A novel styryl diphenylamine derivative reverts the transformed phenotype of human fibrosarcoma HT1080 cells

Neuroblastoma cells provoke Schwann cell proliferation in vitro

“…However, we have previously shown that cultivated NB cells can eliminate amplified MYCN gene copies by micronucleus formation, and that this process results in the formation of F-cells [24]. This fact, together with other properties of F-cells, which also occur in histogenetically distinct tumour cell lines [25][26][27][28], led us to conclude that the F-cells in the NB cell lines we have investigated so far represent a 'revertant' or senescent cell type and not a cell type differentiating along the glial/Schwannian lineage [24]. The results of the in vitro experiments presented in this paper show that NB cells, tumours, and cell lines are able to stimulate SC proliferation.…”