Nanofluid is a solid-fluid mixture. By using one solid nanoparticle or one fluid, mono-nanofluid (MN) forms, and by using two solid nanoparticles (NPs) or two fluids, hybrid-nanofluid (HN) forms. For this study, for MN, copper oxide (CuO) and for HN, two solids, which are CuO and multi-walled carbon nanotube (MWCNT) were dispersed in base fluid which is water. After nanofluid preparation, thermal conductivity was measured, and the achievements were numerically modeled. After that, XRD-EDX were performed for the phase-structural analysis. Then, FESEM was examined for NPs-microstructural study. Thermal conductivity (TC) of MN and HN were investigated at 0.2 % to 1.0 % volume fractions (Vf) in 25 °C to 50 °C temperature (T) ranges. Thermal conductivity enhancements of 19.16 % and 37.05 % were seen at the utmost Vf and T for mono-nanofluid and hybrid-nanofluid, respectively. New correlations have been presented with R 2 = 0.9, and also Artificial Neural Network (ANN) has been done with R 2 = 0.999. For the presented correlation, 0.86 %, and 0.51 % deviations, and for the trained model, 0.41 % and 0.51 % deviations were estimated for mono-nanofluid and hybrid-nanofluid, respectively. As a final result, by adding MWCNT to CuO-H 2 O mixture, thermal conductivity is raised by 17.89 %, and the hybrid-nanofluid has acceptable heat-transfer capability.