A novel subtilisin-like serine protease of Batrachochytrium dendrobatidis is induced by thyroid hormone and degrades antimicrobial peptides

Thekkiniath, Jose; Zabet-Moghaddam, Masoud; Francisco, Susan K. San; Francisco, Michael J. San

doi:10.1016/j.funbio.2013.05.002

Cited by 22 publications

(21 citation statements)

References 62 publications

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“…A subtilisin-like serine peptidase was also recently identified in Batrachochytrium dendrobatidis, a chytrid fungus responsible for a global decline in amphibian species. This peptidase was shown to cleave antimicrobial peptides produced by frog skin, and is thus implicated in fungal survival and pathogenesis (43). Furthermore, the kexin gene in C. albicans encodes a subtilisin-type protease that is necessary for virulence because of its role in processing of proproteins (44).…”

Section: Discussionmentioning

confidence: 99%

Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans , the causative agent of white-nose syndrome

O’Donoghue¹,

Knudsen²,

Beekman

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The authors note that in the abstract, lines 22-26, "To our knowledge, these results provide the first molecular insights into the secretome of P. destructans, and identify serine endopeptidases that have the clear potential to facilitate tissue invasion and pathogenesis in the mammalian host" were modified to correct an editorial oversight that occurred during the revision of the manuscript. The sentence has been corrected to read "These results provide molecular insights into the secretome of P. destructans, and identify serine endopeptidases that have the clear potential to facilitate tissue invasion and pathogenesis in the mammalian host." We apologize for this oversight.Also in the significance statement, lines 1-3, "To our knowledge, this work is the first to identify molecular factors produced by the fungus Pseudogymnoascus destructans, the causative agent of white-nose syndrome in bats" has similarly been corrected to read "This work identifies molecular factors produced by the fungus Pseudogymnoascus destructans, the causative agent of white-nose syndrome in bats."The online version has been corrected.www.pnas.org/cgi

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Section: Discussionmentioning

confidence: 99%

Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans , the causative agent of white-nose syndrome

O’Donoghue¹,

Knudsen²,

Beekman

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…Upon metamorphosis, the fungus can spread from the infected mouthparts to the keratinized skin and lead to rapid mortality (Marantelli et al ., 2004; Rachowicz and Vredenburg, 2004). Pathogenicity factors, including proteases that may degrade AMPs, are increased by exposure of Bd to thyroid hormone, which peaks during metamorphosis (Thekkiniath et al ., 2013, 2015). Antimicrobial skin peptides could theoretically play a vital role in protecting some amphibians during this sensitive stage of development.…”

Section: Discussionmentioning

confidence: 99%

Life history linked to immune investment in developing amphibians

et al. 2016

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“…The importance of these expansions in pathogenesis is suggested by several investigations. One study found that a subtilisin-like serine protease was upregulated in response to amphibian host expression of thyroid hormone necessary for amphibian development [135]. The CBM18 gene has the highest copy number of any fungus, ranging from 65-90 copies among sequenced strains, and has been under recent positive selection indicating it may be an important contributor to its pathogenicity [136,137].…”

Section: Gene Family Expansionsmentioning

confidence: 99%

Fungal Genomes and Insights into the Evolution of the Kingdom

Stajich

2017

Microbiol Spectr

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Summary The kingdom Fungi comprises species that inhabit nearly all ecosystems. Fungi exist as both free-living and symbiotic unicellular and multicellular organisms with diverse morphologies [1]. The genomes of fungi encode genes that enable them to thrive in diverse environments, invade plant and animal cells, and participate in nutrient cycling in terrestrial and aquatic ecosystems. The continuously expanding databases of fungal genome sequences have been generated by individual and large-scale efforts such as Génolevures [2], Broad Institute’s Fungal Genome Initiative, and the 1000 fungal genomes project (http://1000.fungalgenomes.org). These efforts have produced a catalog of fungal genes and genomic organization. The genomic datasets can be utilized to better understand how fungi have adapted to their lifestyles and ecological niches. Large datasets of fungal genomic and transcriptomic data have enabled the use of novel methodologies and improved the study of fungal evolution from a molecular sequence perspective [3]. Combined with microscopes, petri dishes, and woodland forays, genome sequencing supports bioinformatics and comparative genomics approaches as important tools in the study of the biology and evolution of fungi.

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A novel subtilisin-like serine protease of Batrachochytrium dendrobatidis is induced by thyroid hormone and degrades antimicrobial peptides

Cited by 22 publications

References 62 publications

Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans , the causative agent of white-nose syndrome

Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans , the causative agent of white-nose syndrome

Life history linked to immune investment in developing amphibians

Fungal Genomes and Insights into the Evolution of the Kingdom

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