A Novel Standard for Systematic Reporting of Neuroblastoma Surgery: The International Neuroblastoma Surgical Report Form (INSRF)

Matthyssens, Lucas; Nuchtern, Jed G.; Ven, Cornelis P. van de; Gabra, Hany; Björnland, Kristin; Irtan, Sabine; Stenman, Jakob; Pio, Luca; Cross, Kate; Avanzini, Stefano; Inserra, Alessandro; Chacon, Javier Gomez; Dall’Igna, Patrizia; Schweinitz, Dietrich von; Holmes, Keith; Fuchs, Jörg; Squire, Roly; Valteau‐Couanet, Dominique; Park, Julie R.; Eggert, Angelika; Losty, Paul D.; Quaglia, Michael P. La; Sarnacki, Sabine

doi:10.1097/sla.0000000000003947

Cited by 20 publications

(25 citation statements)

References 38 publications

(105 reference statements)

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“…Structured recording of any intra- and postoperative complications (especially within the first 30 days after surgery) is highly recommended. This is also an important part of the ‘International Neuroblastoma Surgical Report Form’ (INSRF), a multi-committee standard reporting system for neuroblastoma surgery [ 71 ].…”

Section: Complicationsmentioning

confidence: 99%

“…Recording of surgical details should adhere to the framework of the INSRF, a multi-committee standard reporting system for neuroblastoma surgery [ 71 ].…”

Section: Tips and Pitfallsmentioning

confidence: 99%

“…(INSRF)’ [ 22 ], a multi-committee standardised reporting system for the surgery of neuroblastic tumours is encouraged because of the analogy in localisation (adrenal, retroperitoneal, pelvic, mediastinal) between PPGL and neuroblastic tumours.…”

Section: Postoperative Outcome and Follow-upmentioning

confidence: 99%

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International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

Abib¹,

Chui²,

Cox³

et al. 2022

ecancer

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Most children with tumors will require one or more surgical interventions as part of the care and treatment, including making a diagnosis, obtaining adequate venous access, performing a surgical resection for solid tumors (with staging and reconstruction), performing procedures for cancer prevention and its late effects, and managing complications of treatment; all with the goal of improving survival and quality of life. It is important for surgeons to adhere to sound pediatric surgical oncology principles, as they are closely associated with improved local control and survival. Unfortunately, there is a significant disparity in survival rates in low and middle income countries, when compared to those from high income countries.The International Society of Paediatric Surgical Oncology (IPSO) is the leading organization that deals with pediatric surgical oncology worldwide. This organization allows experts in the field from around the globe to gather and address the surgical needs of children with cancer. IPSO has been invited to contribute surgical guidance as part of the World Health Organization Initiative for Childhood Cancer. One of our goals is to provide surgical guidance for different scenarios, including those experienced in High-(HICs) and Low-and Middle-Income Countries (LMICs). With this in mind, the following guidelines have been developed by authors from both HICs and LMICs. These have been further validated by experts with the aim of providing evidence-based information for surgeons who care for children with cancer.We hope that this initiative will benefit children worldwide in the best way possible.

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Section: Complicationsmentioning

confidence: 99%

“…Recording of surgical details should adhere to the framework of the INSRF, a multi-committee standard reporting system for neuroblastoma surgery [ 71 ].…”

Section: Tips and Pitfallsmentioning

confidence: 99%

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International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

Abib¹,

Chui²,

Cox³

et al. 2022

ecancer

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show abstract

“…This suggests that, in planning neuroblastoma resection, radiologists and surgeons could work together to highlight specific IDRF that might increase the risk of specific complications and plan steps to mitigate this risk. Radiological reporting of neuroblastomas could highlight specific IDRF, perhaps using a standardized neuroblastoma reporting format along the lines of the recently published International Neuroblastoma Surgical Reporting Form [22]. It will be helpful for less experienced pediatric surgical oncologists to be wary of specific complications associated with certain IDRF and take care to avoid these.…”

Section: Discussionmentioning

confidence: 99%

Vascular Encasement Image Defined Risk Factors Predict Surgical Complications in Neuroblastoma

