A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples

Farnoudian-Habibi, Amir; Massoumi, Bakhshali; Jaymand, Mehdi

doi:10.1016/j.saa.2016.06.013

Cited by 25 publications

(6 citation statements)

References 41 publications

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“…It is an unquestionable fact that the adsorbent amount significantly affects the adsorption process . The effect of adsorbent amounts on the adsorption processes were investigated at 0.01, 0.05, and 0.1 g of adsorbent between 0 and 90 min at initial dyes concentrations of 10 ppm, ionic strength of 0.01 mol L −1 sodium chloride and 0.003 mol L −1 sodium carbonate, and pH 2.…”

Section: Resultsmentioning

confidence: 99%

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Cellulose/polyaniline derivatives nanocomposites: Synthesis and their performance in removal of anionic dyes from simulated industrial effluents

Abbasian

Niroomand

Jaymand

2017

J of Applied Polymer Sci

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A series of cellulose/polyaniline derivatives [polyaniline (PANI), poly(N-methylaniline) (PNMANI), and poly(N-ethylaniline) (PNEANI)] nanocomposites were synthesized by in situ chemical oxidation polymerization method and successfully applied for removal of acid red 4 and direct red 23 dyes from simulated industrial effluents. The synthesized nanocomposites were analyzed using Fourier transform infrared and ultraviolet-visible spectroscopies, thermogravimetric analysis and scanning electron microscope. The effect of some parameters including pH, adsorbent amount, and initial dyes concentrations on adsorption processes were evaluated. The maximum adsorption capacities (Q m ) for the synthesized nanocomposites were calculated, and among them the Cell/PANI sample showed the highest Q m for both AR4 (117 mg g -1 ) and DR23 (56 mg g -1 ) dyes. The regeneration and reusability tests exhibited that the synthesized nanocomposites had the relatively good reusability after five repetitions of the adsorption-desorption cycles. According to results, we envision that these nanocomposites, especially Cell/PANI, find application for removal of anionic dyes from industrial effluents mainly due to their low production costs, high adsorption effectiveness, and relatively good reusability.

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Section: Resultsmentioning

confidence: 99%

“…It is well established that the adsorption processes are affected greatly by the solution pH . In the case of PANIs‐based adsorbents (e.g., Cell/PANIs nanocomposites), the nitrogen atoms of PANIs are protonated (NH + ) in acidic solution.…”

Section: Resultsmentioning

confidence: 99%

Cellulose/polyaniline derivatives nanocomposites: Synthesis and their performance in removal of anionic dyes from simulated industrial effluents

Abbasian

Niroomand

Jaymand

2017

J of Applied Polymer Sci

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“…It is an unquestionable fact that the MNPs have attracted great deal of research efforts over the past decade in technological as well as biomedical applications. These NPs have been extensively employed as magnetic storage media, ferrofluids, in analytical and bioanalytical fields, heterogeneous catalysis as well as biomedical fields including magnetic resonance imaging tools, medical diagnoses, and drug and gene delivery …”

Section: Introductionmentioning

confidence: 99%

“…14,15 It is an unquestionable fact that the MNPs have attracted great deal of research efforts over the past decade in technological as well as biomedical applications. These NPs have been extensively employed as magnetic storage media, 16 ferrofluids, 17 in analytical and bioanalytical fields, 18,19 heterogeneous catalysis as well as biomedical fields including magnetic resonance imaging tools, 20 medical diagnoses, 21 and drug and gene delivery. 22,23 In general, the surface of MNPs is modified using small molecules or these NPs are usually encapsulated with macromolecules and surfactants to avoid particle aggregation and improve their chemical stabilities (e.g., prevent the oxidation of the magnetic core).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Mozaffari

