Based Unit Dosage Form for Sustained Release of Acarbose

Abstract

Abstract. In the current study, the potential of a novel combination of a galactomannan with acarbose (100 mg) was evaluated for attaining a desired hypoglycaemic effect over a prolonged period of time. Three major antidiabetic galactomannans viz., fenugreek gum, boswellia gum, and locust bean gum were selected in order to achieve a synergistic effect in the treatment alongwith retardation in drug release. In vitro studies indicated that batches containing various proportions of fenugreek gum (AF40-60) were able to control drug release for a longer duration of approximately 10-12 h. In contrast, the matrices prepared using boswellia and locust bean gum were able to sustain the release for relatively shorter durations. Drug release mainly followed first-order release kinetics owing to the highly soluble nature of the drug. In vivo study depicted a significant reduction (p<0.001) in the postprandial blood glucose and triglyceride levels in the diabetic rats on treatment with formulation AF40. Thus, the developed system provides a better control of the postprandial glycaemic levels and it also obviates the need of conventional multiple dosing of acarbose. Furthermore, it also reduces the occurrence of side effects like diarrhea and loss of appetite.

Development and Characterization of Colon-targeting 5-Fluorouracil Multiparticulate Beads

“…Moreover, Nayak et al also reported that hydrophilic FSM also binds with water to form viscous gel-structure, which barricades the pores on the surface of polymeric matrix [76] . Retardation of drug release from polymer matrix might be the synergistic effect of both viscosity and gel forming properties of FSM, which also corroborated with various earlier findings [48,[77][78][79] .…”

Role of Fenugreek in the prevention of type 2 diabetes mellitus in prediabetes

“…The hypoglycemic effect of Fenugreek seed powder discussed in our study is well supported by few studies [ 9 , 11 , 24 , 25 ] which showed hypoglycemic effect in both type 1 and type 2 diabetes subjects. In vivo study by Kumar RV et al [ 26 ] depicted a significant reduction ( p < 0.001) in the postprandial blood glucose levels in the diabetic rats on treatment with Fenugreek formulation AF40.…”

Spectroscopic and thermodynamic interaction studies of anti-diabetic drug with globular proteins

“…Further to confirm structural changes in the protein with acarbose, the UV-visible spectra were also measured with different concentrations. Figure 2 shows the UV-visible spectra of the different protein-drug complexes where the absorption intensity decreased with increasing concentration with a slight blue shift in the spectrum [1,32 ]. These observed spectra revealed that the interaction between acarbose and proteins changed the structure of proteins.…”

“…Acarbose is a type of noninsulinotropic oral antidiabetic drug molecule, which mainly used to treat type two diabetes [1]. It is mainly used with a proper diet supplemented food and regular exercise to control the blood sugar in humans [2].…”