A Novel Strategy for Treating Inflammatory Bowel Disease by Targeting Delivery of Methotrexate through Glucan Particles

Sun, Yu; Duan, Bo; Chen, Huanhuan; Xu, Xiaojuan

doi:10.1002/adhm.201901805

Cited by 38 publications

(29 citation statements)

References 72 publications

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“…This work aims to combine aPDT and silver into hybrid nanocarrier to combat bacteria. In addition, the methotrexate (MTX) is also included in the nano-carrier to treat the inflammatory reaction associated with bacterial infection (Lebugle et al, 2002;Alam et al, 2017;Yang et al, 2017;Duan and Li, 2018;Trujillo-Nolasco et al, 2019;Sun et al, 2020). To address the aforementioned issues of bare silver nanoparticles, different nano-carriers have been constructed, such as metalorganic frameworks (MOFs) (Ximing et al, 2017;Zhang et al, 2019Zhang et al, , 2020, hybrid metallic nanoparticles (Mahmoudi and Serpooshan, 2012;Durmus and Webster, 2013;Mei et al, 2013;Shah et al, 2013;Agnihotri et al, 2015;Lim et al, 2015;Kyaw et al, 2017;Kim et al, 2018;Liu et al, 2018;Gasmalla et al, 2019;He et al, 2020;Tong et al, 2020) and mesoporous nanoparticles (Liu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

et al. 2021

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The over-use of antibiotics has promoted multidrug resistance and decreased the efficacy of antibiotic therapy. Thus, it is still in great need to develop efficient treatment strategies to combat the bacteria infection. The antimicrobial photodynamic therapy (aPDT) and silver nanoparticles have been emerged as effective antibacterial methods. However, the silver therapy may induce serious damages to human cells at high concentrations and, the bare silver nanoparticles may rapidly aggregate, which would reduce the antibacterial efficacy. The encapsulation of sliver by nano-carrier is a promising way to avoid its aggregation and facilitates the co-delivery of drugs for combination therapy, which does not require high concentration of sliver to exert antibacterial efficacy. This work constructed a self-assembled supermolecular nano-carrier consisting of the photosensitizers (PSs), the anti-inflammatory agent and silver. The synthesized supermolecular nano-carrier produced reactive oxygen species (ROS) under the exposure of 620-nm laser. It exhibited satisfying biocompatibility in L02 cells. And, this nano-carrier showed excellent antibacterial efficacy in Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as indicated by bacterial growth and colony formation. Its antibacterial performance is further validated by the bacteria morphology through the scanning electron microscope (SEM), showing severely damaged structures of bacteria. To summary, the supermolecular nano-carrier TCPP-MTX-Ag-NP combining the therapeutic effects of ROS and silver may serve as a novel strategy of treatment for bacterial infection.

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Section: Introductionmentioning

confidence: 99%

The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

et al. 2021

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“… 84 Sun et al synthesized yeast cell wall-coated immunosuppressive agent methotrexate (MTX)-loaded nanoparticles (YGPs/MTX) for targeted IBD therapy. 85 Taken orally, the drug-loaded system preferentially internalized into macrophages, which promoted the uptake of MTX by macrophages, leading to the suppression of NO, TNF-α, IL-6, and IL-1β secretion. With the active targeting effects, the YGPs/MTX showed excellent anti-inflammatory effects in vivo.…”

Section: Passively and Actively Targeted Drug Deliverymentioning

confidence: 99%

Recent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease

Wang¹,

Yu²,

Yang³

2021

JIR

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The effective colon drug delivery remains to be an international frontier research in inflammatory bowel disease (IBD) therapy. The exploration and research of nanocarrier-based nanomedicine with great potential brings new opportunities for IBD therapy and diagnoses. Functional nanocarriers with varying morphology and characteristics can not only effectively avoid the destruction of the complex gastrointestinal (GI) tract microenvironment but also endow drugs with target therapy and improved bioavailability, thus elevating therapeutic efﬁcacy. In this review, we illustrated several challenges in IBD therapy, then emphasis on some latest research progress of nanoparticles based therapy of oral administration, rectal administration and parenteral administration, as well as IBD diagnoses. Finally, we described the future perspective of nanocarriers in the treatment and diagnoses of IBD.

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“…Accordingly, yeasts have been adopted to deliver many pharmaceutical agents, including small-and large-molecule drugs (45)(46)(47), genetic materials (48), and vaccines (49). For example, an oral delivery of yeast glucan particles carrying methotrexate, an anti-inflammatory drug, was shown to be effective in treating mice with inflammatory bowel disease (50). The study reported that drug-containing yeast glucan particles were internalized through macrophages, with subsequent down-regulation of macrophage-induced pro-inflammatory cytokines.…”

Section: Yeasts As Oral Vaccine and Gene Delivery Agents Yeast Characteristicsmentioning

confidence: 99%

Yeasts in nanotechnology-enabled oral vaccine and gene delivery

Иванова

2021

Bioengineered

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Oral vaccine and gene delivery systems must be engineered to withstand several different physiological environments, such as those present in the oral cavity, stomach, and jejunum, each of which exhibits varying pH levels and enzyme distributions. Additionally, these systems must be designed to ensure appropriate gastrointestinal absorption and tissue/cellular targeting properties. Although a plethora of nanomaterials are employed in the construction of these delivery devices, yeasts display unique characteristics, such a rigid cell wall and a resistance to harsh environments, that make them a prime vehicle for oral delivery of active pharmaceutical agents, vaccines, and genetic material. The ability of yeast cells to adhere to other cells or substrates is a crucial property that allows for more efficient gastrointestinal passage and subsequent systemic circulation, which has enabled substantial advancements in therapeutic efficacy in the pharmaceutical arena. Among several discoveries, the feasibility of yeast for vaccine and gene delivery is supported by findings from recent studies that yeasts have the ability to independently activate or deactivate separate but co-functioning portions of the immune system to synergistically ameliorate treatment effects. The purpose of this review is to present current information on the uses of yeast in the development of oral vaccines and gene delivery systems with an emphasis on yeast-related mechanisms of immune system activation, along with potential clinical implications in terms of disease targets and approaches to formulations. ResultsThe oral route for delivery of vaccines and gene therapies offers a number of advantages, including ease of administration, manufacturing efficiency, and cost. However, before widespread adoption of this therapeutic modality can occur, factors such as adequate local and systemic availability of the therapeutic agent and accurate targeting of tissues and cells, are just some of the challenges that must be addressed. Yeasts-based delivery vehicles are excellent candidates for oral vaccine and oral gene therapies as many species possess cellular characteristics resulting in enhanced resistance to the harsh gastrointestinal (GI) environment and facilitated passage across the mucosal barrier. Yeast capsules can stimulate and modulate host immune responses, which is beneficial for vaccine efficacy. In addition, recombinant modification of yeasts to express cell penetrating proteins and injection mechanisms along with efficient cell adhering capabilities can potentially improve transfection rates of genetic material. In this literature review, we present evidence supporting the beneficial role yeast-based delivery systems can play in increasing the efficacy of oral administration of vaccines and gene therapies.

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A Novel Strategy for Treating Inflammatory Bowel Disease by Targeting Delivery of Methotrexate through Glucan Particles

Cited by 38 publications

References 72 publications

The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

Recent Progress in the Diagnosis and Precise Nanocarrier-Mediated Therapy of Inflammatory Bowel Disease

Yeasts in nanotechnology-enabled oral vaccine and gene delivery

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