A novel statistical framework for meta-analysis of total mediation effect with high dimensional omics mediators in large-scale genomic consortia
Zhichao Xu,
Peng Wei
Abstract:Meta-analysis is used to aggregate the effects of interest across multiple studies, while its methodology is largely underexplored in mediation analysis, particularly in estimating the total mediation effect of high-dimensional omics mediators. Large-scale genomic consortia, such as the Trans-Omics for Precision Medicine (TOPMed) program, comprise multiple cohorts with diverse technologies to elucidate the genetic architecture and biological mechanisms underlying complex human traits and diseases. Leveraging t… Show more
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