A novel, swift, and effective green synthesis of morpholino-pyridine analogues in microwave irradiation conditions

A facile microwave‐mediated method of 1,4‐dihydropyridine carboxylates synthesis by multicomponent reaction

“…Irrespective of the substituent groups on the aldehyde that release or take off electrons positioned exceptional yields were obtained. The prepared compounds underwent comprehensive characterization via 1 H NMR, 13 C NMR, and HRMS analyses, establishing all ten compounds as new molecules. For detailed data, refer to additional Data S1.…”

“…The obtained solid was recrystallized using ethanol, yielding the desired pure product. The products were then characterized using 1 H, 13 C NMR, and HRMS techniques (Supplemental file). Ar-H), 5.12 (s, 1H, CH), 4.24 (q, J = 7.1 Hz, 2H, CH 2 ), 3.84 (s, 3H, OCH 3 ), 1.96 (s, 3H, CH 3 ), 1.25 (t, J = 7.1 Hz, 3H, CH 3 ); 13 Experimental conditions: benzaldehydes (1a-j; 1 mmol), ethyl cyanoacetate (2; 1 mmol), acetoacetanilide (3; 1 mmol), ammonium acetate (4; 1 mmol), TEA (0.5 eq.…”

“…b Isolated yields. 7.97 (d, J = 6.9 Hz, 2H, Ar-H), 7.74 (d, J = 7.6 Hz, 2H, Ar-H), 7.45 (q, J = 8.2 Hz, 3H, Ar-H), 7.41-7.34 (m, 1H, Ar-H), 7.15 (t, J = 6.5 Hz, 1H, Ar-H), 5.10 (s, 1H, CH), 4.12 (q, J = 7.1 Hz, 2H, CH 2 ), 2.02 (s, 3H, CH 3 ), 1.17 (t, J = 7.1 Hz, 3H, CH 3 ); 13…”

“…), and solvent (5 mL) at MWI. 3H, Ar-H), 7.96 (d, J = 8.2 Hz, 2H, Ar-H), 7.87 (dd, J = 5.9, 3.3 Hz, 2H, Ar-H), 7.39 (d, J = 8.2 Hz, 2H, Ar-H), 5.24 (s, 1H, CH), 4.29 (q, J = 7.1 Hz, 2H, CH 2 ), 2.24 (s, 3H, CH 3 ), 1.96 (s, 3H, CH 3 ), 1.16 (t, J = 7.6 Hz, 3H, CH 3 );13 C NMR (100 MHz, DMSO-d 6 ) δ 165.0, 162.7, 155.7, 155.4, 151.1, 133.3, 131.8, 129.7, 129.6, 129.5, 127.9, 125.9, 116.6, 101.9, 63.0, 55.2, 29.1, 15.7, 14.7; HRMS of [C 23 H 25 N 3 O 3 + H] + (m/z) 392.0674; Calcd: 392.0681.T A B L E 3 New 1,4-dihydropyridine-carboxylate compounds synthesized employing MWI a .…”

BiCl3-catalyzed green synthesis of 4-hydroxy-2-quinolone analogues under microwave irradiation

“…Many natural and synthetic active products bear a heterocycle within their structures; these molecules are recognized for their vast number of applications in the medical eld, exhibiting various benecial pharmacological activities. [12][13][14][15][16][17][18][19][20] A well-known class of heterocycles, 4-hydroxyquinolin-2-one and its tautomers (Scheme 1), 21 are of great interest in both chemical and medicinal domains. In 2017, the number of described molecules containing a 4-hydroxyquinolin-2-one skeleton reached 14 thousand including nearly 7 thousand compounds that had been subjected to bioactivity studies.…”