A novel, swift, and effective green synthesis of morpholino-pyridine analogues in microwave irradiation conditions

Kumar, Komati Satish; Robert, Alice R.; Kerru, Nagaraju; Maddila, Suresh

doi:10.1016/j.rechem.2022.100692

Cited by 10 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…b Isolated yields. 7.97 (d, J = 6.9 Hz, 2H, Ar-H), 7.74 (d, J = 7.6 Hz, 2H, Ar-H), 7.45 (q, J = 8.2 Hz, 3H, Ar-H), 7.41-7.34 (m, 1H, Ar-H), 7.15 (t, J = 6.5 Hz, 1H, Ar-H), 5.10 (s, 1H, CH), 4.12 (q, J = 7.1 Hz, 2H, CH 2 ), 2.02 (s, 3H, CH 3 ), 1.17 (t, J = 7.1 Hz, 3H, CH 3 ); 13…”

Section: Methodsmentioning

confidence: 99%

“…Compared to conventional heating methods, MWI has numerous advantages, like product purity, precise temperature control, accelerating reactions at high temperatures, faster reaction rates, shorter reaction times, and enhanced purity and yield of final products [11, 12]. A straightforward and safe one‐pot method for creating new organic moieties is offered by MWI [13].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A facile microwave‐mediated method of 1,4‐dihydropyridine carboxylates synthesis by multicomponent reaction

Pachipulusu,

Merugu,

Bhonsle

et al. 2024

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

An innovative green procedure has been devised to prepare derivatives of 1,4‐dihydropyridine (1,4‐DHP). This method works with a catalyst process using ethanol as solvent under microwave irradiation conditions, enabling swift reactions (<30 min) with impressive yields (90%–96%). It contributes to an environmentally friendly and easily executable process by using the energy efficiency method. Within 30 min, this method underscores ecologically conscious practices and offers simple purification, streamlining the process by omitting column chromatography. This method highlights the efficacy and eco‐friendly nature of synthesizing 1,4‐DHPs. This method combines four component reactions, utilizing EtOH as the solvent and triethylamine as the catalyst. Furthermore, the product was characterized by diverse spectroscopic analysis.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A facile microwave‐mediated method of 1,4‐dihydropyridine carboxylates synthesis by multicomponent reaction

Pachipulusu,

Merugu,

Bhonsle

et al. 2024

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

show abstract

“…Our research team has recently focused on investigating a range of environmentally friendly techniques, including ultra-sonication, microwave irradiation, and heterogeneous catalysis [40][41][42][43][44], in order to create novel heterocycles with a variety of biological activities, such as antioxidant, antimicrobial, anticancer, and anti-diabetic agents [45][46][47][48]. Based on these literature reports, Using the literature research mentioned above as a basis, we developed, created, and tested new compounds that combine 1,2,3,4-tetrazole with 2-amino-1,3,4-thiadiazole.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, biological evolution and in silico studies of a novel 1,2,3,4‐tetrazole fused with 1,3,4‐thiadiazole‐2‐amine derivatives

Rajeswari,

Nagaraju,

Yasmintaj

et al. 2024

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

A new series of tetrazole fused with 1,3,4‐thiadiazole‐2‐amine (4a–j) moiety have been synthesized. A thorough characterization of each compound was carried out using mass spectrum data, FT‐IR, 1H, and 13C NMR studies. The antibacterial effectiveness of these prepared substances was assessed in vitro against Gram‐(−) strains of P. aeruginosa and E. coli, as well as Gram‐(+) strains of B. subtilis and S. aureus. Molecules 4f and 4h showed exceptional effectiveness against both types of strains when compared to the reference antibiotic Streptomycin. Moreover the evolution of the molecular docking (in silico) studies also helpful for all the synthesized compounds and reference amoxicillin. The investigation included a look at protein stability, APO‐protein dynamics, and interactions. Using Molecular Dynamics (MD) simulations with Desmond Maestro version 11.3 for this inquiry, a potential lead molecule was found.

show abstract

“…Recently, our research group has focused on exploring a range of environmentally friendly protocols to produce novel heterocycles with a range of biological activities, like antimicrobial, antioxidant, anticancer, and anti‐diabetic agents 55–58 . These methods include heterogeneous catalysis, microwave irradiation, and ultra‐sonication 59–63 . In our quest for the most efficient synthetic technique, we present a successful way to produce hexahydroquinolines employing a multi‐component single‐step reaction consisting of substituted aldehydes, ethyl aceto‐acetate, NH 4 OAc, and cyclohexadione.…”

Section: Introductionmentioning

confidence: 99%

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

Rao,

Maddila,

Anantha

et al. 2024

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

This work aims to explore the catalytic potential of manganese oxide (MnO2) supported on (Fe3O4‐MWCNT) nano‐composite, which is composed of iron oxide and multi‐walled carbon nanotubes. The nano‐composite was synthesized using a simple impregnation technique. The catalyst material was extensively characterized using a variety of possible analytical methods, including X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X‐ray spectroscopy (EDS). Then, utilizing a multi‐component condensation protocol comprising substituted aldehydes, cyclohexadione, ethylacetoacetate, and NH4OAc, the catalytic efficacy of the Fe3O4‐MWCNT@MnO2 nano‐composite was assessed for synthesizing novel hexahydro‐quinoline analogues. The catalyst was found to be effective because of its huge specific surface area, stability, porosity, and distinctive exposed surfaces. The catalyst's surface exhibited an exceptionally active nature, as seen by the notably high turnover frequency. Herein, we present a reusable and effective catalytic method that produces outstanding product yields (93%–97%) under mild reaction conditions, using ethanol as a green solvent. Cost‐effectiveness, environmental safety, and high atom efficiency are achieved using the nano‐composite.

show abstract

A novel, swift, and effective green synthesis of morpholino-pyridine analogues in microwave irradiation conditions

Cited by 10 publications

References 37 publications

A facile microwave‐mediated method of 1,4‐dihydropyridine carboxylates synthesis by multicomponent reaction

A facile microwave‐mediated method of 1,4‐dihydropyridine carboxylates synthesis by multicomponent reaction

Design, synthesis, biological evolution and in silico studies of a novel 1,2,3,4‐tetrazole fused with 1,3,4‐thiadiazole‐2‐amine derivatives

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst

Contact Info

Product

Resources

About

A novel, swift, and effective green synthesis of morpholino-pyridine analogues in microwave irradiation conditions

Cited by 10 publications

References 37 publications

A facile microwave‐mediated method of 1,4‐dihydropyridine carboxylates synthesis by multicomponent reaction

A facile microwave‐mediated method of 1,4‐dihydropyridine carboxylates synthesis by multicomponent reaction

Design, synthesis, biological evolution and in silico studies of a novel 1,2,3,4‐tetrazole fused with 1,3,4‐thiadiazole‐2‐amine derivatives

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe3O4‐MWCNT@MnO2 as a reusable catalyst

Contact Info

Product

Resources

About

A simple, safe, eco‐friendly, and unique synthesis of hexahydro‐quinolines employing Fe₃O₄‐MWCNT@MnO₂ as a reusable catalyst