Stokes

Bannon

Leung

et al. 2022

Preprint

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BackgroundSpecific Image Defined Risk Factors (IDRF) may be of more relevance to the pediatric surgical oncologist than simply the presence of any IDRF. The aim of this study was to correlate IDRF with surgical complications with reference to vascular encasement IDRF and the grade of complication.MethodsWe searched the New Zealand Children’s Cancer Registry for all cases of neuroblastoma treated at a single pediatric oncology center between January 2007 – February 2021 and reviewed the pre-treatment axial imaging for IDRF status. Surgical complications were scored by Clavien-Dindo grade and correlated with the number of IDRF and with the subset of vascular encasement IDRF.ResultsOf 101 patients, 77 were IDRF positive. In total, 74 underwent surgical resection and 32 (43.2%) had a surgical complication. Complications were related to the number of IDRF (OR 1.33, 95% CI 1.05 – 1.73, p = 0.02) and the subgroup of vascular encasement IDRF (OR 1.78, 95% CI 1.12 – 3.04, p = 0.01) but were not significantly correlated with the subgroup of non-vascular encasement IDRF. We report three cases of chyle leak associated with tumor encasing the origin of the celiac axis and/or the superior mesenteric artery.ConclusionsThe vascular encasement IDRF subgroup is potentially a more useful prognostic indicator of surgical complications than non-vascular IDRF. More studies are needed to correlate specific IDRF with specific surgical complications to aid operative decision making.Level of evidenceLevel IIIHighlightsImage Defined Risk Factors (IDRF) in neuroblastoma correlate with survival, completeness of resection, and surgical complications.Complications correlate specifically with the subset of vascular encasement IDRF. Chylous ascites was a specific complication associated with encasement of the celiac and superior mesenteric vessels.

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“…[23][24][25] Furthermore, a reporting standard has been developed for NB surgical procedures. 26 Autologous stem cell TA B L E 3 The view on the management of neuroblastoma according to World Bank Lending and Income Group (p = .006) being a significant burden on resources. The burden can be decreased with innovative adaptations to treatment.…”

Section: Discussionmentioning

confidence: 99%

Neuroblastoma: The basis for cure in limited‐resource settings

Heerden

Kruger

Esterhuizen

et al. 2021

Pediatric Blood & Cancer

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Background: Neuroblastoma (NB) contributes the most to the mortality of childhood malignancies worldwide. The disease spectrum is heterogenous and the management complex and costly, especially in advanced disease or disease with adverse biology. In low-and middle-income countries (LMICs) the majority of NB presents in advanced stages. Therefore, with limited resources and poor prognosis the treatment of NB is often not a priority. The aim of the study was to evaluate the research activities and perceptions of the management of NB that determine the research and treatment approaches in LMICs. Methods: Data were sourced from https://www.clinicaltrials.gov/ identifying NB trials open to LMIC. Abstracts on NB research presented at the International Society for Paediatric Oncology (SIOP) Congresses between 2014 and 2020 were evaluated according to income status. An online survey evaluating medical views on NB in LMICs and the effect on the management was conducted. Descriptive analysis was done. Where appropriate categorical association between covariates was assessed using the Pearson chi-square (χ 2 ) test or Fishers exact test. Results: There were 15/562 (2.7%) trials open to LMIC. Only six of 138 (4.3%) LMIC participated in NB trials. Of the 688 abstracts presented between 2014 and 2020 at the SIOP International Congress on NB as primary subject, 297 (42.7%) were from LMICs. Only two were from low-income countries (LICs). Sixty-one countries responded to the NB survey. Positive views towards NB management were present when treatment was based on a national protocol, the availability of trimodal or advanced treatment options were present, and when a balance of metastatic or local disease were treated. Conclusion: Management of NB in LMICs should include increased advocacy and research as well as implementation of national management strategies.

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A Novel Standard for Systematic Reporting of Neuroblastoma Surgery: The International Neuroblastoma Surgical Report Form (INSRF)

Cited by 20 publications

References 38 publications

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

International Society of Paediatric Surgical Oncology (IPSO) Surgical Practice Guidelines

Vascular Encasement Image Defined Risk Factors Predict Surgical Complications in Neuroblastoma

Neuroblastoma: The basis for cure in limited‐resource settings

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