A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect

Wang, Jing; Kong, Hongwei; Yuan, Zhiyi; Gao, Peng Fei; Dai, Weidong; Hu, Chunxiu; Xu, Guofeng

doi:10.1016/j.jpba.2013.04.035

Cited by 21 publications

(17 citation statements)

References 31 publications

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“…Currently, TCM is gaining increased attention around the world, owing to its good therapeutic effects with minimal or negligible side effects (Wang et al, 2013). Currently, TCM is gaining increased attention around the world, owing to its good therapeutic effects with minimal or negligible side effects (Wang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract

Zhao

Qian

Liu

et al. 2015

Biomedical Chromatography

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In this study, a sensitive and robust ultra-performance liquid chromatography-mass spectrometry method with multiple-reaction monitoring mode was developed, validated, and applied to determine pharmacokinetics of catalpol and acteoside in normal and doxorubicin-induced chronic kidney disease rats after oral administration of Rehmannia glutinosa extract. The lower limits of quantification for catalpol and acteoside in rat plasma were 2.62 and 0.61 ng/mL, with a signal-to-noise ratio of ≥10. Precision and accuracy studies showed that catalpol and acteoside plasma concentrations were within the 10% range in all studies. The extraction recoveries of catalpol and acteoside were both >68.24% and the matrix effects ranged from 96.59 to 101.62%. The method was successfully applied to the pharmacokinetic study of catalpol and acteoside after oral administration of RG extract to normal and model rats, respectively. This study might further support the traditional use of RG to treat kidney diseases clinically.

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Section: Introductionmentioning

confidence: 99%

Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract

Zhao

Qian

Liu

et al. 2015

Biomedical Chromatography

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“…[11] Growing evidence shows that metabolomics may provide some novel strategies to discover biomarkers and screen bioactive substances. [20] The present study exploited the new developments in HPLC-based metabolomics to evaluate the antioxidant capacity. Our optimized analytical method provided the metabolic profiles to evaluate the antioxidant capacity.…”

Section: Discussionmentioning

confidence: 99%

Intracellular Metabolomic Approach for Evaluating Antioxidant Capacity and Its Application

Zhao

Wei

2015

Journal of Liquid Chromatography & Related Technologies

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Metabolomics is frequently used in the analysis of the dynamic changes within small molecules in response to the disturbance in an organism. It has been extensively used in various fields involving human diseases. To better evaluate the antioxidant capacity, cells subjected to oxidative stress were cultured, and the intracellular metabolites were prepared using HSDE (high-speed shear dispersing emulsifier)-assisted extraction. The metabolites were then analyzed under optimized chromatographic conditions. Partial least squares discriminate analysis was used to analyze the data. A new intracellular metabolomic approach was established, and four potential metabolic biomarkers for repairing oxidative stress were found. The antioxidant activities of Cynomorium songaricum was successfully evaluated using the intracellular metabolomic approach, indicating the feasibility of the proposed approach as an effective tool for evaluating the antioxidant capacity.

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“…Effluent collected in the first 5 min under 2% B and labeled as fraction 0 was used to flush the strong polar compounds, such as monosaccharides, polysaccharides and amino acids, to reduce interference in the MS and NMR signals. The remaining 20 fractions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were collected from the p-HPLC every 3 min. Data were processed by ChemStation B.04.03 software.…”

Section: P-hplc Conditionsmentioning

confidence: 99%

“…Nowadays, TCM is attracting increasing attention worldwide due to its distinguished efficiency and minimal or negligible toxicity [1][2][3]. However, the disadvantages, including poor quality control, ambiguous pharmacodynamics and indefinable therapeutic mechanisms, limit the worldwide spread of TCM [4].…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent targeted knockout methodology combined with deep structure elucidation strategies for Chinese licorice chemical profiling

Jiang

Wang

Zhu

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect

Cited by 21 publications

References 31 publications

Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract

Comparative pharmacokinetics of catalpol and acteoside in normal and chronic kidney disease rats after oral administration of Rehmannia glutinosa extract

Intracellular Metabolomic Approach for Evaluating Antioxidant Capacity and Its Application

Dose-dependent targeted knockout methodology combined with deep structure elucidation strategies for Chinese licorice chemical profiling

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