A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression

Abstract

Cancer is a disease of aging, but most studies on cancer are in young but not aged animal models, and cancer clinical trials are rarely performed in older adults. Recognition of the connections between aging and cancer and improvement of treatment for elderly cancer patients has become one of the most critical medical issues with the global increase in the elderly population. Mouse models are essential experimental tools for understanding the molecular mechanisms of complex processes and related gene pathways of biological aging. However, few mouse models can be used to understand the role of aging in cancer development and the underlying mechanisms. One of the hallmarks of aging is chronic inflammation, often called inflammaging. This is our rationale for examining the role of aging-related inflammation in prostate cancer, a major aging malignancy. We have now developed a novel method to generate age-related cancer models in mice to better understand how age impacts cancer initiation and progression in the natural aging process. We discuss its application to elucidate some of the contributing mechanisms.

Mathematical Modeling for the Assessment of Public Policies in the Cancer Health-Care System Implemented for the Colombian Case

“…Although Assumption 7—related to infinite capacity of the health system—is more common in the literature (see, e.g., [ 47 ]), several works have remarked on the need to overcome it [ 2 , 48 , 49 ]. Finally, Assumption 6—related to independence of gender and age—seems to be wrong in light of the findings in [ 50 , 51 ], despite the fact that such a link remains unclear [ 52 ]. However, the availability of new data and models regarding the behavior of such factors will help to overcome these assumptions, possibly leading the proposed structure to become nonlinear.…”

Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging

“…The term inflammaging was first given by Franceschi et al [4] and involves numerous molecular and cellular mechanisms, such as cellular senescence, immunosenescence, mitochondrial, and ubiquitin-proteasome system dysfunction, activation of inflammasome, and DNA damage response [4,5]. Inflammaging can also contribute to the progression of various disease including cardiovascular disease [6], neurodegenerative disorders [7,8], diabetic nephropathy and diabetic retinopathy in diabetes [9][10][11][12], and cancer [13].…”