Hatamzadeh

Massoumi

et al. 2018

J of Applied Polymer Sci

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A novel stimuli‐responsive magnetite nanohydrogel (MNHG), namely [poly(ethylene glycol)‐block‐poly(N‐isopropylacrylamide‐co‐maleic anhydride)2]‐graft‐poly(ethylene glycol)/Fe3O4 [PEG‐b‐(PNIPAAm‐co‐PMA)2]‐g‐PEG/Fe3O4, was successfully developed. For this purpose, NIPAAm and MA monomers were block copolymerized onto PEG‐based macroinitiator through atom transfer radical polymerization technique to produce PEG‐b‐(PNIPAAm‐co‐PMA)2. The synthesized Y‐shaped terpolymer was crosslinked through the esterification of maleic anhydride units using PEG chains to afford a hydrogel. Afterward, magnetite nanoparticles were incorporated into the synthesized hydrogel through the physical interactions. The chemical structures of all synthesized samples were characterized using Fourier transform infrared and proton nuclear magnetic resonance spectroscopies. Morphology, thermal stability, size, and magnetic properties of the synthesized MNHG were investigated. In addition, the doxorubicin hydrochloride loading and encapsulation efficiencies as well as stimuli‐responsive drug release ability of the synthesized MNHG were also evaluated. The drug‐loaded MNHG at physiological condition exhibited negligible drug release values. In contrast, at acidic (pH 5.3) condition and a little bit higher temperature (41 °C) the developed MNHG showed higher drug release values, which qualified it for cancer chemotherapy due to especial physiology of cancerous tissue in comparison with the surrounding normal tissue. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46657.

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“…Amitriptyline is one of the mostly widely used tricyclic antidepressants for treatment of depression, anxiety, and a variety of chronic pain syndromes (Li et al, 2013; Ivetić et al, 2016). It is mainly metabolized by demethylation, forming nortriptyline (Farnoudian‐Habibi et al, 2016). Both amitriptyline and its active metabolite, nortriptyline, cannot be completely removed by wastewater treatment plants, and thus they have been detected extensively in surface waters (Kasprzyk‐Hordern et al, 2008; Baker and Kasprzyk‐Hordern, 2011; Baker et al, 2012; Lajeunesse et al, 2012; Aminot et al, 2015; Wu et al, 2015).…”

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confidence: 99%

Photosensitized Degradation of Amitriptyline and Its Active Metabolite Nortriptyline in Aqueous Fulvic Acid Solution

et al. 2017

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Amitriptyline is a frequently prescribed tricyclic antidepressant. Although amitriptyline and its active metabolite, nortriptyline, have been widely detected in natural waters, their environmental fate due to photodegradation is poorly understood. Here we describe a study conducted to investigate the photodegradation of amitriptyline and its active metabolite under simulated sunlight. Neither amitriptyline nor nortriptyline underwent direct photodegradation, but rapid photosensitized degradation did occur in fulvic acid (FA) solutions. The photodegradation of amitriptyline and nortriptyline followed pseudo-first-order kinetics with rate constants 0.24 and 0.16 h, respectively, at pH 8.0 in air-saturated FA solutions. The photodegradation of the substrates increased markedly with pH. The deprotonation of amitriptyline and nortriptyline facilitated the availability of nonbonding electrons on nitrogen (N-electrons). The excited triplet state of FA (FA*) was verified as the main reactive species responsible for the photosensitized degradation. An electron transfer mechanism for the interaction between substrates and FA* was proposed on the basis of a series of quenching experiments, kinetic model and photoproducts determination. Demethylation at the α-carbon of amine and hydroxylation were two primary photochemical processes initiated by the electron transfer reaction in the air-saturated FA solution; these were followed by generation of demethyl amine and mono-hydroxylation isomers. Our results suggest that indirect photodegradation is an important elimination process for amitriptyline and its active metabolite in natural waters.

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A novel strategy for spectrophotometric simultaneous determination of amitriptyline and nortriptyline based on derivation with a quinonoid compound in serum samples

Cited by 25 publications

References 41 publications

Cellulose/polyaniline derivatives nanocomposites: Synthesis and their performance in removal of anionic dyes from simulated industrial effluents

Cellulose/polyaniline derivatives nanocomposites: Synthesis and their performance in removal of anionic dyes from simulated industrial effluents

Synthesis and characterization of a novel stimuli‐responsive magnetite nanohydrogel based on poly(ethylene glycol) and poly(N‐isopropylacrylamide) as drug carrier

Photosensitized Degradation of Amitriptyline and Its Active Metabolite Nortriptyline in Aqueous Fulvic Acid Solution

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